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Seed Probiotic Review: A Product That Earned Our Recommendation

Last Updated on March 1, 2023

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:3.8
  • Ingredient Safety:4.5
  • Customer Service:4.0
  • Value for the Price:5.0

Seed is a high-quality synbiotic (prebiotics + probiotics) that offers many benefits for whole-body health. If it’s within your price point, this is a product worth considering.

Written by
SaVanna Shoemaker, MS, RDN, LD
Registered Dietitian Nutritionist
SaVanna Shoemaker, MS, RDN, LD spent several years working in various dietetic roles and settings, including research, public health, dialysis, and acute care. She became a Registered Dietitian Nutritionist in 2013, while completing her Master of Science degree at The University of Southern Mississippi.
Written by
Kelsey Costa, MS, RDN
Registered Dietitian
Kelsey Costa is a registered dietitian, business owner, writer, and editor with years of experience in health and wellness. She earned a Master of Science in Health and Wellness Management from Merrimack College and completed her dietetic internship with Wellness Workdays, a nationally recognized corporate wellness company.
Medically Reviewed by
Natalie Olsen, MS, RDN, LD, ACSM-EP
Registered Dietitian, Certified Exercise Physiologist
Natalie is a registered dietitian, functional medicine practitioner and certified exercise physiologist with over 15 years experience in the health and wellness industry and holds a Master's degree in Human Nutrition and Functional Medicine through a collaborative program provided by the University of Western States and the Institute of Functional Medicine.
Seed Probiotic Review: A Product That Earned Our Recommendation
Photo by WellnessVerge

Key Takeaways (TL;DR)

  • Seed Daily Synbiotic is a high-quality probiotic and prebiotic supplement that contains several research-supported strains.
  • It offers many benefits for whole-body health, including digestive, skin, and heart health.
  • Seed also appears to be the best synbiotic on the market for those with IBS or IBS-like symptoms due to the brand’s use of non-fermenting prebiotics that won’t irritate the digestive tract.
  • Seed differs from its competitors due to its engineering and the research and quality control that went into the product.
  • Customers are very satisfied with the product, too. Most of the reviews were overwhelmingly positive in regards to the product itself, even if they had some complaints about price or customer service.
  • While Seed Synbiotic supplementation may provide many health benefits, it does not replace the need for a well-balanced diet and a healthy, active lifestyle.

What We Liked

  • Contains research-backed ingredients.
  • Includes third-party testing to ensure quality control.
  • Allergen-free and vegan-friendly.
  • Seed offers aesthetically pleasing packaging while remaining environmentally conscious.

Important Considerations but Not Deal Breakers

  • When starting with Seed, it may cause mild gastrointestinal side effects, but that's common with all probiotic supplements.
  • You must continue taking the supplement long-term to maintain benefits.
  • While Seed is reasonably priced and uses high-quality ingredients, you should factor in the cost since you will have to take it long-term.

Seed in a Snapshot

Seed Daily Synbiotic supplement includes both a probiotic and a prebiotic to improve digestive, immune, heart, and skin health. Probiotics are living “good bacteria” that can help improve your gut microbiome, while prebiotics serve as food for the bacteria in your gut. (1)

Seed Daily Synbiotic is a product of Seed Health, an innovative company founded in 2015 that explores the use of microbes in promoting human health. Their Scientific Advisory Board consists of scientists, researchers, doctors, and authors in microbiology and immunology.

Seed Synbiotic is unique in its “capsule within a capsule” design. This design has an outer capsule that helps protect the probiotics located inside the inner capsule from your stomach acid. This ensures the probiotics are alive when they arrive in your large intestine, so they’re most effective.

Who Is Seed For?

The quantity and variety of our body’s good bacteria (microbiome) significantly impact our physical and mental wellness. Unfortunately, modern-day dieting, lifestyle, environmental factors, and healthcare practices have negatively impacted our body’s natural microbiome.

If you’re dealing with nagging digestive issues or skin problems, you’ll definitely want to consider Seed Daily Synbiotic.

How Do I Take It?

Seed Health recommends starting with a dose of 1 capsule daily for at least the first three days. Then, you may increase to the full dose of 2 capsules (once daily).

Seed Probiotic works best on an empty stomach, taken at least 10 minutes before any meal.

Click to View the Nutrition Facts

Seed Synbiotic contains four unique blends of probiotics, providing a combined 53.6 billion AFU (an estimation of the number of live bacteria per serving).

These blends include:

  • Digestive Health/Gut Immunity/Gut Barrier Integrity Probiotic Blend: 37 billion AFU
  • Dermatological Health Probiotic Blend: 3.3 billion AFU
  • Cardiovascular Health Probiotic Blend: 5.25 billion AFU
  • Micronutrient Synthesis Probiotic Blend: 8.05 billion AFU

Additionally, Seed Synbiotic contains 400 mg of Microbiota-Accessible Polyphenolic Precursors (non-fermenting prebiotics from Indian pomegranate).

If Seed Has a Flaw, It’s the Higher Price

A Seed subscription costs $49.99 monthly for a 30-day supply (60 capsules). This also includes free shipping within the United States. International shipping is $10.

You can get a 15% discount with your first order if you apply our promo code WELLNESSVERGE at checkout.

Your first order arrives as a welcome kit with a refillable glass jar containing a 30-day supply of Seed Synbiotic. The kit also includes a glass travel vial to store your capsules.

For sustainability, your second and subsequent refill orders arrive in a compostable film.

The brand also offers a 30-day risk-free guarantee on your first order. However, you are required to pay for return shipping.

Seed Health’s products are only available on its website.

Seed Package with The Bottle and refill pack
Seed package with the bottle and travel vial pack. Photo by WellnessVerge

Seed Offers Many Benefits for Whole-Body Health

Seed uses well-researched prebiotics and probiotics to promote many health benefits for your overall wellness.

We evaluated a lot of scientific evidence to determine the likelihood of Seed delivering on its promises.

Here are our key takeaways from the research on the ingredients used in Seed Synbiotic and their roles in delivering health benefits:

Digestive Health

Your digestive system is crucial to your overall health as it absorbs the nutrients you ingest and delivers them to the bloodstream and throughout the body. Strong clinical studies demonstrate the benefits of the probiotic species present in Seed Synbiotic to promote digestive health. (2, 3)

Gut Barrier Integrity and Immune Function

The gut barrier is made up of layers, including a thick layer of mucus, lining your digestive tract. It requires the presence of “good” bacteria to function optimally. Additionally, defects in the gut barrier can result in a weakened immune system and contribute to many diseases. Scientific evidence supports the probiotic species in Seed to improve gut barrier integrity and immune function. (4, 5, 6)

Heart Health

High cholesterol can lead to fatty deposits in your blood vessels, negatively affecting your heart health and increasing your risk for diabetes, high blood pressure, and heart disease. The probiotic species present in Seed show positive effects on total cholesterol and may improve heart health. (The amount of time it might take to see results can vary, but taking a probiotic supplement for longer may be more beneficial in lowering cholesterol.) (7)

Skin Health

The probiotic strains present in Seed have been shown to improve skin elasticity, increase skin hydration, and reverse ultraviolet-induced aging, which is caused by exposure to the sun or artificial rays (like a tanning bed). (8)

Micronutrient Synthesis

Micronutrient synthesis is the process of creating vitamins and minerals. Current research shows that the probiotics present in Seed may produce essential vitamins in the human intestines. Gut bacteria can make some vitamins and minerals. (9, 8)

Try Seed Synbiotic

Seed Is Generally Safe, but Consider This

Seed Probiotic may cause mild gastrointestinal side effects such as gas and bloating, which are common to all probiotic supplements during the first few days of taking them. (10)

However, Seed Health has worked to create a gentle supplement for the digestive system. Seed Synbiotic includes non-fermenting prebiotics. These non-fermenting prebiotics are plant-based compounds called polyphenols which are derived from Indian pomegranate. Because of this, side effects may be less likely compared to other supplements containing prebiotics and probiotics.

Seed has been approved by the Food and Drug Administration (FDA) as an investigational new drug for irritable bowel syndrome (IBS). This demonstrates the safety of Seed Synbiotic and the potential for it to be used clinically in the future.

This product is preservative-free and only contains essential ingredients. It’s also free of all major allergens, as well as gluten. Additionally, Seed is free of pesticide residues and compliant with California’s Prop 65, which certifies that it doesn’t expose you to unsafe amounts of harmful chemicals.

This product is intended for anyone over 18 and may be safe to take during pregnancy and while breastfeeding. However, checking with your doctor before taking any new supplements is always best.

Seed Is a Solid Choice When Compared to Alternatives

Seed Synbiotic contains Bifidobacterium and Lactobacillus, two of the most commonly studied and used probiotics. Here’s how Seed compares to two other popular synbiotic brands that use the same two probiotics.

Seed Daily Synbiotic DS-01 Puori SB3 Ritual Synbiotic+
Price $49.99 for a 30-day supply $44.99 for a 30-day supply $50 for a 30-day supply
Lowest Possible Price $49.99 for a 30-day supply $38.24 for a 30-day supply (with subscription) $50 for a 30-day supply (discounts available for bundling with other products)
Shipping Free Free Free
Return Policy 30-day money-back No returns for opened product 30-day money-back
Key Ingredients

Probiotics, Prebiotics

Vitamin C, Probiotics, Prebiotics

Probiotics, Prebiotics, Postbiotic

Form Capsule Powder Capsule
Third-Party Tested Yes Yes Yes
Purchase From Seed On Amazon From Ritual

Expand Below to See the Details of How Each Brand Compares

Vs. Puori SB3

Another safe alternative is a synbiotic supplement manufactured by Puori called SB3. This supplement is $38.24 per month with a subscription.

SB3 is third-party tested by Clean Label Project and certified free of heavy metals, industrial chemicals, and other toxins.

However, it only contains two strains of probiotics. With much fewer probiotic strains, it may not provide as many benefits as Seed Probiotic.

Additionally, Puori doesn’t accept returns for opened products.

Despite this, it may be your best choice if you want a synbiotic that’s Clean Label Project certified and at a slightly lower price point than Seed.

Vs. Ritual’s Daily Synbiotic+

Finally, the multivitamin brand Ritual has released a synbiotic that is comparable in quality and design to Seed Synbiotic.

Their Daily Synbiotic+ also features the capsule-in-capsule design. However, it contains just two bacterial strains — Lactobacillus rhamnosus (LGG) and Bifidobacterium animalis lactis (BB-12).

It also contains a blend of prebiotics and tributyrin (a postbiotic that offers additional gut benefits). (11)

Synbiotic+ is $50 per month with free shipping. They offer a 30-day money-back guarantee for your first new product order.

This supplement may be a good choice for you if you want a synbiotic that also contains postbiotics. It’s comparable in price to Seed.

Read The Full Ritual Synbiotic+ Review

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At WellnessVerge, we only use reputable sources, including peer-reviewed medical journals and well-respected academic institutions.

  1. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics - PubMed:
  2. Probiotics and the Gut Immune System: Indirect Regulation - PubMed:
  3. Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals - PubMed:
  4. The intestinal barrier: a fundamental role in health and disease:
  5. The Probiotic Bacterium Lactobacillus casei Induces Activation of the Gut Mucosal Immune System through Innate Immunity:
  6. Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases:
  7. The effects of probiotics on total cholesterol:
  8. Review: Probiotics in dermatology - Journal of Skin and Sexually Transmitted Diseases:
  9. Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications - PubMed:
  10. Side Effects Associated with Probiotic Use in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - PubMed:
  11. Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD - PubMed: