Pruvit Keto OS Nat Review: A Dietitian Evaluates Its Claims
Pruvit’s exogenous ketone product Keto//OS Nat is meant to increase your energy, focus, and fat loss by putting you artificially into a state of ketosis or fat burning. This is a potentially dangerous product with limited evidence to support its benefits.
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Pruvit Keto//OS Nat is an exogenous ketone product that contains ketone salts, amino acids, and a branded version of Cat’s Claw designed to help your body get into ketosis.
First, it’s important to understand a bit about ketosis and ketones.
Your body relies upon two primary sources of energy, either fat or carbohydrates from food.
Carbohydrates are broken down into glucose and used for energy.
Fat is metabolized into ketone bodies and used for energy.
While the body prefers to fuel itself with carbohydrates, sometimes it runs out of this energy source and turns to fat instead.
Burning fat for energy is called ketogenesis. This can happen while you are sleeping at night or after a tough cardio session when your body runs out of stored carbs.
Once you eat carbs, your body switches back to burning carbs instead.
But there is a potential benefit to staying in fat-burning mode all the time.
Your body contains an almost unlimited number of calories from stored fat and many of us are carrying around a bit too much body fat.
If you are able to maintain the state of ketogenesis, called ketosis, you begin to burn fat, your hunger decreases, and you have more energy.
This process of switching your metabolism into “fat burning” mode is the underlying reasoning behind the popular ketogenic “keto” diet, a very low carb diet designed to help you achieve ketosis or become a “fat burner” for weight loss and improved energy.
You can only maintain the state of ketosis if carbohydrates are not present. Since the body preferentially likes to burn carbs, as soon as you eat a carb you will no longer remain in ketosis.
Pruvit's Ketones supplement is a “short cut” to achieving ketosis.
It contains exogenous ketones or ketones from outside the body.
Its primary ingredient is a blend of a ketone called beta-hydroxybutyrate, B-vitamins, amino acids, and a branded version of Cat’s Claw to help put the body artificially into ketosis.
Pruvit claims that taking this product twice a day will help you lose body fat and have a ton of energy.
It is unlikely this product will have much benefit if you continue to eat carbs in addition to taking the product.
While some research exists on the potential benefit of exogenous ketones, it is limited mostly to animal studies.
One packet of Pruvit Keto//OS Nat contains:
- 45 calories
- 5 grams of carbohydrates
- 4 grams of sugar alcohols
- 5 mg vitamin B6 (294% daily value)
- 100 mcg vitamin B12 (4167% daily value)
- 240 mg calcium (18% daily value)
- 235 mg magnesium (56% daily value)
- 910 mg sodium (40% daily value)
The active ingredient is a blend called N8 Max NAT (12.6 mg).
This blend contains a keto salt (R-beta Hydroxybutyrate), L-taurine, fermented L-leucine, and C-Med 100 (Inner bark of Uncaria Tomentosa).
The exact composition of the blend is not listed.
There are two versions of the product – Charged and Caffeine Free.
There is no difference between them other than the caffeine content.
Charged contains the equivalent 12–16 oz of coffee, but the exact amount is not specified.
R-Beta Hydroxybutyrate (BHB)
The active ingredient in Pruvit's Ketone supplement is the ketone salt called BHB.
Ketone salts are ketones that are bound to mineral salts or amino acids that can be dissolved in water.
It is the reason why the calcium, magnesium, and sodium content of the product are so high. The BHB is bound to these minerals.
Taking exogenous ketones may help reduce the symptoms experienced when transitioning to the keto diet, sometimes called the “keto flu.”
Pruvit Ketosis Supplements help you stick with your keto diet, so you achieve ketosis faster.
If you took 2 doses of the product per day, as recommended, that would account for 80% of your daily sodium needs.
With most people already far exceeding sodium needs on a daily basis, this is a major concern for people with elevated blood pressure and could lead to dehydration or electrolyte imbalance.
There is limited evidence of the benefits of exogenous ketones in humans.
While human studies have found that taking oral ketones can increase blood ketone levels, it is unclear if there is a benefit beyond that.
As far as the claims made by Pruvit of increased energy or fat loss, there is little evidence.
A 2020 systematic review found conflicting evidence over the benefit of taking ketone salts to improve physical performance.
It is also unclear if taking ketone salts without following a ketogenic diet will result in fat loss.
A small 2017 study found that a ketone beverage did reduce ghrelin (a hunger hormone) and appetite. But it is not clear if this would result in sustained weight loss.
At this time, there is little evidence to support the benefits of ketone supplements for humans above what can be achieved by simply following a keto diet.
The amino acids taurine and leucine are also included in the product, but the amount is unknown.
Taurine is a conditionally essential amino acid, meaning your body needs more of it during times of increased stress or illness.
Leucine is an essential amino acid and one of the three branched chain amino acids.
It plays a role in building muscle, regulating human growth hormone, and may help reduce body fat.
While these amino acids are important for overall health and exercise performance, most people get more than enough from food.
C-Med 100 (Inner Bark of Uncaria Tomentosa)
C-Med 100 is a branded version of a vine more commonly known as Cat’s Claw.
It may help reduce inflammation, support immune function, and repair DNA.
Cat’s Claw is a rich source of antioxidants that may be beneficial to overall health.
There is limited evidence in humans on Cat’s Claw potential beneficial effects.
Below is our summary of the available evidence for the claimed benefits of Pruvit Keto based on the available research:
- Fierce focusModerate Evidence
- Favorable fat lossModerate Evidence
The recommended dosage for Pruvit Keto//OS NAT is 2 packets a day.
You take the caffeinated version called Charged before 9 am and the Caffeine Free before 7 pm.
It is also recommended that you drink half your body weight in water daily to help flush out the minerals in the product.
As mentioned, the mineral content of the ketone salts is extremely high.
If you took 2 packets a day, you would be consuming 80% of your daily sodium needs.
The average sodium intake for most people is already around 3400 mg per day, which is significantly beyond the recommended 2300 mg.
If you didn’t change anything else in your diet, this product could put you at significant risk of high blood pressure, kidney damage, or electrolyte imbalances.
Exogenous ketones may cause stomach discomfort like diarrhea, nausea, or gas.
The diuretic effect of the product might also give you symptoms of mild dehydration, like headache and fatigue.
The caffeine content is also a concern.
While the product itself likely does not contain an excessive amount of caffeine, consuming more than 400 mg per day can lead to anxiety or an increased heart rate.
The dosage in this product should be evaluated against other sources of caffeine you might be taking.
Always speak to your doctor before taking any dietary supplements or starting a ketogenic diet.
Pruvit Ketone supplements are extremely expensive at $130 for 20 servings when purchased from the Pruvit website.
If you have to take 2 per day, this means you would be spending over $260 for a 20-day supply.
You can save around $30 if you subscribe to a monthly shipment, but this doesn’t apply to the first month.
There are many other exogenous ketone products on the market that are significantly cheaper than Pruvit Keto//OS NAT.
Kiss My Keto has a BHB-based exogenous ketone product for $29.99 for a 15-day supply.
Perfect Keto also carries a BHB-based product for $39.99 for a 15-day supply.
These are also all very high in sodium and other minerals, therefore I would proceed with caution around any ketone salt supplements.
Another product that may help with the transition into ketosis by maintaining energy levels and reducing side effects of the keto diet is MCT oil.
MCTs are a type of oil that do not act like other fats, but are readily used for energy by the body.
MCTs have fewer side effects than ketone salts and do not pose a danger to blood pressure.
If I wanted help transitioning to ketosis, I would use MCT oils instead. Many keto-product brands carry pure MCT oil to be used as a dietary supplement.
Exogenous ketones, like Pruvit Keto//OS NAT may help you get into ketosis faster, but if you don’t change your diet these results will not be sustained.
Pruvit Keto//OS NAT also comes with significant side effects, particularly for people at risk of high blood pressure.
This supplement is significantly more expensive than its competitors, therefore I would not recommend this product to help you “hack” your way into ketosis.
The ketogenic diet has many possible benefits for overall health and weight loss.
While the transition into keto can be uncomfortable, the symptoms of the keto flu usually go away within a week of following the diet.
I see no reason to introduce a potentially dangerous product to help with this short transitional period.
If you are struggling with the “keto flu”, drink plenty of water, cut back on intense exercise, get lots of rest, eat enough fat, and consider adding more salt to your food for a few days.
The symptoms of fatigue should pass quickly as your body adjusts.
While I am not opposed to the keto diet short-term for weight loss or other potential health benefits, it is not sustainable long-term.
It may also increase blood cholesterol in some people.
If your goal is weight loss or improved energy, a diet full of fruits, vegetables, and lean protein is the healthiest and most sustainable without having to cut out all the foods you love.
At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.
- Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry:
- Ketogenic Diet for Obesity: Friend or Foe?:
- Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?:
- On the Metabolism of Exogenous Ketones in Humans:
- CDC: Sodium:
- Utility of Ketone Supplementation to Enhance Physical Performance: A Systematic Review:
- A Ketone Ester Drink Lowers Human Ghrelin and Appetite:
- Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments:
- Review: taurine: a "very essential" amino acid:
- Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men:
- The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists:
- Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis:
- Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content:
- 2015-2020 Dietary Guidelines:
- Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects:
- Effects of caffeine on human behavior: