Lipozene Review: Does It Actually Work for Weight Loss?
Medically Reviewed by Yasmine S. Ali, MD, MSCI, FACC, FACP
Last Updated on November 21, 2022
Lipozene is a popular weight-loss supplement claiming to help you lose weight with its main active ingredient, glucomannan, a soluble fiber. Research shows that fiber can aid in weight loss, but it's only for the short term and does not replace a healthy diet.
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Diet pills are an attractive option for many people who have difficulty losing weight.
Many manufacturers of diet pills offer a fast way for you to lose weight without making other lifestyle changes, which may sound appealing to some.
Lipozene is one of the popular supplements that claim to help with weight loss.
But, does a supplement like Lipozene actually work, and is it safe? This review discusses the research behind the supplement’s ingredients.
The proprietary blend used in Lipozene is from the root of the konjac plant, Amorphophallus konjac — also called elephant yam. This contains a water-soluble fiber called glucomannan. (3)
Glucomannan absorbs about 50 times its weight in water and forms a gel-like substance. A small amount of glucomannan can turn 8 ounces of water into gel. In food, glucomannan is used as a thickener. (4)
Some potential benefits of glucomannan include:
- Keeping You Full: The manufacturers of Lipozene claim that the proprietary fiber blend can increase feelings of fullness that can last for hours.
- Reducing Calorie Intake: Improving feelings of fullness may help decrease total calorie intake and increase weight loss goals more quickly, and in a natural way.
- Improving Gut Health: Soluble fiber is linked to improved gut health — which is linked to better weight management.
Glucomannan, a soluble fiber, is the main ingredient in Lipozene and may increase feelings of fullness — leading to less intake of calories. Soluble fiber is also linked to better weight management by improving gut health.
However, results are mixed on whether glucomannan — the main ingredient in Lipozene — can improve weight loss specifically.
The creators of Lipozene sponsored their own 8-week study where participants were instructed to take glucomannan and not change anything in their diet or exercise regimen.
They reported an average loss of 4.93 pounds, and that 78% of the weight loss was from loss of body fat — although it is unclear how this was measured.
It is important to note this information came directly from their website, and there was no link to an actual study. However, recent research has shown positive effects on weight loss with glucomannan.
Studies on Glucomannan
One analysis involving 225 people found that glucomannan supplementation can lead to a significant reduction in body weight in those who are obese or overweight. (5)
In another review of overweight children and adults, the effects of glucomannan on body weight and body mass index (BMI) were analyzed. (6)
The data on children in this review was too limited to conclude a positive effect of glucomannan on weight loss. But, a short-term intake of glucomannan showed a positive effect on reducing body weight in 3 of 5 studies on adults. (6)
However, other studies have shown no effect on weight loss with glucomannan.
These included a recent study on 96 overweight and obese children ages 6–17 years who supplemented with glucomannan for 12 weeks, and a 2014 study involving 9 randomized clinical trials with adults. (7)
Results showed glucomannan did not significantly improve weight loss. (8)
In addition, A 2013 study involving overweight or obese people taking glucomannan found that although it was considered safe, it did not promote weight loss or significantly alter body composition or hunger and fullness levels. (9)
Although recent evidence has been favorable in support of glucomannan for short-term weight loss, some older studies have shown no improvements.
Also, reviews on the Lipozene website are mixed. Some reviewers claim it works well, while others claim it has not helped them with weight loss at all.
Improving fiber intake may be helpful for weight loss, and recent, high-quality clinical evidence has been favorable in support of glucomannan for short-term weight loss in adults. However, older studies and reviews of the formulation of Lipozene and its proprietary blend remain mixed.
When it comes to the claims of weight loss by the makers of Lipozene, there has been some controversy.
The company behind Lipozene, Obesity Research Institute, was involved in a class action settlement and accused of deceiving consumers about the effectiveness of its supplment. The complaint was filed in 2013.
Although the company did not admit to any wrong-doing, it settled for $4.6 million to end the lawsuit in 2019.
Lipozene is non-GMO, gluten-free, and caffeine-free.
When purchasing supplements, you may also want to consider the inactive ingredients listed. Lipozene contains the following inactive ingredients:
- Gelatin: Adds bulk to the product.
- Microcrystalline Cellulose, Magnesium Silicate & Stearic Acid: Food additives that act as anti-caking agents and fillers.
- Titanium Dioxide: A food coloring agent.
- FD&C Blue #1: An artificial blue dye.
These ingredients play no role in weight loss but are added for color and as fillers for bulking and anti-caking — to decrease glucomannan from clumping in the capsule.
Because gelatin is derived from animal products, Lipozene is not suitable for vegetarians or vegans.
The main ingredient in Lipozene — glucomannan — is generally considered safe. Since it is a fiber supplement, the primary side effects are related to potential gastrointestinal discomfort.
According to the National Institutes of Health (NIH), the main side effects of glucomannan include belching, bloating, loose stools, flatulence, diarrhea, constipation, and abdominal discomfort. (10)
Glucomannan also has the potential ability to lower blood sugar, which may benefit some people.
However, those receiving insulin or drugs for blood sugar management should speak with their doctor before using this product.
Glucomannan may also reduce the absorption of other oral medications, so it is advised to take these medications either 1 hour before — or 4 hours after — taking glucomannan. (11)
People with structural abnormalities of the esophagus or gut should avoid glucomannan as it could cause a blockage. However, this is very rare. (11)
The other ingredients in the supplement are also generally considered safe, but there is controversy about some of these ingredients.
For example, titanium dioxide is not considered safe by the European Food Safety Authority (EFSA), even though it is approved by the U.S. Food and Drug Administration (FDA).
Food dyes have been linked to various health issues like ADHD, depression, and even cancer. (12)
In addition, there are some concerns about the safety of gelatin, and large amounts should be avoided. However, gelatin is considered likely safe for most people in small amounts. (13)
Microcrystalline cellulose, magnesium silicate, and stearic acid are generally recognized as safe to consume. However, too much microcrystalline cellulose can cause gastrointestinal side effects similar to glucomannan.
A dose of Lipozene is 2 capsules, taken up to three times per day (maximum of 6 capsules daily).
The manufacturer recommends taking each dose 30 minutes before three of your largest meals.
Taking these with at least 8 ounces (250 ml) of water is important, and the company does not recommend taking more than the 6 capsules per day.
Each Lipozene capsule contains 0.75 grams of glucomannan, so taking 2 capsules provides 1.5 grams of glucomannan.
If you take 6 Lipozene capsules per day, this is equivalent to taking 4.5 grams of glucomannan.
The safe or effective dose of glucomannan has not been fully established. Research shows a very wide range of dosing. Anywhere from 1.2–15.1 grams per day may be beneficial. (10)
The manufacturer offers a buy-one-get-one-free bottle when you purchase directly from their website. Two bottles of 30 capsules each (60 capsules total) is $29.95, which includes free shipping and handling.
Thus a one-month supply would cost roughly $90 if taking the recommended dose of 2 capsules, three times per day.
Lipozene offers a 30-day money-back guarantee, minus a $1.35 processing fee.
This product can be purchased at a lower cost from Amazon, Walmart, Target, or CVS. For example, you can buy a 120-count bottle of Lipozene on Amazon or at Walmart for $32.95.
However, the money-back guarantee is only good for products purchased directly from the Lipozene website or TV ads.
A wide variety of glucomannan supplements are available at most stores and online retailers for a fraction of the cost of Lipozene.
NOW Foods offers 180 capsules for $21.99. This would be a month’s supply if taking 2 capsules, three times per day.
You may also consider Nature’s Way Glucomannan Root, a natural supplement that costs only $19.49 for 100 capsules. With a recommended dosage of 2–3 capsules per day, the bottle should last 4–6 weeks.
Another low-cost glucomannan supplement is NutriGold Glucomannan GOLD. A bottle containing 120 pills is $21.98, and the recommended dosage is 2 capsules up to three times per day.
Overall, Lipozene is significantly more expensive than other brands with the same ingredient. If opting to purchase a glucomannan supplement, the same potential benefits can be seen from a less expensive option.
Quick Comparison Table
|Lipozene||NOW Foods Glucomannan||Nature’s Way Glucomannan Root||NutriGold Glucomannan GOLD|
|Regular Price for 30-day Supply||$90||$21.99||$19.49||$21.98|
|Discounted or Subscription Price||
Trial package of buy one, get one free for $29.95, Mega Bottle includes 120 capsules for $32.95
|None||None||The website has a 20% discount multiple times a year|
Free shipping over $50, other $6.95 for standard shipping
Free shipping over $25, otherwise $4.9 for standard shipping
Free shipping over $49, otherwise $4.99 for standard shipping
|Returns||30-day money-back guarantee (minus a $1.35 processing fee)||30-day return on new, unopened items||45-day money-back guarantee (minus shipping)||60-day money-back guarantee (minus shipping)|
|Key Ingredients Per Serving||1500 mg proprietary blend from konjac root||1725 mg glucomannan from konjac root||1995 mg glucomannan from konjac root||1400 mg glucomannan from konjac root|
|Main Benefits||Weight loss||
Weight loss, Cholesterol management, Intestinal regularity
|Promotes feelings of fullness||
Supports digestive, heart, glucose, and gut health
Done by the manufacturer and not verified
Frequently Asked Questions
What is the main ingredient in Lipozene?
The proprietary blend used in Lipozene is from the root of the konjac plant, Amorphophallus konjac, also called elephant yam. This contains a water-soluble fiber called glucomannan.
Does Lipozene work?
Newer RCTs on adults have shown a positive effect of glucomannan on weight loss. However, results of older studies are mixed and Lipozene itself, with its proprietary blend, has mixed reviews.
How much weight can one expect to lose if they take Lipozene?
Results vary based on the individual. The company offers a money-back guarantee if the product does not work.
Is Lipozene safe?
The main ingredient in Lipozene, glucomannan, is generally considered safe.
Does Lipozene have side effects?
Glucomannan may cause gastrointestinal discomfort in some people. It is not recommended for patients with structural abnormalities of the esophagus or gut as it could increase the risk of esophageal and gastric obstruction. It is best to speak with your doctor if you have blood sugar issues and are on medications as it could cause low blood sugar.
Is Lipozene cost effective?
Compared to other products with glucomannan, Lipozene is much more expensive at a cost of about $90 a month if taking the recommended dose of 2 pills, 3 times per day.
Is Lipozene a good product for weight loss?
For most people, this supplement is safe and may have some benefits. Overall, as a dietitian, I recommend making fiber intake through your daily diet a priority over a supplement to improve weight loss.
Overall, taking Lipozene is likely safe as it contains glucomannan — a soluble fiber supplement.
Some potential side effects are those involving gastrointestinal discomfort.
Recent high-quality research on glucomannan for weight loss in adults has been favorable. However, older high-quality studies have not shown this same positive impact.
Current reviews of Lipozene itself, with its proprietary blend, are mixed. In addition, the company making Lipozene has had legal action taken against them, alleging false claims of weight loss.
While there is no harm in taking Lipozene, as a dietitian, I generally recommend getting enough fiber through your diet and not having a focus on fiber supplements — including those touted for weight loss.
However, supplementing fiber, such as Lipozene, in addition to getting adequate amounts in your diet may be helpful.
Overall, your diet and lifestyle will have the biggest impact on your weight and health over a supplement.
At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.
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- Can dietary viscous fiber affect body weight independently of an energy-restrictive diet? A systematic review and meta-analysis of randomized controlled trials - PubMed:
- Konjac Glucomannan, a Promising Polysaccharide of Amorphophallus konjac K. Koch in Health Care: – ResearchGate:
- Glucomannan: Health Benefits, Side Effects, Uses, Dose & Precautions:
- Effects of glucomannan supplementation on weight loss in overweight and obese adults: A systematic review and meta-analysis of randomized controlled trials – ScienceDirect:
- The effect of glucomannan on body weight in overweight or obese children and adults: A systematic review of randomized controlled trials – ScienceDirect:
- No Effect of Glucomannan on Body Weight Reduction in Children and Adolescents with Overweight and Obesity: A Randomized Controlled Trial - PubMed:
- The Efficacy of Glucomannan Supplementation in Overweight and Obesity: A Systematic Review and Meta-Analysis of Randomized Clinical Trials – Taylor & Francis Online:
- Safety and Efficacy of Glucomannan for Weight Loss in Overweight and Moderately Obese Adults - PMC:
- Dietary Supplements for Weight Loss - Health Professional Fact Sheet:
- Glucomannan – Drugs.com:
- Is Food Coloring Safe for Kids? – Cleveland Clinic:
- How safe is gelatin? A systematic review and meta-analysis of gelatin-containing plasma expanders vs crystalloids and albumin - PubMed: