Pruvit Keto OS Nat Review: An Unnecessary and Expensive Supplement
Medically Reviewed by Anthony Dugarte, MD
Last Updated on February 22, 2023
While transitioning into keto can be uncomfortable, the keto flu symptoms usually go away within a week. So there may not be a reason to introduce a potentially unsafe supplement, like Pruvit, to help with this short transitional period.
- Pruvit’s exogenous ketone product Keto//OS Nat is designed to increase your energy, focus, and fat loss by putting you artificially into a state of ketosis or fat burning.
- Exogenous ketones may help you get into ketosis faster, but if you don’t change your diet, these results will not be sustained.
- Pruvit Keto//OS NAT has significant safety concerns, particularly for people at risk of high blood pressure.
- This supplement is expensive.
- Overall, we would not recommend this product to help you “hack” your way into ketosis.
What We Liked
- May help ease some of the symptoms of “keto flu”
- Contains antioxidants that may be beneficial to overall health
- Contains high levels of minerals, which could lead to imbalances and high blood pressure
- Limited evidence to support the benefits of using ketone salts
Before evaluating what Pruvit ketosis supplement offers, we must understand the basics of ketosis and ketones. Your body relies upon food’s two primary energy sources, fat and carbohydrates. Carbohydrates are broken down into glucose and used for energy.
Fat is metabolized into ketone bodies and used for energy. (1)
While the body prefers to fuel itself with carbohydrates, sometimes it runs out of this energy source and turns to fat instead.
Burning fat for energy is called ketogenesis. This can happen while you are sleeping at night or after a tough cardio session when your body runs out of stored carbs.
Once you eat carbs, your body switches back to burning carbs instead. But there is a potential benefit to staying in fat-burning mode all the time.
Your body contains almost unlimited calories from stored fat, and many of us carry around a bit too much body fat.
If you are able to maintain the state of ketogenesis, called ketosis, you begin to burn fat, your hunger decreases, and you have more energy.
This process of switching your metabolism into “fat-burning” mode is the underlying reasoning behind the popular ketogenic diet, a deficient carb diet designed to help you achieve ketosis or become a “fat burner” for weight loss and improved energy. (2)
You can only maintain the state of ketosis if carbohydrates are not present. Since the body preferentially likes to burn carbs, you will no longer remain in ketosis as soon as you eat a carb.
This is where Pruvit Ketones supplement comes in, offering a “shortcut” to achieving ketosis.
Pruvit Keto//OS Nat is an exogenous (from outside the body) ketone product that contains ketone salts, amino acids, B vitamins, and a branded version of Cat’s Claw designed to help your body artificially get into ketosis.
Pruvit claims that taking this product twice a day will help you lose body fat and have a ton of energy.
There are two versions of the product – Charged and Caffeine Free. There is no difference between them other than the caffeine content. The Charged version contains the equivalent of 12–16 oz of coffee, but the exact amount is not specified.
The recommended dosage for Pruvit Keto//OS NAT is 2 packets a day. You take the caffeinated version called Charged before 9 am and the Caffeine Free before 7 pm.
Drinking half your body weight in water daily is also recommended to help flush out the minerals in the product.
Pruvit Ketone supplements are costly at $130 for 20 servings when purchased from the Pruvit website. If you have to take two pills daily, you will spend over $260 for a 20-day supply.
You can save around $30 if you subscribe to a monthly shipment, but this doesn’t apply to the first month.
While some research exists on the potential benefit of exogenous ketones, it is mainly limited to animal studies. Overall, It is unlikely this product will benefit you greatly if you continue to eat carbs while taking it.
The active ingredient is a blend called N8 Max NAT (12.6 mg). The exact amount of each ingredient of the blend is not listed.
This blend contains:
- Keto salt (R-beta Hydroxybutyrate): At this time, there is little evidence to support the benefits of ketone supplements for humans above what can be achieved by simply following a keto diet. (3)
- Amino acids L-taurine and fermented L-leucine: While these amino acids are important for overall health and exercise performance, most people get more than enough from food.
- C-Med 100 (Inner bark of Uncaria Tomentosa): There is limited evidence in humans on Cat’s Claw potential beneficial effects.
Expand Below to See the Detailed Research
R-Beta Hydroxybutyrate (BHB)
The active ingredient in Pruvit's Ketone supplement is the ketone salt called BHB.
Ketone salts are ketones that are bound to mineral salts or amino acids that can be dissolved in water. (4)
It is the reason why the calcium, magnesium, and sodium content of the product are so high. The BHB is bound to these minerals.
Taking exogenous ketones may help reduce the symptoms experienced when transitioning to the keto diet, sometimes called the “keto flu.” (5)
Pruvit Ketosis Supplements help you stick with your keto diet, so you achieve ketosis faster.
If you took 2 doses of the product per day, as recommended, that would account for 80% of your daily sodium needs.
With most people already far exceeding sodium needs on a daily basis, this is a major concern for people with elevated blood pressure and could lead to dehydration or electrolyte imbalance. (6)
There is limited evidence of the benefits of exogenous ketones in humans.
While human studies have found that taking oral ketones can increase blood ketone levels, it is unclear if there is a benefit beyond that.
As far as the claims made by Pruvit of increased energy or fat loss, there is little evidence.
A 2020 systematic review found conflicting evidence over the benefit of taking ketone salts to improve physical performance. (7)
It is also unclear if taking ketone salts without following a ketogenic diet will result in fat loss.
A small 2017 study found that a ketone beverage did reduce ghrelin (a hunger hormone) and appetite. But it is not clear if this would result in sustained weight loss. (8)
The amino acids taurine and leucine are also included in the product, but the amount is unknown.
Taurine is a conditionally essential amino acid, meaning your body needs more of it during times of increased stress or illness. (9)
Leucine is an essential amino acid and one of the three branched chain amino acids.
It plays a role in building muscle, regulating human growth hormone, and may help reduce body fat. (12)
C-Med 100 (Inner Bark of Uncaria Tomentosa)
C-Med 100 is a branded version of a vine more commonly known as Cat’s Claw.
It may help reduce inflammation, support immune function, and repair DNA. (13)
Cat’s Claw is a rich source of antioxidants that may be beneficial to overall health.
- 45 calories
- 5 grams of carbohydrates
- 4 grams of sugar alcohols
- 5 mg vitamin B6 (294% daily value)
- 100 mcg vitamin B12 (4167% daily value)
- 240 mg calcium (18% daily value)
- 235 mg magnesium (56% daily value)
- 910 mg sodium (40% daily value)
As mentioned earlier, the mineral content of ketone salts is extremely high. If you took 2 packets daily, you would consume 80% of your daily sodium needs.
The average sodium intake for most people is already around 3,400 mg per day, which is significantly beyond the recommended 2,300 mg. (14)
If you didn’t change anything else in your diet, this product could put you at significant risk of high blood pressure, kidney damage, or electrolyte imbalances.
Exogenous ketones may cause stomach discomforts such as diarrhea, nausea, or gas. (15)
The diuretic effect of the product might also give you symptoms of mild dehydration, like headache and fatigue.
The caffeine content is also a concern. While the product likely does not contain excessive caffeine, consuming more than 400 mg per day can lead to anxiety or an increased heart rate. (16)
When taking Pruvit, remember to factor in how much caffeine you’re consuming from other sources daily, not to exceed the daily limit.
Always speak to your doctor before taking any dietary supplements or starting a ketogenic diet.
A product that may help with the transition into ketosis by maintaining energy levels and reducing the side effects of the keto diet is MCT oil.
MCTs are a type of oil that do not act like other fats but are readily used for energy by the body.
MCTs have fewer side effects than ketone salts and do not pose a danger to blood pressure.
Many keto-product brands carry pure MCT oil to be used as a dietary supplement.
If you are struggling with the “keto flu,” drink plenty of water, cut back on intense exercise, get lots of rest, eat enough fat, and consider adding more salt to your food for a few days.
The symptoms of fatigue should pass quickly as your body adjusts. While I am not opposed to the keto diet short-term for weight loss or other potential health benefits, it is not sustainable long-term. It may also increase blood cholesterol in some people.
If your goal is weight loss or improved energy, a diet full of fruits, vegetables, and lean protein is the healthiest and most sustainable without cutting out all the foods you love.
At WellnessVerge, we only use reputable sources, including peer-reviewed medical journals and well-respected academic institutions.
- Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry:
- Ketogenic Diet for Obesity: Friend or Foe?:
- Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments:
- Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?:
- On the Metabolism of Exogenous Ketones in Humans:
- CDC: Sodium:
- Utility of Ketone Supplementation to Enhance Physical Performance: A Systematic Review:
- A Ketone Ester Drink Lowers Human Ghrelin and Appetite:
- Review: taurine: a "very essential" amino acid:
- Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men:
- The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists:
- Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis:
- Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content:
- 2015-2020 Dietary Guidelines:
- Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects:
- Effects of caffeine on human behavior: