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ProstaGenix Review: A Detailed Look at Ingredients, Side Effects, Cost, and More

Written by Lauren Panoff, MPH, RD

Reviewed by Anthony Dugarte, MD 

Last Updated on April 14, 2021

Our Expert Rating:

3.3

About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:2.3
  • Ingredient Safety:4.0
  • Value for the Price:3.0
  • Brand Transparency:4.0

ProstaGenix is a supplement formulated to alleviate common prostate problems in adult men, such as nighttime urination, urgency, and better bladder emptying. While the product makes several strong claims, most of its ingredients lack much robust evidence with the exception of beta-sitosterol.

ProstaGenix Review: A Detailed Look at Ingredients, Side Effects, Cost, and More

Pros

  • Offers a solid 90-day money back guarantee with a direct number to call.
  • A few of the ingredients have potential promise for prostate symptom management.

Cons

  • Product has no third-party testing certification.
  • Many of the ingredients lack robust human evidence behind their uses in prostate health.
  • More expensive than many other prostate health products.

Background

ProstaGenix claims to be the first and only prostate supplement that contains more than 1,000 mg of mixed sterols to support prostate health.

The first thing I noticed when visiting the ProstaGenix website is that they have paid Larry King to be their celebrity spokesperson.

I also see flashy claims and several grammatical errors on the site. In all fairness, these are mostly just obnoxious to read and may not accurately reflect the product itself.

As a registered dietitian, my biggest red flags are that finding the ingredients list and supplement facts panel takes some digging (which I eventually found after clicking to the sales page) and that there are no scientific resources offered to back up its claims of “proven science” and effectiveness.

Prostate Health in Aging Men

Male prostate issues are not uncommon with age. Prostate cancer is the leading cancer-related cause of death in men.

One common condition is benign prostatic hyperplasia (BPH), or enlarged prostate, which can cause urinary discomfort, reduce urine flow, and increase the risk for urinary tract or kidney issues.

BPH can raise levels of prostate-specific antigen (PSA), a protein produced by prostate gland cells that may indicate prostate cancer or urinary issues.

Evaluation of Ingredients

ProstaGenix spotlights Beta-sitosterol as its primary active ingredient while rounding the formulation out with a polyphenol blend as well as 11 vitamins and minerals mixture.

I examined the prostate health evidence behind most of the ingredients in its formulation.

Vitamin D3

The role of vitamin D and prostate health, specifically prostate cancer, appears controversial with mixed outcomes.

A 2019 meta-analysis concluded that high-dose vitamin D supplements do not appear beneficial for men with prostate cancer and should not be recommended.

A 2020 study found that while there was no association between serum vitamin D levels and prostate cancer, men with prostate cancer who are also vitamin D deficient may be at higher risk for mortality.

Iodine

I couldn’t find much research on the correlation between iodine and prostate health.

However, the authors of a 2007 study concluded that more research should be done on how having thyroid disease may increase the risk of prostate cancer.

They also said the role of iodine remains speculative.

Zinc

Zinc is a micronutrient known to play a role in normal immune function.

A large concentration of zinc can be found in the human prostate, but research is mixed with the link between zinc and prostate cancer.

A 2003 study noted that chronic zinc oversupply may contribute to prostate cancer development.

However, more recent research suggests that zinc transporters could play a role in prostate tumor suppression.

Selenium

A 2019 clinical trial supplemented 481 men with 200 mcg/day of selenium for six months and measured prostate-specific antigen (PSA) and selenium levels before and after supplementation.

The authors found that selenium changes were highly dependent on baseline selenium levels, and selenium supplementation didn’t affect PSA levels.

However, there was an inverse correlation between PSA changes and selenium changes among men who were younger, never-smokers, who consumed more than the RDI for zinc, and below the RDI for vitamin B12.

Copper, Manganese, Chromium, Molybdenum

While these trace elements are in the ProstaGenix formulation, research was hard to find on their relation to prostate health directly.

Some studies suggest that manganese supplementation may prevent the viability of prostate cancer cells, while some indicate that chromium (VI) may promote prostate tumor progression.

Apparently, elevated levels of copper in the blood have been found in prostate cancer patients.

Beta-Sitosterol

This compound is found in plants and is commonly used to lower cholesterol and improve symptoms of an enlarged prostate.

It works by inhibiting how much cholesterol can enter the body and bind to the prostate to reduce inflammation.

Beta-sitosterol does appear to have evidence for improving enlarged prostate symptoms, but it doesn’t appear to reduce prostate size.

Efficacy also doesn’t seem to improve when combined with other ingredients.

However, a 1999 study does conclude that it improves urine symptoms and increases urinary flow in BPH.

Grape Seed Extract, Pomegranate Seed Extract, and Quercetin

These ingredients do seem to have some evidence in support of their anti-prostate cancer uses, although the efficacy of them as part of this mixture is uncertain, and most research has been done on animals in labs.

Some research indicates that quercetin has anti-cancer effects and may have uses in prostate chemoprevention.

Pomegranate extract is rich in antioxidants. It has been shown to inhibit the growth of prostate cancer cells and trigger cell death in vitro but did not have a significant effect on prostate cancer outcomes in a large placebo-controlled trial.

Grape Seed extract has been observed to have in vivo anticancer efficacy against certain prostate cancers using animal models.

Verdict on Claimed Benefits

Below is our summary of the available evidence for the claimed benefits of ProstaGenix based on the available research:

  • Reduces nighttime urinationModerate Evidence
  • Reduces urgencyModerate Evidence
  • Improves bladder emptyingNo Evidence

Side Effects, Safety, and Dosage

ProstaGenix is to be taken as a single capsule three times per day. Consumers are instructed to take them at any time of day, either on an empty or full stomach.

Each bottle contains 90 capsules – a one-month supply.

The brand indicates that most men experience benefits within the first 10 days of use and more consistently after 3–4 weeks of daily supplementation.

The brand also notes that each ProstaGenix dose contains 852 mg of Beta-sitosterol.

While no standardized dose appears to exist, an older Cochrane review notes that randomized controlled trials on BPH between 1966 and 1998 used Beta-sitosterol dosages of 60 to 195 mg/day with some success for urinary symptoms.

It’s unclear why ProstaGenix uses significantly higher amounts.

Note that Beta-sitosterol products like this shouldn’t be used by men with sitosterolemia, a rare inherited disorder where too much Beta-sitosterol and related fats are stored in the body.

Through my own search, I found that Beta-sitosterol is low-risk for side effects but may cause mild digestive issues in some people and rarely may contribute to erectile dysfunction.

These appear to be among the most commonly reported side effects of similar prostate health nutraceuticals, which may be advantageous for consumers seeking them, as medical treatment of BPH is not risk-free itself.

That being said, BPH symptoms may be caused by a number of things that could be more serious.

It’s best to speak to your doctor before taking a supplement for prostate health, especially if urinary symptoms are present. 

Furthermore, while the product claims to be tested for quality and purity at a third-party laboratory, ProstaGenix does not bear an official third-party testing mark that would hold much more credibility.

The bottle does say at the top “Verified Nutrition Laboratory Tested,” which certainly doesn’t indicate any major independent testing organizations and makes no sense to me.

ProstaGenix highlights that it received an award for being the #1 rated prostate supplement in 2017 by the National Health Federation.

While the website says NHF is “the oldest non-profit health organization,” it fails to state that the NHF is a lobbying group that promotes dietary supplements and alternative medicine while opposing evidence-based public health efforts like childhood vaccinations and fluoridated water.

NHF-promoted products are opposed by professional organizations such as the American Cancer Society.

Cost and Where to Buy

ProstaGenix can be purchased on its website as:

  • Single bottle for $49.95
  • 3-pack for $99.95
  • 5-pack for $149.95

The company offers a 90-day money-back guarantee, in which you can get a full refund minus shipping and handling fees if you’re not satisfied.

You can also find ProstaGenix via a quick search on Amazon, where the price varies.

The price for a 3-pack is the same, but you can get one bottle for cheaper on Amazon, whereas a 5-pack is at least $10 more than the brand website.

How It Compares

Many prostate health supplements contain Beta-sitosterol, which makes sense as this seems to have the most relevant evidence.

Compared to other products, ProstaGenix appears to have more ingredients and cost more.

Many other prostate products contain saw palmetto and lycopene, which ProstaGenix says are “worthless gimmicks.”

I don’t know that I’d word it quite like that, but it does appear to be true that evidence is lacking for saw palmetto or lycopene on their own for efficacy in treating urinary symptoms of BPH.

Studies on lycopene suggest more research is needed, as there’s not enough evidence to refute its potential in this area.

A 2012 Cochrane review found that even large doses of saw palmetto alone had no effect on urine flow or prostate size. However, other studies on these two ingredients used together show some potential.

For instance, a 2018 clinical trial of 400 men found that a combination of saw palmetto, selenium, and lycopene was as effective as the commonly prescribed BPH medication tadalafil in improving lower urinary tract symptoms.

A 2014 study also found success with a combination of saw palmetto, lycopene, and selenium plus tamsulosin in improving BPH urine flow rate compared to individual therapies.

The Bottom Line

ProstaGenix is marketed as the best, most evidence-based prostate health supplement on the market.

However, while there is evidence for the use of Beta-sitosterol to reduce symptoms of common prostate complaints in men with BPH, I’m not sold on the necessity of many other ingredients in their formulation.

While it’s certainly possible it could help alleviate BPH symptoms, this product comes across to me as a lot of loud claims without convincing support for most of its formulation.

Men with prostate complaints should speak to their physician for appropriate evaluation and treatment recommendations before buying this product.

A Word from Our RD

Like many supplements, this product is attractive for men seeking an alternative approach for managing urinary symptoms of BPH.

While it seems likely that the biggest risks of using this product are that it doesn’t work and causes mild digestive side effects, I would recommend looking at overall dietary patterns first.

Research on BPH and nutrition indicates mixed results for supplemental beta-sitosterol, whereas reducing alcohol and dairy consumption, and eating more polyunsaturated fats and vegetables, are more promising for alleviating lower urinary symptoms.

A whole-diet approach is more likely to improve other aspects of life and BPH symptoms, which is a better investment, in my opinion.

As with all nutraceuticals, it’s best to speak with your doctor before self-medicating with this product to make sure it’s appropriate and that all symptoms have been properly evaluated.

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