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Seed Probiotics Review: Pros, Cons, Effectiveness, and More

Written by Markita Lewis, MS, RD

Reviewed by Anthony Dugarte, MD 

Last Updated on May 18, 2021

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:4.0
  • Ingredient Safety:4.0
  • Value for the Price:4.0
  • Brand Transparency:4.0

Seed’s DS-01 Daily Synbiotic strains were carefully chosen by a well-qualified scientific advisory board and by a brand that centers the science in their products. This product may be a little pricey, but it is worth the investment.

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Seed Probiotics Review: Pros, Cons, Effectiveness, and More
Photo credit: iStock.com/Drazen


  • Most ingredients are well supported by research
  • Compatible to use for different allergies or dietary restrictions
  • Product is shelf stable and doesn’t require refrigeration
  • Priced reasonably for a probiotic + prebiotic supplement


  • Proprietary blend makes it difficult to evaluate if individual strains are in sufficient amounts to provide benefits
  • Large number of probiotic strains appear to be redundant in purpose
  • Unable to find studies on several specific strains of bacteria to show efficacy

What Is Seed Daily Synbiotic?

The Daily Synbiotic is the first probiotic product developed by Seed with the goal to pioneer microbiome science to improve human and planetary health.

It contains 24 strains of bacteria and a prebiotic (also known as a synbiotic) derived from Indian pomegranate to provide systemic benefits to the body.

A synbiotic is a dietary supplement that contains both a probiotic (beneficial bacteria and yeast) and a prebiotic (food that supports the growth of the beneficial bacteria).

Probiotics and prebiotics are important to maintaining health because they support the microbiota.

The microbiota, or the human microbiome, consists of a complex system of bacteria, viruses, and fungi that have extensive effects on the body.

The microbiome affects systems including immunity, nutrition and vitamin synthesis, fat storage and metabolism, and even behavior.

This probiotic and prebiotic complex claims to not only provide benefits to the gut and microbiota but benefits that extend to the entire body.

Seed Probiotics is reported to aid gastrointestinal health, gut-barrier integrity, immune function, cardiovascular health, dermatological health, and micronutrient synthesis.

The dosage for the Daily Synbiotic is two capsules per day. To optimize the results from this supplement, daily intake is encouraged to maint the presence of probiotics in the gut.

It is also recommended that this supplement should be taken on an empty stomach to prevent early degradation of the capsule and probiotics before they can reach the gut.

Seed was cofounded by Ara Katz and Raja Dhir, and its product formulation is supported by a scientific advisory board.

Seed’s Scientific Advisory Board is made up of well-qualified scientists, researchers, doctors, and authors.

Collectively, their expertise covers a variety of fields, including microbiology, immunology, genetics, molecular biology, pediatrics, gastroenterology, and transcriptomics (the study of RNA transcripts produced by the genome).

The Chief Scientist on the Scientific Advisory Board is Dr. Gregor Reid, Ph.D., MBA, a specialist in microbes, and known for being Chair of the United Nations World Health Organization Expert Panel on Probiotics.

Evaluation of Ingredients

The DS-01 Daily Synbiotic consists of 24 strains of bacteria, providing 53.6 Billion AFU (Active Fluorescent Units).

Digestive Health, Gastrointestinal Immunity, Gut-Barrier Integrity Probiotic Blend (37 Billion AFU)

Bifidobacterium breve SD-BR3-IT: found to decrease pro-inflammatory cytokines, increase anti-inflammatory cytokines, reduce bacterial overgrowth in IBS, and restore the gut barrier. Also found to decrease certain bacteria in children, possibly being effective in improving colic symptoms.

Bifidobacterium longum SD-BB536-JP: a pilot study found that this strain reduces the production of inflammatory cytokines in patients with ulcerative colitis and supports tight junctions in the gut tissue to prevent leaky gut.

Bifidobacterium infantis SD-M63-JP: a randomized trial found that a probiotic containing Bifidobacterium infantis, breve, and longum improved abdominal pain symptoms and quality of life in children with IBS.

Bifidobacterium lactis HRVD524-US (Bl-04): A pilot study found that supplementation with this strain increased serum levels of IgG, the most abundant type of antibody in the body, after receiving a vaccine.

Bifidobacterium breve HRVD521-US: There were no easily available studies on this particular strain, but B. breve is often used in pediatric health to prevent or treat colic, celiac disease, allergy disorders, neurological disorders, and obesity.

Bifidobacterium longum HRVD90b-US: I could not find a study on this B. longum strain, but other strains of B. longum are known to help maintain microbiota diversity, stimulate the immune system, and support gut health.

Bifidobacterium lactis SD150-BE: I was unable to find a study on this particular strain, but B. lactis is found to be beneficial against diarrhea and reducing pathogenic bacteria in the gut.

Bifidobacterium longum SD-CECT7347-SP: A randomized study involving children with newly diagnosed celiac disease found that supplementation with B. longum reduced inflammatory markers and improved gut microbiota composition.

Lactiplantibacillus plantarum SD-LP1-IT: One randomized study found that individuals taking a mixed probiotic of L. plantarum and B. breve or B. animalis reported improvement in the number of bowel movements and decreased abdominal bloating and other symptoms.

Limosilactobacillus reuteri RD830-FR: I could not find a study on this particular strain of bacteria, but the L. reuteri species is known to inhibit pathogenic bacteria, support immune function, and strengthen the gut barrier.

Limosilactobacillus fermentum SD-LF8-IT: An animal study found that other strains of L. fermentum are found to decrease inflammatory cytokines and increase anti-inflammatory cytokines.

Lacticaseibacillus rhamnosus HRVD113-US: I was unable to find studies on this particular strain of L. rhamnousus. It belongs to a group of bacteria that are scientifically backed to support gut health and immunity.

Lacticaseibacillus casei HRVD300-US: I was unable to find a specific study on the HRVD300 strain of L. casei, but it belongs to a well-researched bacteria species that have been used for probiotics or in synbiotics in the treatment and prevention of diseases associated with disturbances to the gut’s microbiota.

Lacticaseibacillus rhamnosus SD-GG-B: This is the world’s most studied probiotic with over 30 years of research and is shown to improve intestinal mucosa, reduce inflammation, improve immune response, and is overall helpful for a variety of gastrointestinal conditions.

Lacticaseibacillus rhamnosus SD-LR6-IT: a pilot study found to reduce bacterial overgrowth and improve gut-barrier integrity in individuals who chronically take proton-pump inhibitor (PPI) medications.

Ligilactobacillus salivarius SD-LS1-IT: when combined with B. breve, it has been shown to inhibit pathogen growth and decrease pro-inflammatory cytokine production in cells from the immune system.

Dermatological Health Probiotic Blend (3.3 Billion AFU)

Bifidobacterium breve SD-BR3-IT: an animal study found that that supplementation with this bacteria strain reduced photoaging of skin caused by UV exposure through maintaining skin hydration, skin thickness, and reduced tight junction damage caused by UV irradiation.

Bifidobacterium longum SD-CECT7347-SP; Bifidobacterium lactis SD-CECT8145-SP; Lacticaseibacillus casei SD-CECT9104-SP: a randomized study on the effects of a mixed probiotic (containing B. longum, B. lactus, and L. casei) on atopic dermatitis in children found significant improvements in symptoms.

Ligilactobacillus salivarius SD-LS1-IT: A randomized trial among adults with atopic dermatitis found that administration of this strain for 16 weeks resulted in positive changes in symptoms, dermatology quality of life index, reduced cytokine production, and decreased pathogenic bacteria in the gut.

Cardiovascular Health Probiotic Blend (5.25 Billion AFU)

Bifidobacterium lactis SD-MB2409-IT: In vivo and in vitro studies in rats with high cholesterol found that administration of this B. lactis strain significantly reduced total and LDL cholesterol.

Bifidobacterium lactis SD-BS5-IT: a meta-analysis of the effects of probiotics and total cholesterol found that strains of B. lactis were effective in reducing serum total cholesterol.

Lactiplantibacillus plantarum SD-LPLDL-UK: a clinical study found that supplementation with this strain decreased LDL cholesterol, total cholesterol, and triglycerides, increased HDL, and reduced systolic blood pressure in individuals with normal to mildly high cholesterol.

Micronutrient Synthesis Probiotic Blend (8.05 Billion AFU)

Bifidobacterium adolescentis SD-BA5-IT (DSM18352): a randomized study found that supplementation with 3 probiotic strains, including B. adolescentis, produced folate in the intestine and increased folic acid concentrations in feces.

Limosilactobacillus reuteri SD-LRE2-IT: research supports this probiotic’s ability to produce vitamin B12 (cobalamin) and folate for use in the body.

Microbiota-Accessible Prebiotic (400 mg)

Indian Pomegranate (Punica granatum with polyphenolic and phenolic bioactive): found to stimulate the growth of bifidobacteria and lactobacilli while inhibiting the growth of pathogenic bacteria in an in vitro study.

Verdict on Claimed Benefits

Below is our summary of the available evidence for the claimed benefits of Seed Daily Synbiotic based on the available research:

Gastrointestinal healthStrong Evidence
Gut-barrier integrityStrong Evidence
Gut immune functionStrong Evidence
Cardiovascular healthStrong Evidence
Dermatological healthStrong Evidence
Micronutrient synthesisStrong Evidence

Side Effects and Safety

As with most probiotics, there may be some slight side effects when starting the Daily Synbiotic.

Within the first 3–5 days, individuals may feel some:

  • Gastrointestinal discomfort
  • Abdominal tightness
  • Mild nausea
  • Stool changes

These symptoms should be resolved within 1–2 weeks of taking Seed Probiotics.

To reduce discomfort when starting this probiotic, take only 1 capsule for the first 3 days, then transition to the full dosage (2 capsules) on Day 4.

The Daily Synbiotic is made for adults ages 18 and over. It is safe to take during pregnancy and while breastfeeding, but it is recommended for anyone to speak with a physician before starting any new supplement.

Seed reports that the Daily Synbiotic can fit into any diet – it is reported to be compatible with vegan, vegetarian, and ketogenic diets.

The Daily Synbiotic is also free from dairy, gluten, soy, GMOs, binders, fillers, preservatives, and the top 14 food allergens as defined by the European Food and Safety Authority (EFSA).


The DS-01 Daily Synbiotic is available as a part of a monthly subscription through their website for $49.99 per month.

Your initial order comes with a refillable glass bottle for future deliveries, a travel vial that can carry a week’s worth of supplements, and literature about Seed’s products.

Shipping is free within the US and is $10 for orders placed outside of the US. These shipping fees can be waived for international customers if participating in their Sustainable Transport Program for 90-day refills (instead of a monthly subscription).

The Seed website offers 15% discounts from the monthly subscription cost for military personnel, first responders, nurses and doctors, and students and teachers.

If you are not satisfied with the Daily Synbiotic within 30 days of delivery, you can receive a refund for the cost of the product minus shipping.

Related: Best Probiotics of 2022, According to Dietitians

How Seed Probiotics Compares to the Competition

Compared to other products, Seed’s Daily Synbiotic contains significantly more strains than most other probiotic blends.

This may not necessarily mean that this blend is better than others due to some of the probiotic strains possibly being redundant or not having much easily accessible research to find their particular benefits.

This probiotic is more convenient due to its ability to remain shelf-stable and not require any refrigeration, unlike some other brands like Florajen.

Daily Synbiotic also differs in that it contains strains that are not only for gut health and immunity but support heart health and skin.

Few probiotics were as comprehensive in the health areas they tackled. Some brands choose probiotics to only focus on a single condition such as general gut health support or skin health instead of the entire body.

As far as cost goes, Seed Probiotics is in the middle of the range for probiotics, considering the number of cultures it provides.

There are some “higher end” probiotics on the market that currently go for $75+ and don’t necessarily provide more cultures.

The Bottom Line

Overall, Seed’s Daily Synbiotic contains a variety of research-backed probiotics that make it worth purchasing.

It is well-priced compared to its competition. Combining a prebiotic with a probiotic makes tending to your gut health a bit easier than having to take multiple supplements.

I do wish there was more research available on specific strains. Also, the proprietary blend of ingredients makes it difficult to know if all 24 bacterial strains are in doses sufficient to provide benefits.

As we continue to learn about the gut microbiota role in whole-body health, having a comprehensive probiotic with useful strains is important.

A Word from Our RD

A healthy microbiota cannot be sustained by only taking a probiotic supplement.

Adding fermented foods to your diet, such as kefir, kimchi, yogurt, and tempeh, can provide a wealth of probiotics.

Also, having a variety of fruits and vegetables provides different prebiotics in amounts to help sustain a healthy balance of bacteria in your gut. 

A registered dietitian can help you find ways to easily add probiotics and prebiotics into your diet.

The microbiota is not fully understood yet. Additional factors that influence its health include age, psychological stress, medication and drug use, physical activity, tobacco use, and alcohol consumption.

Making sustainable healthy lifestyle changes throughout your life can help you maintain a healthy gut that works for you, even without a probiotic supplement.

If you have concerns about your gut health, I recommend speaking with your primary doctor or a gastroenterologist to find the best treatment plan for you.

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