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Lipozene Review: Does It Work for Weight Loss? Our Dietitian Explains

Written by Emily Hirsch, MS, RD

Reviewed by Anthony Dugarte, MD 

Last Updated on June 2, 2021

Our Expert Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:2.7
  • Ingredient Safety:4.0
  • Value for the Price:1.0
  • Brand Transparency:2.0

In a sea of weight loss supplements, Lipozene joins the ranks claiming to decrease your calorie intake, thus helping you lose weight naturally. Although we all want the secret to effortless weight loss, when evaluated scientifically, the ingredients in Lipozene fall flat.

Lipozene Review: Does It Work for Weight Loss? Our Dietitian Explains


  • Can potentially decrease appetite and reduce overeating due to the increased fiber intake
  • Has the potential to promote gut health


  • Lacking in independent, sound research
  • Potential for unpleasant side effects
  • Expensive compared to other glucomannan supplements

What Is Lipozene?

Lipozene is a weight loss supplement promising to help people lose weight without changing anything about their eating habits or lifestyle.

The only active ingredient in Lipozene is glucomannan.

Glucomannan is a natural, water-soluble dietary fiber obtained from the roots of the elephant yam, also known as konjac.

The glucomannan fiber is extremely viscous and has an amazing ability to absorb water. A single capsule can turn a full glass of water into a gel.

When ingested with water, glucomannan creates a thick, gel-like substance in the stomach, helping people feel fuller faster.

Lipozene is manufactured by the Obesity Research Institute, a California-based company founded in 2003. The Obesity Research Institute has created various products within the weight loss space.

How Could Lipozene Promote Weight Loss?

Based on many research studies, fiber intake is linked to lower body weight.

Considering the high-fiber nature of glucomannan, Lipozene may promote weight loss in the following ways:

Keeps You Feeling Fuller for Longer

Due to its water-absorbing properties, glucomannan will attract water and expand in the stomach.

This process will slow the rate of digestion, helping the stomach to feel fuller, so you eat less.

Reduces Dietary Calorie Intake

Glucomannan may decrease the absorption of other calorie-containing nutrients, like protein and fat.

This would potentially mean absorbing fewer calories from the food you eat.

May Promote Gut Health

Increasing fiber intake promotes good bacteria in the gut. Enhancing the gut microbiome may lead to weight loss.

According to a recent review of the research, changing the gut microbiome may be an important tool in the treatment of obesity and lead to reductions in BMI, body weight, and fat mass.

Does Lipozene Actually Work?

Lipozene promises that you will lose weight and body fat. The Lipozene website claims to have completed clinical studies using the product with great success.

The site states that “Overweight persons in the active group and all persons in the first study lost on average at least 4.93 more pounds than placebo.”

Additionally, the study claims that 78% of each pound lost was pure body fat.

Unfortunately, as remarkable as these numbers may sound, the study is limited in several ways.

There is no information on how body fat was measured, no information on the calorie intake or exercise regimen in either group, and the study was never peer-reviewed.

Peer-reviewed studies meet certain standards of scientific quality and are considered a trusted form of scientific communication.

A peer-reviewed study from the Journal of Obesity found that Glucomannan supplements administered over 8 weeks did not promote weight loss or significantly alter body composition or hunger and fullness.

Another study concluded that glucomannan did promote limited weight loss but researchers found no change in long-term body mass index (BMI).

Moreover, according to the National Institutes of Health (NIH), glucomannan has “little to no effect on body weight.”

Verdict on Claimed Benefits

Below is our summary of the available evidence for the claimed benefits of Lipozene based on the available research:

  • Helps reduce weightModerate Evidence
  • Helps reduce body fatLimited Evidence
  • Safe and effectiveModerate Evidence

Side Effects and Dosage

According to the National Institutes of Health (NIH), the side effects of taking glucomannan may include loose stools, gas, diarrhea, constipation, and abdominal discomfort.

Since it is just a fiber supplement, there is little concern for side effects beyond gastrointestinal problems.

Lipozene recommends taking 2 pills 30 minutes before each meal, for a recommended maximum dose of 6 pills per day.

Each Lipozene pill contains 0.75 grams of glucomannan, so taking 2 pills would provide 1.5 grams of glucomannan.

The recommended dosage is the equivalent of taking 4.5 grams of glucomannan a day, which exceeds the amount known to be effective for weight loss

Every serving of Lipozene should be accompanied by at least 8 ounces of water.

It is important to talk to your healthcare provider before taking Lipozene or any other supplement to ensure its safety for you.


Your cost of Lipozene will depend on how much is taken. When purchased directly from the manufacturer, a bottle of Lipozene is $29.95, which includes free shipping and handling.

Based on Lipozene’s recommended dosage (2 capsules, 3 times per day), a one-month supply would cost roughly $90. Lipozene does offer a money-back guarantee.

Comparison to Alternatives

Ninety dollars per month is very steep compared to other supplements with a similar active ingredient.

Glucomannan supplements are available at most stores and online retailers for a fraction of the cost of Lipozene.

For example, NOW Foods offers a glucomannan supplement for $8.39 for a month’s supply.

There are a wide variety of glucomannan supplements on the market to choose from.

Nature’s Way Glucomannan Root is a natural supplement that costs only $14.66 for 100 capsules. With a recommended dosage of 2–3 capsules per day, the bottle should last 4–6 weeks.

NutriGold Glucomannan GOLD is another low-cost glucomannan supplement. A bottle containing 120 pills is $16.49, and the recommended dosage is 2 capsules per day. The bottle should last roughly 2 months.

The Bottom Line

Imagine taking a few pills, and suddenly the stubborn fat on your body melts away?

If you were to apply common sense to this question, then there wouldn’t be anyone seeking weight loss solutions – a miracle pill would have met their weight loss goals.

Unfortunately, Lipozene is not that miracle pill many people are longing for.

While there may be some science that supports short-term weight loss resulting from taking this supplement, there have been no actual scientific studies on Lipozene itself.

Additionally, no dietary supplement can replace other healthy weight loss habits.

A Word from Our RD

Any company that claims their product will help you lose weight without dietary or lifestyle changes should be met with a great deal of skepticism.

Even though you won’t see immediate results, eating a healthy, well-balanced diet, reducing calorie intake, and participating in regular physical activity is a tried and true way to help with weight management.

Until that miracle pill is developed, we’re all at the mercy of a healthy lifestyle to reach our weight goals.

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