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Ritual Synbiotic+ Review: A Clinically Studied Probiotic Blend for Optimal Gut Health

By Erika Thiede, MS, RDN, CSSD

Published on October 5, 2022

Medically Reviewed by Natalie Olsen, MS, RDN

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:5.0
  • Ingredient Safety:5.0
  • Customer Service:4.5
  • Value for the Price:5.0

Ritual Synbiotic+ is a gut health supplement designed to promote digestive health and immune health. This highly tested formula includes a blend of probiotics, prebiotics, and postbiotic to ensure a well-rounded approach to your gut health.

Written by
Erika Thiede, MS, RDN, CSSD
Registered Dietitian Nutritionist, Integrative and Functional Nutritionist
Erika Thiede is a Registered Dietitian Nutritionist with 10 years of experience in the field of nutrition. While at USC, Erika worked alongside the head sports dietitian, allowing her to realize her true passion was in the field of nutrition and dietetics. Erika completed her master’s degree at Loma Linda University and became a registered dietitian in 2015.
Medically Reviewed by
Natalie Olsen, MS, RDN, LD, ACSM-EP
Registered Dietitian, Certified Exercise Physiologist
Natalie is a registered dietitian, functional medicine practitioner and certified exercise physiologist with over 15 years experience in the health and wellness industry and holds a Master's degree in Human Nutrition and Functional Medicine through a collaborative program provided by the University of Western States and the Institute of Functional Medicine.
Ritual Synbiotic+ Review: A Clinically Studied Probiotic Blend for Optimal Gut Health
Photo credit: iStock.com/LaylaBird


  • Contains prebiotics, probiotics, and postbiotics to improve gut health.
  • Clinically studied ingredients.
  • Product is well researched and may deliver on its claims.


  • May be expensive for some people.
  • Some may experience mild side effects when first starting this supplement.

If you experience frequent bloating, you are not alone.

Bloating is reportedly experienced by 30% of the adult population and is more commonly reported by women. (1)

Digestive discomforts such as bloating may indicate that your gut needs support.

Current research suggests probiotics can play a role in treating gastrointestinal symptoms and may even support the immune system. (1, 2)

Ensuring optimal gut health is essential for anyone wanting to take steps towards improving their overall health and well-being.

That’s why products like Ritual’s Synbiotic+ come to market to help users address these common concerns.

This article will review Ritual Synbiotic+ and help you understand how it works, its potential benefits, safety concerns, cost, and whether it’s the right choice for you.

What Is Ritual Synbiotic+?

Ritual Synbiotic+ is a gut health supplement that aims to support optimal gut health and your immune system with its 3-in-1 blend of clinically studied prebiotics, probiotics, and postbiotic.

Your microbiome consists of microbes that are both helpful and potentially harmful. Tt is critical to keep them balanced for ideal health.

The supplement is backed by science and delivers a highly tested product emphasizing ingredients that can be traced to the source.

Probiotics are important bacteria in the digestive tract that are known to improve digestive health and support a healthy immune function. (3)

Prebiotics act as fuel for probiotics, helping the essential bacteria grow.

Postbiotics are produced by the fermentation process carried out by beneficial bacteria. (4)

Understanding how Ritual Synbiotic+ May Help You

When taken daily, Ritual Synbiotic+ claims to do the following:

  • Decrease bloat.
  • Maintain good bacteria growth.
  • Improve gut barrier health.
  • Increase immune health.

Below we will review each of these claimed benefits, their respective ingredients, and the available scientific research.

Decreased Bloat

Ritual Synbiotic+ includes 11 billion CFU of a probiotic blend to support GI discomforts such as bloating, gas, and diarrhea.

CFU (colony-forming units) refers to how many live bacteria you are ingesting and may help determine the product’s effectiveness.

Ritual’s blend includes two widely studied probiotics — Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis.

Research has found L. rhamnosus to be highly effective in decreasing bloat and abdominal pain. (5)

L. rhamnosus can survive the acidity of the stomach, making it an ideal probiotic to reach the intestines where it will grow. (6)

Additionally, in a review of 27 studies, it was found that Bifidobacterium animalis ssp. lactis may improve the frequency of bowel movements and improve stool consistency. (7)

Furthermore, studies show the combination of Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis may be a helpful treatment for adults with IBS, including symptoms of constipation. (5)

A dose ranging from 10 million to 10 billion CFU per day for at least 1–4 weeks has shown to be effective in most cases of GI distress, such as diarrhea, constipation, bloating, and gas. (8, 9)

This is especially helpful after antibiotic use, which alters the amount of overall bacteria in the gut, including good bacteria. (8, 9)

Ritual Synbiotic+ offers a dose of 11 billion CFU a day and has a delayed-release capsule to ensure the probiotics reach your intestines, where they will be most beneficial.

Finally, a noteworthy aspect of Ritual Synbiotic+ is the research on the supplement. The study was not done on humans but was done in vitro. This means it was done in a test tube or petri dish that modeled the human digestive tract.

Ritual’s extensive testing and blend of two highly tested probiotics make their Synbiotic an excellent choice for anyone looking for support against bloat and mild GI discomforts.


Ritual Synbiotic+ uses a blend of probiotics that has been clinically proven to support relief of occasional bloating, gas, and diarrhea.

Maintain Good Bacteria Growth

Ritual Synbiotic+ contains a prebiotic blend called PreforPro®, which is designed to remove undesirable gut bacteria and support good bacteria growth.

The formula includes four varieties of prebiotics:

  • LH01-Myoviridae
  • LL5-Siphoviridae
  • T4D-Myoviridae
  • LL12-Myoviridae

Prebiotics are critical for helping the essential bacteria grow.

These specific prebiotics have a unique ability to subtly and selectively modify the gut microbiota. (10)

In a small study of 43 adults, participants were asked to take a 15 mg dose of PreforPro®. Results showed a decrease in harmful bacteria such as E.coli and other bacteria linked to inflammation in the intestines. (10)

While the study was small, it offers positive conclusions about using this prebiotic blend.

Additional research found PreforPro® in combination with Bifidobacterium animalis ssp. lactis showed more significant benefits in balancing bacteria growth. (11)

Ritual’s Synbiotic contains 15 mg of PreforPro® with Bifidobacterium animalis ssp. lactis to support an optimal balance of good gut bacteria.


Ritual Synbiotic+ prebiotic and probiotic blend may help support good bacteria growth.

Gut Barrier Health

Ritual Synbiotic includes butyrate, a postbiotic that may support a healthy gut barrier function.

Research has found that butyrate enhances intestinal barrier function and immunity with anti-inflammatory properties. (12)

Additionally, butyrate serves as the primary nutrient to the cells in our colon, supporting balance within the gut and protecting against dysbiosis. (13, 14)

Dysbiosis in the gut refers to an imbalance in the gut microbiota. It is thought to lead to inflammatory bowel disease, diabetes, obesity, and even cancer. (15)

Ensuring a healthy gut barrier is critical to overall health and wellness.

Ritual Synbiotic+ contains 300 mg of butyrate in the form of Tributyrin, designed to support an optimal gut barrier.


Ritual Synbiotic+ contains butyrate, a postbiotic known to support a healthy gut barrier. A healthy barrier is critical to overall health and protecting against dysbiosis.

Immune Support

Ritual’s Synbiotic may help support immune health by promoting a healthy gut environment.

It is estimated that 70%–80% of immune cells exist in the gut. (16)

Research has found that probiotic consumption may activate immune cells and promote a better immune response(17)

Additionally, clinical studies have shown probiotics protect against infection by suppressing the growth of potentially dangerous bacteria. (17)

Maintaining healthy bacteria growth and balance is critical for human health.

It may protect against the development of chronic diseases and health issues, including metabolic disease, depression, gastrointestinal disorders, and colorectal cancer. (18)

By supporting optimal gut health, probiotic consumption may be an appropriate way to support overall immune health.


Ritual Synbiotic+ provides essential probiotics for supporting gut health and immune health.

The Evidence Score

Here is our score, based on scientific evidence, of how likely Ritual Synbiotic+ will be effective for its claimed benefits:

Decrease bloat5/5
Maintain good bacteria growth5/5
Gut barrier health5/5
Immune support5/5

Nutrition Information, Dosage, and How to Take

The recommended dosing for Ritual Synbiotic+ is one capsule daily, morning or night.

Nutrition information includes:

  • Calories: 5
  • Probiotic Blend: 120 mg, 11 billion CFU Lactobacillus rhamnosus (LGG), Bifidobacterium animalis ssp. lactis (BB-12)
  • PreforPro®: 15 mg — LH01-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, LL12-Myoviridae
  • Tributyrin (as CoreBiome®): 300 mg

Safety and Side Effects

While side effects are not widely reported, some people may deal with mild side effects from probiotic supplements, such as diarrhea and bloat –– especially when you just start taking probiotics.

Probiotics are generally safe for healthy adults. However, it is always best to review with your physician before beginning supplementation.

Additionally, some probiotics may worsen your condition if you are immunocompromised or suffer from GI conditions.

Ritual Synbiotic+ is suitable for pregnant, nursing, and individuals with diabetes.

The supplement is vegan, non-GMO, gluten-free, and free of major allergens. Ritual Synbiotic+ has undergone clinical studies and third-party testing to ensure purity and potency.

Cost and Where to Buy

Ritual Synbiotic+ is not sold in stores and must be purchased directly from their online store at the brand’s official website at ritual.com.

A 30-day supply costs $50 plus shipping.

If you enjoy the product, you can join a monthly subscription and receive free shipping, a money-back guarantee, and easy cancellation.

Non-subscription purchases are eligible for a refund, with proof of purchase, within 30 days from the date of purchase.

Try Ritual Synbiotic+

How Ritual Synbiotic+ Compares to Other Brands

Ritual Synbiotic+ is a unique product with the traceability of ingredients and research to support its claims.

While not all probiotics are backed by research, the most similar brands include Seed Daily Synbiotic and Ther-biotic® Synbiotic.

Seed Daily Synbiotic

Seed’s probiotic is a blend of 24 clinically studied probiotic strains and a prebiotic.

The strains are shown to support:

  • Digestive Health
  • Skin Health
  • Nutrient Synthesis
  • Heart Health

Like Ritual, Seed Daily Synbiotic has undergone third-party testing to ensure purity and potency.

Seed is vegan, free of major allergens, and includes 53.6 billion AFUs. AFU refers to living and viable bacteria in a probiotic (it is similar to CFU).

Compared to Ritual Synbiotic+, Seed Daily Synbiotic contains a wider variety of probiotics in its supplement. However, it does not contain a postbiotic.

Seed costs $49.99 for a month’s supply, including shipping and a free travel vial.

If you are looking for a more comprehensive blend of probiotics, Seed Daily Synbiotic is a great choice.

Read Full Seed Review

Klaire Labs Ther-Biotic® Synbiotic

Ther-Biotic Synbiotic contains a blend of seven probiotics and a prebiotic to support microbiome health.

The blend claims to support:

  • Immune Health
  • Cardiovascular Health
  • Gut Health
  • Inflammation Support

The product contains 50 billion CFU of probiotics and Sunfiber as the prebiotic.

Like Ritual, the product is free of common allergens, contains a delayed released capsule, and the company values transparency.

Ther-Biotic Synbiotic is available for purchase on Amazon and in some retail stores at the following prices:

  • $29.99 for a 15-day supply
  • $49.99 for a 30-day supply
  • $89.99 for a 60-day supply

Ther-Biotic Synbiotic is a good option for anyone looking for a probiotic supplement with a greater number of CFU than Ritual.

Comparison Table

Ritual Synbiotic+ Seed Daily Synbiotic Klaire Labs Ther-Biotic Synbiotic
Regular Price $50/month + shipping $49.99/month $49.99/ month
Discounted or Subscription Price $50/month + free shipping $49.99/month No subscription available
Shipping Dependent on location Free shipping Dependent on location
Returns 30-day money back 30-day money back 30-day money back
Key Ingredients

Probiotic blend including Lactobacillus rhamnosus and Bifidobacterium animals


Prebiotic blend as PreforPro®


Postbiotic as Tributyrin


Probiotics including Bifidobacterium longum and Bifidobacterium breve



Probiotics including Lactobacillus plantarum and Bifidobacterium lactis


Prebiotic Sunfiber

Third-Party Tested
Clinical Studies
Form Pill Pill Pill
Purchase Visit Ritual.com Visit Seed.com See Amazon

Frequently Asked Questions

How should I take Ritual Synbiotic+?

Ritual Synbiotic+ is just one capsule daily and can be taken morning or night. The supplement can be taken with or without food. No refrigeration is required.

Is there an adjustment period?

Some individuals may experience an adjustment period. You may experience minor gas, bloating, or stomach gurgling during this time, which should subside with ongoing use.

How does the subscription work?

Each month you will receive an email a few days before your next shipment is sent and before you are charged. You can rush, delay an order, or cancel your subscription at that time.

Will I feel the effects?

Some individuals may feel changes in their GI health within 2–4 weeks of consistent use, while others may not feel any effects. Not feeling the effects does not mean the supplement is not working.

The Bottom Line

Ritual Synbiotic+ is an excellent way to start improving your gut health, including symptoms like bloat and GI upset.

Ritual’s blend of probiotics, prebiotics, and postbiotic is highly tested, traceable, and offers excellent value for anyone looking to support their gut and immune health.

To see optimal results from this supplement, you should take the product daily, combined with a well-balanced diet and lifestyle.

When using the company’s subscription service, the cost of Synbiotic+ is similar to comparable brands, making it a great value, and you get the additional benefit of free shipping.

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At WellnessVerge, we only use reputable sources, including peer-reviewed medical journals and well-respected academic institutions.

  1. Bloating and Abdominal Distension: Clinical Approach and Management - PMC:
  2. Beneficial Effects of Probiotic Consumption on the Immune System - PubMed:
  3. The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss - PMC:
  4. Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond - PMC:
  5. Nutrients | Free Full-Text | Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis | HTML:
  6. Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB – Wiley Online Library:
  7. Effects of Bifidobacterium animalis subspecies lactis supplementation on gastrointestinal symptoms: systematic review with meta-analysis | Nutrition Reviews | Oxford Academic:
  8. Choosing an appropriate probiotic product for your patient: An evidence-based practical guide - PMC:
  9. Probiotics - Health Professional Fact Sheet:
  10. PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults - PMC:
  11. Nutrients | Free Full-Text | PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota in Healthy Adults:
  12. Butyrate: A Double-Edged Sword for Health? | Advances in Nutrition | Oxford Academic:
  13. Colonocyte metabolism shapes the gut microbiota - PMC:
  14. The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation - PMC:
  15. Current understanding of dysbiosis in disease in human and animal models - PMC:
  16. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies - PubMed:
  17. Beneficial Effects of Probiotic Consumption on the Immune System - FullText - Annals of Nutrition and Metabolism 2019, Vol. 74, No. 2 - Karger Publishers:
  18. Gut Microbiome: Profound Implications for Diet and Disease - PubMed: