Evidence Based Research
Our editorial team is made up of expert registered dietitians with extensive, real-world clinical experience who are highly trained in evaluating clinical research.
Read Our Editorial Policy

Seed Probiotic Review: A Solid Synbiotic Backed by Research

Last Updated on October 19, 2022

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:3.8
  • Ingredient Safety:4.5
  • Customer Service:4.0
  • Value for the Price:5.0

Our Takeaway: Seed is a high-quality synbiotic that uses well-researched prebiotics and probiotics that work in harmony to offer many benefits for whole-body health.

Written by
SaVanna Shoemaker, MS, RDN, LD
Registered Dietitian Nutritionist
SaVanna Shoemaker, MS, RDN, LD spent several years working in various dietetic roles and settings, including research, public health, dialysis, and acute care. She became a Registered Dietitian Nutritionist in 2013, while completing her Master of Science degree at The University of Southern Mississippi.
Written by
Kelsey Masso, MS, RDN
Registered Dietitian
Kelsey Masso is a registered dietitian, business owner, writer, and editor with years of experience in health and wellness. She earned a Master of Science in Health and Wellness Management from Merrimack College and completed her dietetic internship with Wellness Workdays, a nationally recognized corporate wellness company.
Medically Reviewed by
Natalie Olsen, MS, RDN, LD, ACSM-EP
Registered Dietitian, Certified Exercise Physiologist
Natalie is a registered dietitian, functional medicine practitioner and certified exercise physiologist with over 15 years experience in the health and wellness industry and holds a Master's degree in Human Nutrition and Functional Medicine through a collaborative program provided by the University of Western States and the Institute of Functional Medicine.

WellnessVerge is reader-supported. When you make a purchase through links on this page, we may earn a commission. Learn More

Seed Probiotic Review: A Solid Synbiotic Backed by Research
Photo by WellnessVerge


  • Contains research-backed ingredients.
  • Includes third-party testing to ensure quality control.
  • Allergen-free and vegan-friendly.


  • More expensive than comparable products.
  • You must continue taking the supplement long term to maintain benefits.

The quantity and variety of our body’s good bacteria (microbiome) greatly impact our physical and mental wellness.

Unfortunately, modern-day dieting, lifestyle, environmental factors, and healthcare practices have negatively impacted our body’s natural microbiome.

If you’re dealing with nagging digestive issues or skin problems, you’ll definitely want to read this review of Seed Daily Synbiotic.

What Is Seed DS-01 Daily Synbiotic?

Seed Daily Synbiotic supplement includes both a probiotic and a prebiotic that aims to improve digestive, immune, heart, and skin health.

Probiotics are living “good bacteria” that can help improve your gut microbiome, while prebiotics serve as food for the bacteria in your gut. (1)

Seed Daily Synbiotic is a product of Seed Health, an innovative company founded in 2015 that explores the use of microbes in promoting human health.

Their Scientific Advisory Board consists of scientists, researchers, doctors, and authors in microbiology and immunology.

Seed Synbiotic is unique in its “capsule within a capsule” design.

This design has an outer capsule that helps protect the probiotics located inside the inner capsule from your stomach acid.

This ensures that the probiotics are alive when they arrive in your large intestine, so they’re most effective.

Seed Health recommends starting with a dose of 1 capsule daily for at least the first three days. Then, you may increase to the full dose of 2 capsules (once daily).

Seed Probiotic works best on an empty stomach, taken at least 10 minutes before any meal.

Customers are very satisfied with the product, too. Most of the reviews I found were overwhelmingly positive in regards to the product itself, even if they had some complaints about price or customer service.

Potential Health Benefits of Seed Synbiotic

Seed Daily Synbiotic is designed to promote the following benefits with its use of probiotics and prebiotics:

  • Digestive health
  • Gut barrier integrity
  • Gut immune function
  • Heart health
  • Skin health
  • Nutrient synthesis

Below we review the research behind the probiotics used in Seed Synbiotic and their roles in delivering health benefits.

May Help with Digestive Health

Species of bacteria in Seed Synbiotic have been shown to support digestive health by relieving constipation, inhibiting the growth of potentially disease-causing microorganisms, and improving the intestinal ecosystem for microbial life. (2, 3)

Your digestive system is crucial to your overall health as it absorbs the nutrients you ingest and delivers them to the bloodstream and throughout the body.

One particular strain of bacteria present in Seed — Bifidobacterium infantis M-63 — has been shown to improve symptoms of irritable bowel syndrome (IBS) in children when taken as part of a probiotic blend. (4)

Seed Health is also currently conducting research into the effects of its synbiotic on adult IBS and on restoring gut health after antibiotic use.


There are clinical studies demonstrating the digestive health benefits of the probiotic species present in Seed Synbiotic.

May Help Improve Gut Barrier Integrity and Gut Immune Function

There are several strains in Seed that work to strengthen the gut barrier as well as improve immune health.

The gut barrier is made up of layers, including a thick layer of mucus, lining your digestive tract. It requires the presence of “good” bacteria to function optimally.

Additionally, defects in the gut barrier can result in a weakened immune system and contribute to a multitude of diseases. (5)

In fact, the gut barrier is where most of the human immune system is located. It’s known as the mucosal immune system (MIS).

Seed Probiotic contains strains of Lactobacillus casei, which may improve mucosal immunity by supporting the growth of “good” bacteria and protecting against pathogens in the gut barrier. (6)

Another largely studied group of species present in Seed Synbiotic — Bifidobacterium — has also been shown to promote the function of the immune system. (7)


Research on the probiotic species in Seed’s Daily Synbiotic supports the claimed benefits of improved gut barrier integrity and gut immune function.

May Help with Cardiovascular Health

High cholesterol can lead to fatty deposits in your blood vessels which can negatively affect your heart health and increase your risk for diabetes, high blood pressure, and heart disease.

A large review of research published in 2018 revealed that probiotics of a wide range of species and strains, in low and high doses, have been shown to significantly reduce total cholesterol. (8)

While it is unclear which strains and doses provide the most cardiovascular health benefits, most probiotics seem to provide at least some cholesterol-lowering benefits.

That is why Seed contains a wide variety of different bacterial strains and a much larger dose of living probiotics than many other competing probiotic supplements.

Also, the higher your total cholesterol is to begin with, the more cholesterol-lowering benefits you may see from taking probiotics.

Additionally, the amount of time it might take to see results can vary, but taking a probiotic supplement for a longer amount of time may be more beneficial in lowering cholesterol.


The probiotic species present in Seed Daily Synbiotic show positive effects on total cholesterol and, therefore, may improve heart health.

May Promote Dermatological Health

Probiotics including Lactobacillus and Bifidobacteria present in Seed Probiotic have been shown to improve skin elasticity, increase skin hydration, and reverse ultraviolet-induced aging, which is caused by exposure to the sun or artificial rays (like a tanning bed).

A review of modern research published in 2019 suggests that using probiotics for skin conditions like atopic dermatitis, acne vulgaris (common acne), and psoriasis may be promising. However, further human research studies are needed. (9)

Overall, studies on probiotic use for skin health have shown mixed results, which depend on the patient’s condition and how the probiotics were used (applied topically or taken orally).


Seed Daily Synbiotic contains probiotics that have been shown to offer some anti-aging effects for the skin, therefore promoting dermatological health.

May Benefit Micronutrient Synthesis

Micronutrient synthesis is the process of creating vitamins and minerals. Some vitamins and minerals can be created by gut bacteria.

Strains of Bifidobacterium present in Seed have been shown to produce vitamin B9 (folate) in the human intestines. (10)

Additionally, a strain of Lactobacillus in Seed, Limosilactobacillus reuteri, has been shown to produce vitamin B12 (cobalamin) in the human intestines. (11)


Current research suggests that the probiotic species and strains present in Seed Daily Synbiotic may produce essential vitamins in the human intestines.

The Evidence Score

Here is our score, based on scientific evidence, of how likely Seed Synbiotic will be effective for its claimed benefits:

Support of gastrointestinal health4.5/5
Support of gut-barrier integrity3.5/5
Support of gut immune function3.5/5
Support of cardiovascular health4.5/5
Support of dermatological health3.5/5
Support of micronutrient synthesis3.5/5

Try Seed Synbiotic

Side Effects and Safety

Taking Seed Probiotic may cause mild gastrointestinal side effects such as gas and bloating, which are common to all probiotic supplements. (12)

However, Seed Health has worked to create a supplement that is gentle on the digestive system. Seed Synbiotic includes uncommon, non-fermenting prebiotics.

The non-fermenting prebiotics in this supplement are plant-based compounds called polyphenols which are derived from Indian pomegranate.

Because of this, side effects may be less likely compared to other supplements containing prebiotics and probiotics.

Seed has been approved by the Food and Drug Administration (FDA) as an investigational new drug for irritable bowel syndrome (IBS).

This demonstrates the safety of Seed Synbiotic and the potential for it to be used clinically in the future.

This product is preservative-free and only contains ingredients that are essential. It’s also free of all major allergens, as well as gluten.

Additionally, Seed is free of pesticide residues and compliant with California’s Prop 65, which certifies that it doesn’t expose you to unsafe amounts of harmful chemicals.

This product is intended for anyone over the age of 18 and may be safe to take during pregnancy and while breastfeeding.

However, it is always best to check with your doctor before taking any new supplements.

Supplement Facts

Seed Synbiotic contains four unique blends of probiotics, providing a combined 53.6 billion AFU (an estimation of the number of live bacteria per serving).

These blends include:

  • Digestive Health/Gut Immunity/Gut Barrier Integrity Probiotic Blend: 37 billion AFU
  • Dermatological Health Probiotic Blend: 3.3 billion AFU
  • Cardiovascular Health Probiotic Blend: 5.25 billion AFU
  • Micronutrient Synthesis Probiotic Blend: 8.05 billion AFU

Additionally, Seed Synbiotic contains 400 mg of Microbiota-Accessible Polyphenolic Precursors (non-fermenting prebiotics from Indian pomegranate).

Seed Synbiotic Cost and Buying Options

Seed Package with The Bottle and refill pack
Seed package with the bottle and travel vial pack. Photo by WellnessVerge

Seed Health’s products are only available on their website through a sustainable, monthly subscription.

A Seed subscription costs $49.99 a month for a 30-day supply (60 capsules). This also includes free shipping within the United States. International shipping is $10.

You can get a 15% discount with your first order if you apply our promo code WELLNESSVERGE at checkout.

Your first order arrives as a welcome kit with a refillable glass jar containing a 30-day supply of Seed Synbiotic. The kit also includes a glass travel vial for you to store your capsules.

For sustainability, your second order and all subsequent refill orders arrive in a compostable film.

You can opt to skip a month or cancel your subscription at any time.

The brand also offers a 30-day risk-free guarantee, allowing you to request a refund within 30 days of the delivery of your first order. However, you are required to pay for return shipping.

Try Seed Today

How Seed Daily Synbiotic Compares to Alternatives

Seed Synbiotic contains Bifidobacterium and Lactobacillus, two of the most commonly studied and used probiotics.

Below we compare Seed to three other synbiotic brands that use the same two probiotics.

Nature M.D. Synbiotic 365

Nature M.D. Synbiotic 365 contains 14 probiotic strains and herbal prebiotics, listed at $39.00 per month with a subscription.

Nature M.D. offers a 60-day risk-free guarantee, so you can test out the product for longer than Seed Synbiotic.

Unlike Seed, Nature M.D.’s product is not California Prop 65 compliant, so consuming Synbiotic 365 can expose you to known toxins, including lead.

If this is important to you, then Seed is a better option.

Puori SB3

Another safe alternative is a synbiotic supplement manufactured by Puori called SB3. This supplement is $38.24 per month with a subscription.

SB3 is third-party tested by Clean Label Project and certified free of heavy metals, industrial chemicals, and other toxins.

However, it only contains two strains of probiotics. With much fewer probiotic strains, it may not provide quite as many benefits as Seed Probiotic.

Additionally, Puori doesn’t accept returns for opened products.

Despite this, it may be your best choice if you want a synbiotic that’s Clean Label Project certified and at a slightly lower price point than Seed.

Ritual Daily Synbiotic+

Finally, the multivitamin brand Ritual has released a synbiotic that is comparable in quality and design to Seed Synbiotic.

Their Daily Synbiotic+ also features the capsule-in-capsule design. However, it contains just two bacterial strains — Lactobacillus rhamnosus (LGG) and Bifidobacterium animalis lactis (BB-12).

It also contains a blend of prebiotics and tributyrin (a postbiotic that offers additional gut benefits). (13)

Daily Synbiotic+ is $50 per month with free shipping. They offer a 30-day money-back guarantee for your first order of any new product.

Daily Synbiotic+ may be a good choice for you if you want a synbiotic that also contains postbiotics. It’s comparable in price to Seed.

Read Further: Ritual Synbiotic+ Review

Comparison Chart

Seed Daily Synbiotic DS-01 Nature M.D. Synbiotic 365 Puori SB3 Ritual Daily Synbiotic+
Price $49.99 for a 30-day supply $45 for a 30-day supply $44.99 for a 30-day supply $50 for a 30-day supply
Lowest Possible Price $49.99 for a 30-day supply $36.67 for a 30-day supply (with subscription) $38.24 for a 30-day supply (with subscription) $50 for a 30-day supply (discounts available for bundling with other products)
Shipping Free Free Free Free
Return Policy 30-day money-back 60-day money-back (with a $9.95 restocking fee) No returns for opened product 30-day money-back
Key Ingredients

Probiotics, Prebiotics

Vitamins, Minerals, Probiotics, Prebiotics

Vitamin C, Probiotics, Prebiotics

Probiotics, Prebiotics, Postbiotic

Form Capsule Capsule Powder Capsule
Third-Party Tested Yes No Yes Yes
Purchase From Seed On Amazon On Amazon From Ritual

The Bottom Line

Seed Daily Synbiotic is a high-quality probiotic and prebiotic supplement that offers many benefits beyond gut health support.

Seed contains several research-supported strains for specific purposes such as digestive, skin, and heart health.

For those with IBS or IBS-like symptoms, Seed also appears to be the best synbiotic on the market due to the brand’s use of non-fermenting prebiotics that won’t irritate the digestive tract.

While other synbiotics may offer some benefits, Seed is different due to its engineering and the research and quality control that went into the product.

If it’s within your price point, I recommend trying Seed because of what we’ve outlined.

Remember that while supplementation with Seed Synbiotic may provide you with many health benefits, it does not replace the need for a well-balanced diet and a healthy, active lifestyle.

Was This Article Helpful?YesNo
Thanks for your feedback!
In a few words, please tell us how this article helped you today.
Please let us know how we can improve this article by selecting your concern below.
Thank You! We appreciate your feedback.
* Please select at least one topic:
Please Note: We cannot provide medical advice. This feedback will help us continue improving your user experience on WellnessVerge.
Please Note: We cannot provide medical advice. This feedback will help us continue improving your user experience on WellnessVerge.
Submit Feedback
Submit Feedback

At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.

  1. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics - PubMed:
  2. Probiotics and the Gut Immune System: Indirect Regulation - PubMed:
  3. Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals - PubMed:
  4. A Mixture of 3 Bifidobacteria Decreases Abdominal Pain and Improves the Quality of Life in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Crossover Trial - PubMed:
  5. The intestinal barrier: a fundamental role in health and disease:
  6. The Probiotic Bacterium Lactobacillus casei Induces Activation of the Gut Mucosal Immune System through Innate Immunity:
  7. Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases:
  8. The effects of probiotics on total cholesterol:
  9. Review: Probiotics in dermatology - Journal of Skin and Sexually Transmitted Diseases:
  10. Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications - PubMed:
  11. Role of Lactobacillus reuteri in Human Health and Diseases:
  12. Side Effects Associated with Probiotic Use in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - PubMed:
  13. Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD - PubMed: