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Bio-X4 Review: Likely Effective, but Requires Consistency and Time

By Anastasia Climan, RDN, CD-N

Medically Reviewed by Natalie Olsen, MS, RDN

Last Updated on March 13, 2023

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:4.4
  • Ingredient Safety:4.5
  • Customer Service:5.0
  • Value for the Price:3.5

Bio-X4 is a comprehensive supplement for digestion and metabolism that may be worth trying if you have issues like gas, bloating, and unhealthy cravings. This review will help you decide if it’s right for you.

Written by
Anastasia Climan, RDN, CD-N
Registered Dietitian Nutritionist
Anastasia Climan is a registered dietitian whose career progressed into public health, corporate wellness, and private practice roles. She earned a Bachelor of Science from the University of Connecticut's Coordinated Undergraduate Dietetics Program in 2011. She's led wellness initiatives on HIV/AIDS, children's health, and diabetes.
Medically Reviewed by
Natalie Olsen, MS, RDN, LD, ACSM-EP
Registered Dietitian, Certified Exercise Physiologist
Natalie is a registered dietitian, functional medicine practitioner and certified exercise physiologist with over 15 years experience in the health and wellness industry and holds a Master's degree in Human Nutrition and Functional Medicine through a collaborative program provided by the University of Western States and the Institute of Functional Medicine.
Bio-X4 Review: Likely Effective, but Requires Consistency and Time
Photo by WellnessVerge

Key Takeaways (TL;DR)

  • Bio-X4 contains well-researched ingredients that may benefit digestion, especially when taken with a healthy lifestyle.
  • This supplement is for anyone who struggles with bloating, diarrhea, constipation, and cravings for unhealthy food.
  • Bio-X4 may not work immediately. You will need to give it a couple of months to experience its full potential.
  • Overall, customers seem happy with the product and say it helps them stay regular and better handle unhealthy food cravings. Most reviewers like how it reduces bloating and cravings for sweets, but not too many people report significant weight loss.
  • The price may be high for some, but it may be worth it if it solves your digestive concerns. Also, using a subscription saves you a meaningful amount.
  • The ingredients in Bio-X4 are unlikely to cause significant side effects, but you may notice some digestive changes when you first start taking it.

What Bio-X4 Gets Right

  • Uses ingredients that have established benefits for digestion and metabolism.
  • The product is third-party tested for quality and purity.
  • Offers a generous 90-day refund guarantee that allows you to test the product with little risk.
  • The brand encourages a healthy lifestyle to experience the most benefit from Bio-X4.

Important Considerations

  • You need to take the product consistently three times a day, which may take some time to get used to.
  • It might take several months before you notice any benefits.
  • The product must be taken consistently to experience benefits, so ongoing monthly costs should be considered to ensure it fits your budget.

Bio-X4 at a Glance

Bio-X4 from Nucific is a dietary supplement designed to support various aspects of the digestive system and boost metabolism.

It has digestive enzymes to break down food, probiotics to improve digestion and bowel movements, and other ingredients, including green tea extract and Slimaluma, that may speed up the metabolism and prevent fat gain.

Taking Bio-X4 with each meal is designed to change how your body digests food for the better. Previous “trouble foods” can pass through your system more efficiently, so you can have regular bowel movements and fewer unpleasant symptoms like gas and bloating.

How to Take This Supplement to Experience Benefits

The recommended dose of Bio-X4 is one capsule, three times per day, with meals. However, the manufacturers say you can increase your intake to two capsules per meal, not exceeding six daily capsules.

If you’d like to see how Bio-X4 works for you, you should start with a 90-day supply because the manufacturers advise that it can take three months of consistent use before you see the full benefits.

Additionally, most research shows that it can take 2–6 weeks to start seeing results from taking probiotics.

You may need to keep it in plain sight at the dining table or set a reminder on your phone to take it with each meal. After you get in the habit of taking Bio-X4 three times a day, pay attention to how you feel.

If you’re getting to the end of your last bottle and are not pleased with the effects, contact the manufacturer about returning the empty bottles for a refund.

See the Nutrition Facts

Each capsule contains the probiotic blend, the digestive enzyme blend, the weight management blend, and the craving control blend.

Probiotic Blend, 4 billion CFU

The probiotic blend includes consists of:

  • Lactobacillus Blend: L. acidophilus, L. rhamnosus, and L. plantarum
  • Bifidobacterium Blend: B. lactis and B. animalis

Digestive Enzyme Blend, 43 mg

The digestive blend is a combination of:

  • Amylase
  • Bromelain
  • Lipase

The bromelain comes from pineapple, and the other two enzymes are sourced from fungus.

Weight Management Blend, 100 mg

The weight management blend is 100 milligrams of green tea extract with 50% of the active compound EGCG.

Cravings Control Blend, 166 mg

The cravings control blend is a trademarked product from the plant Caralluma Fimbriata. The Bio-X4 makers call this formula Slimaluma.

Inactive Ingredients

  • Vegetable cellulose
  • Microcrystalline cellulose
  • Stearic acid
  • Silica

One-Time Purchase Price Is High; a Subscription Is More Cost-Effective for Regular Use

Quantity Regular One-Time Purchase Promo Price
1 Bottle (1-month supply) $99 $49
3 Bottles (3-month supply) $261.36 $129
6 Bottles (6-month supply) $487.08 $240

Bio-X4 is only available through Nucific’s website. You can’t purchase it in stores or on third-party sites. Shipping is free in the US for any purchases over $50.

If you’re unhappy with Bio-X4, you can return it for a full refund within 90 days. The terms state that you can use up all of the product before making your decision and send back the empty bottle for your money back.

Try Bio-X4

Bio-X4 May Offer Digestive Support for a Variety of Health Benefits

Bio-X4 is designed to deliver the following health benefits:

  • Manage cravings
  • Promote weight management
  • Support digestion
  • Boost metabolism

The unique formulation of Bio-X4 has not been tested as a whole. However, the digestive enzymes, probiotics, green tea extract, and Caralluma Fimbriata that it contains have been individually evaluated in various scientific studies. Here’s our summary of the evidence with key takeaways for each claimed benefit.

Managing Cravings

Slimaluma (Caralluma Fimbriata) is a popular medicinal plant traditionally known as an appetite suppressant. Some studies show that this ingredient may help reduce unhealthy food cravings by helping control appetite and reduce body weight. However, there were also mixed results. (1, 2, 3)

Promotes Weight Management

BIO-X4 contains ​​Caralluma Fimbriata and green tea extract (50% of it is EGCG), which have studies (although some mixed) showing that these ingredients help promote healthy weight management.

Green tea extract improves the body’s ability to break down body fat during steady-state exercise. Studies have shown that supplementing green tea extract leads to significant weight loss and other health benefits, such as lowering cholesterol. (4, 5, 6)

Healthy Digestion

Research shows that probiotics are generally beneficial for digestive symptoms such as diarrhea and constipation and may help with irritable bowel disease, diarrhea, and bloating. Specifically, Bio-X4 contains Lactobacillus and Bifidobacterium, two of the most well-researched probiotics. (7, 8, 9)

Boosts Metabolism

There’s evidence that green tea extract has metabolism-boosting effects, promoting fat breakdown and stimulating fat-burning by producing body heat. (10, 6)

There are no clear dosing guidelines for EGCG. Still, studies show a wide range of doses between 100–856 milligrams for boosting metabolism. The amount of EGCG (green tea extract) in Bio-X4 should be sufficient to offer benefits. A day’s worth of Bio-X4 contains 150–300 milligrams of EGCG (depending if you take one or two pills with each meal). (10, 5)

Nucific BIO-X4 capsules
Photo by WellnessVerge

Bio-X4 Is Generally Safe for Most People

Bio-X4 is a generally safe supplement unlikely to cause lasting or serious side effects. However, people with a weakened immune system, diabetes, pregnancy, or nursing may want to avoid it.

Since digestive enzymes and probiotics help your body digest food more efficiently, you may head to the bathroom more frequently.

Probiotics are generally considered safe, and more and more research is being done on specific strains and doses. The strains found in Bio-X4 are unlikely to cause harm for healthy people. (11)

However, people with a compromised immune system could be at risk of harmful effects from probiotics. If you have a compromised immune system, it is best to speak with your healthcare provider before taking supplements like Bio-X4. (12)

The amount of green tea extract in Bio-X4 is considered safe and unlikely to cause adverse side effects. According to the European Food Safety Commission, supplements with less than 800 milligrams of ECGC from green tea extract are unlikely to cause a problem. (13)

Each capsule of Bio-X4 has 100 milligrams of green tea extract with 50% ECGC. Therefore, even taking the maximum dose of six pills per day would provide 300 milligrams of ECGC (which is well within the safe limit).

However, green tea extract may interfere with certain medications. Always speak with your doctor before adding a supplement that includes this ingredient. (14)

A review of several studies using the herbal extract found in Slimaluma reported the main side effects as constipation, diarrhea, nausea, and rashes. (1)

It’s best not to start a new dietary supplement while pregnant or nursing unless specifically recommended by your healthcare provider. People with diabetes should also use caution with supplements and discuss Bio-X4 with their doctor before taking it.

How Bio-X4 Compares to Alternatives

At its core, Bio-X4 is a probiotic supplement that includes digestive enzymes and several additional metabolism-boosting ingredients. Its ingredients are also third-party tested for quality and purity. These factors make Bio-X4 unique.

You can find probiotic and digestive enzyme blends for less money than Bio-X4, but they don’t have additional ingredients that Bio-X4 contains, and their probiotic content is lower.

Tip: If Bio-X4 is outside your budget, consider a regular probiotic supplement, which is usually cheaper. Use our list of the Best Probiotics to find the right one for you.

Here’s how Bio-X4 compares to two similar products from well-known brands that combine probiotics and digestive enzymes.

Nucific Bio-X4 Life Extension Enhanced Super Digestive Enzymes and Probiotics Enzymedica Digest Gold Probiotics
Cost for a 1-Month Supply




Available Discounts

Receive an additional 10% off when you subscribe

Save 7% on 2+ bottles and 14% on 4+ bottles

Save 20% when you subscribe

Return Policy Can return it after 90 days for a full refund even if you used all the product Return any product within 12 months for a refund or store credit (unclear if refunds apply to a product that’s been used) Full refund (minus shipping) within 30 days if you provide the receipt.
Main Ingredients

5 Strains of Probiotics (4 billion CFU), 3 Digestive Enzymes, Green Tea Extract, and Camulluna Fibriata (herb)

1 Strain of Probiotics (1 billion CFU), 10 Digestive Enzymes, and “Prebiotics” (to feed the bacteria)

9 Strains of Probiotics (500 million CFU) and 13 Digestive Enzymes


Improves Digestion, Raises Metabolism

Promotes Better Digestion, Promotes Nutrient Absorption

Enhances Digestion, Enhances Immunity, Enhances Energy Levels

Third-Party Quality Tested Yes No, in-house quality testing only No, not mentioned by the manufacturer
Allergen and Special Diet Considerations

Allergen-Free, Gluten-free

Non-GMO, Vegetarian

Vegetarian, Dairy-Free, Gluten-Free, Non-GMO, Soy-Free

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At WellnessVerge, we only use reputable sources, including peer-reviewed medical journals and well-respected academic institutions.

  1. The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement: a systematic review and meta-analysis of clinical trials - PubMed:
  2. Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women - PubMed:
  3. The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults - PMC:
  4. Nutrients | Free Full-Text | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals | HTML:
  5. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial - PubMed:
  6. [Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review] - PubMed:
  7. Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives - PMC:
  8. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study - PubMed:
  9. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects - PubMed:
  10. The Anti-Obesity and Health-Promoting Effects of Tea and Coffee - PMC:
  11. Probiotics - Health Professional Fact Sheet:
  12. Probiotics: What You Need To Know – NIH:
  13. Scientific opinion on the safety of green tea catechins – EFSA:
  14. Drug Interactions between green tea and simvastatin – Drugs.com: