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Peptiva Probiotics + Sleep Support Review: Pros, Cons, and More

Written by Markita Lewis, MS, RD

Published on March 29, 2021

Our Expert Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:5.0
  • Ingredient Safety:4.0
  • Value for the Price:4.0
  • Brand Transparency:3.0

Peptiva Probiotics + Sleep Support combines effective probiotic strains and a blend of ingredients known to support sleep quality. This is a convenient product that may be beneficial for achieving wellness while you sleep.

Peptiva Probiotics + Sleep Support Review: Pros, Cons, and More


  • Ingredients are supported by research for effectiveness
  • Simple to take; can be taken with or without food
  • Free of major allergens; vegan and vegetarian-safe


  • Somewhat pricier compared to other nighttime probiotics
  • Requires several months of taking to experience all benefits from this supplement
  • No third-party testing label


Peptiva Probiotics + Sleep Support is a supplement designed to support digestive health while promoting relaxation and sleep in adults.

Benefits for sleep and relaxation can be felt after 30 minutes, but digestive benefits are likely to be seen after 8 to 12 weeks of consistent use.

Dr. David Katz, and preventative medicine specialist and former director and co-founder of the Yale Prevention Research Center, was involved with the formulation and selection of the probiotic strains used in Peptiva Probiotics products.

Evaluation of Ingredients

Lactobacillus acidophilus (ATCC SD6865 and SD6866)

L. acidophilus is the most commonly used probiotic to promote gut health.

This bacteria species improves gastrointestinal function, reduces inflammation in the gut, and may improve the balance of gut bacteria.

One clinical trial found that taking L. acidophilus twice daily improved symptoms of bloating in patients with digestive illnesses after 4 weeks.

Bifidobacterium bifidum

B. bifidum species is one of the first types of bacteria to be found in the infant gastrointestinal tract and is known to strengthen the gut.

In a randomized trial, patients with IBS symptoms either took a placebo or a B. bacterium strain for 4 weeks, once per day.

At the end of the trial, patients had a significant improvement in pain, bloating, digestive problems, and bowel control compared to a control.

Bifidobacterium animalis subsp. lactis (ATCC SD6870)

B. animalis is a species recognized to improve gut microbiota and overall health by reducing gut dysbiosis or an imbalance of bacteria in the gut.

One randomized trial found that B. lactis supplementation for 6 weeks significantly improved abdominal pain, bloating, bowel habits, and quality of life in adults with IBS compared to a placebo.

Lactobacillus rhamnosus (IMC501)

L. rhamnosus is able to protect the digestive cells and reduce inflammation.

Research supports strains of L. rhamnosus to be effective in improving diarrhea in a number of conditions, including cancer treatment-related diarrhea and diarrhea resulting from antibiotics and C. diff colitis.

Lactobacillus paracasei (IMC502)

L. paracasei is a bacteria species that is found in the human body but also within milk and other dairy products.

In a trial, individuals with different types of IBS were given L. paracasei, B. longum, or a placebo for eight weeks.

Individuals who received a probiotic had improvements in GI symptoms. Those who received L. paracasei had improvements in bowel movement frequency and improvement of quality of life.

Valerian Root Extract

Valerian is a flowering plant native to Europe and Asia, whose roots are often used as an herbal sleep aid.

While some of the research on benefits is inconsistent, a review and meta-analysis of 60 studies found that valerian root can be effective for improving sleep quality and reducing anxiety.

Gamma-Aminobutyric Acid (from PharmaGABA)

Gamma-aminobutyric acid (GABA) is an amino acid and neurotransmitter.

GABA decreases waking and increases slow-wave sleep (the stage associated with sleep quality and sleep restoration).

Intake of GABA alone and with Apocynum venetum leaf extract was found to decrease time to fall asleep and increase slow-wave sleep.


Melatonin is a hormone that is made by the pineal gland and helps regulate the circadian rhythms of the brain.

This hormone is found in studies to be helpful in sleep disorders, including insomnia, sleep-related breathing disorders, and other conditions.

It can help improve the onset, duration, and quality of sleep among individuals.

Verdict on Claimed Benefits

Below is our summary of the available evidence for the claimed benefits of Peptiva Probiotics + Sleep Support based on the available research:

  • Supports digestive healthGold Star Evidence
  • Relieves bloating, indigestion and constipationGold Star Evidence
  • Supports relaxation and sleepGold Star Evidence

Side Effects, Safety, and Dosage

The dosage of Peptiva Probiotics + Sleep Support is one capsule daily, taken 30 to 60 minutes before bedtime.

This supplement can be taken with or without food. For improved digestive comfort, it is recommended to take with a small snack.

Peptiva Probiotics + Sleep Support is made for adults.

While there are no side effects noted from this supplement, some individuals may experience vivid dreams due to the melatonin included.

As with any supplement, it is recommended to consult a healthcare practitioner before initiating a new supplement.

Peptiva notes that individuals taking antibiotics or corticosteroids may have interactions or experience fewer benefits of the probiotic.

Pregnant or breastfeeding women should consult with their physician before taking this supplement, especially due to the limited research on the safety of certain ingredients during pregnancy.

Peptiva Probiotics + Sleep Support does not contain any known major allergens. This supplement is vegan.

The company notes that its labs are GMP-certified; no additional third-party testing was noted on the Peptiva website.

Cost and Where to Buy

Peptiva products are currently only available through the company’s website or GNC, their exclusive retail partner.

A one-month supply of Peptiva Probiotics + Sleep Support costs $59.99 per bottle.

If you don’t want to commit to purchasing a full bottle of this supplement, Peptiva offers a 15-day sample trial on its website.

When signing up for the trial, you sign up for a subscription for the product – if you don’t like Peptiva Probiotics + Sleep Support, you can call their customer service line to avoid future billing.

A 30-day money-back guarantee is available for Peptiva products if you’re not completely satisfied with your purchase.

Given that Peptiva Probiotics + Sleep Support combines a sleep supplement and probiotic, its cost appears reasonable.

How It Compares

There aren’t too many nighttime probiotics on the market. Out of the ones that I saw, Peptiva Probiotic + Sleep Support is more expensive than its competitors.

Despite its cost, it does have some advantages compared to its competitors.

Some nighttime probiotics either only contained one beneficial strain of probiotics, did not contain melatonin, or overall had a lower concentration of bacteria colonies for its probiotic.

The Bottom Line

Overall, Peptiva Probiotic + Sleep Support appears to be a well-formulated nighttime probiotic.

All of its ingredients have randomized trials, the gold standard of research, to support its claims.

It is also simple to take, with minimal risks for side effects or interactions for most people.

This supplement appears to be a good addition to a lifestyle to support gut and sleep health.

A Word from Our RD

I believe it is important for people to take care of their gut and sleep quality to improve their overall health.

Probiotic supplements can help maintain a healthy gut. Still, it is important to note that oral probiotics have to be taken consistently to have an effect, and the benefits may disappear once you stop taking them.

Having probiotic-containing foods like yogurt, fermented cabbage, and kefir in the diet can consistently support gut health.

To support healthy bacteria growth, various fruits, vegetables, and whole grains contain helpful prebiotics to feed healthy bacteria.

As far as sleep health goes, I personally use valerian root occasionally in tea to support my sleep. However, this is not a substitute for other sleep hygiene habits.

To optimize your health, plan your day to get 7–9 hours of sleep at night.

Some important sleep habits include creating a quiet and comfortable environment, reducing exposure to blue light or bright screens before bed, and doing relaxing activities in the hour before sleep.

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