Evidence Based Research
Our editorial team is made up of expert registered dietitians with extensive, real-world clinical experience who are highly trained in evaluating clinical research.
Read Our Editorial Policy

Lipozene Review: Does It Work for Weight Loss? Our Dietitian Explains

Written by Emily Hirsch, MS, RD

Reviewed by Anthony Dugarte, MD 

Last Updated on July 19, 2021

Our Expert Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:2.7
  • Ingredient Safety:4.0
  • Value for the Price:1.0
  • Brand Transparency:3.0

In a sea of weight loss supplements, Lipozene joins the ranks claiming to decrease your calorie intake, thus helping you lose weight naturally. Although we all want the secret to effortless weight loss, the ingredients in Lipozene fall flat when evaluated scientifically.

Lipozene Review: Does It Work for Weight Loss? Our Dietitian Explains


  • Can potentially decrease appetite and reduce overeating due to the increased fiber intake
  • Has the potential to promote gut health


  • Lacking in independent, sound research
  • Potential for unpleasant side effects
  • Expensive compared to other glucomannan supplements

What Is Lipozene?

Lipozene is a weight loss supplement promising to help people lose weight without changing their eating habits or lifestyle.

The only active ingredient in Lipozene is glucomannan.

Glucomannan is a natural, water-soluble dietary fiber obtained from the roots of the konjac plant, also known as elephant yam.

The glucomannan fiber is extremely viscous and has an amazing ability to absorb water. A single capsule can turn a full glass of water into a gel.

When ingested with water, glucomannan creates a thick, gel-like substance in the stomach, helping people feel fuller faster.

Lipozene is manufactured by the Obesity Research Institute, a California-based company founded in 2003. The Obesity Research Institute has created various products within the weight loss space.

How Could Lipozene Promote Weight Loss?

Based on many research studies, fiber intake is linked to lower body weight.

Considering the high-fiber nature of glucomannan, Lipozene may promote weight loss in the following ways:

Keep You Feel Full Longer

Due to its water-absorbing properties, glucomannan will attract water and expand in the stomach.

This process will slow the rate of digestion, helping the stomach to feel fuller, so you eat less.

Reduce Your Dietary Calorie Intake

Glucomannan may decrease the absorption of other calorie-containing nutrients, like protein and fat.

This would potentially mean absorbing fewer calories from the food you eat.

May Promote Gut Health

Increasing fiber intake promotes good bacteria in the gut. Enhancing the gut microbiome may lead to weight loss.

According to a recent review of the research, changing the gut microbiome may be an important tool in the treatment of obesity and lead to reductions in BMI, body weight, and fat mass.

Does Lipozene Actually Work?

The manufacturers of Lipozene promise that you will lose weight and body fat. They claim to have completed clinical studies using the product with great success.

The website states that “Overweight persons in the active group and all persons in the first study lost on average at least 4.93 more pounds than placebo.”

Additionally, the study claims that 78% of each pound lost was pure body fat.

Unfortunately, as remarkable as these numbers may sound, the Lipozene study is limited in several ways.

There is no information on how body fat was measured, no information on the calorie intake or exercise regimen in either group.

Additionally, this study was never peer-reviewed. Peer-reviewed studies meet certain standards of scientific quality and are considered a trusted form of scientific communication.

Conversely, a peer-reviewed study from the Journal of Obesity found that Glucomannan supplements administered over 8 weeks did not promote weight loss or significantly alter body composition or hunger and fullness.

Another study concluded that glucomannan did promote limited weight loss, but researchers found no change in long-term body mass index (BMI).


While some of the research on glucomannan is promising for short-term weight loss success, according to the National Institutes of Health (NIH), glucomannan may have little to no effect on body weight or successful long-term weight management.

Verdict on Claimed Benefits

Below is our summary of the available evidence for the claimed benefits of Lipozene based on the available research:

  • Helps reduce weightModerate Evidence
  • Helps reduce body fatLimited Evidence
  • Safe and effectiveModerate Evidence

Side Effects and Dosage

According to the National Institutes of Health (NIH), the side effects of taking glucomannan may include loose stools, gas, diarrhea, constipation, and abdominal discomfort.

Since Lipozene is just a fiber supplement, there is little concern for side effects beyond gastrointestinal problems.

The manufacturers recommend taking 2 pills 30 minutes before each meal, for a recommended maximum dose of 6 pills per day.

Each Lipozene pill contains 0.75 grams of glucomannan, so taking 2 pills would provide 1.5 grams of glucomannan.

The recommended dosage is the equivalent of taking 4.5 grams of glucomannan a day, which exceeds the amount known to be effective for weight loss

Every serving of Lipozene should be accompanied by at least 8 ounces of water.

It is important to talk to your healthcare provider before taking Lipozene or any other supplement to ensure its safety for you.

Cost and Where to Buy

When purchased directly from the manufacturer, a bottle of Lipozene is $29.95, which includes free shipping and handling.

Your total monthly cost of Lipozene will depend on how much you take. Based on Lipozene’s recommended dosage (2 capsules, 3 times per day), a one-month supply would cost roughly $90.

Lipozene does offer a 30-day money-back guarantee.

Lipozene is also available from Amazon and CVS at a lower cost.

How Lipozene Compares to Alternatives

Ninety dollars per month for Lipozene is very steep compared to other supplements with a similar active ingredient.

A wide variety of glucomannan supplements are available at most stores and online retailers for a fraction of the cost of Lipozene.

For example, NOW Foods offers a glucomannan supplement for $8.39 for a month’s supply.

You may also consider Nature’s Way Glucomannan Root, a natural supplement that costs only $14.66 for 100 capsules. With a recommended dosage of 2–3 capsules per day, the bottle should last 4–6 weeks.

Another low-cost glucomannan supplement is NutriGold Glucomannan GOLD. A bottle containing 120 pills is $16.49, and the recommended dosage is 2 capsules per day. The bottle should last roughly 2 months.

The Bottom Line

Imagine taking a few pills, and suddenly the stubborn fat on your body melts away?

Unfortunately, Lipozene is not that miracle pill many people are longing for.

While some science supports short-term weight loss resulting from taking this supplement, there have been no actual long-term scientific studies on Lipozene itself.

For long-term success, no dietary supplement can replace healthy weight loss habits.

A Word from Our RD

Any company that claims their product will help you lose weight without diet or lifestyle changes should be met with a great deal of skepticism.

Even though you won’t see immediate results, eating a healthy, well-balanced diet, reducing calorie intake, and participating in regular physical activity is a tried and true way to help with weight management.

Until that miracle pill is developed, we’re all at the mercy of a healthy lifestyle to reach our weight goals.

Was This Article Helpful?YesNo
Thanks for your feedback!
In a few words, please tell us how this article helped you today.
Please let us know how we can improve this article by selecting your concern below.
Thank You! We appreciate your feedback.
* Please select at least one topic:
Please Note: We cannot provide medical advice. This feedback will help us continue improving your user experience on WellnessVerge.
Please Note: We cannot provide medical advice. This feedback will help us continue improving your user experience on WellnessVerge.
Submit Feedback
Submit Feedback

At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.