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Active-PK Review: Pros, Cons, Effectiveness, and More

Written by Melissa Mitri, MS, RD

Published on December 29, 2020

Our Expert Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:3.0
  • Ingredient Safety:3.0
  • Value for the Price:2.0
  • Brand Transparency:3.0

Active-PK is a supplement intended to boost energy, promote clearer thinking, and combat abdominal fat. I feel this supplement is generally safe, however, its effectiveness is questionable at these lower doses.

Active-PK Review: Pros, Cons, Effectiveness, and More


  • Antioxidant and anti-inflammatory
  • 90-Day money-back guarantee
  • Ingredients have been researched


  • Questionable effectiveness of ingredients
  • High cost

What Is Active-PK?

Active-PK is a dietary supplement that claims to fight fatigue and reduce abdominal fat so you can enjoy a stronger, slimmer feeling body.

It does this, in theory, by activating a compound called AMPK, otherwise known as your body’s metabolic “master switch.”

AMPK is an enzyme heavily involved in energy production and metabolism.

In particular, it may help reduce the build-up of fat around the belly area.

This enzyme has been shown to decline as we age.

If Active-PK helps the body produce more of this enzyme, this hypothetically can result in more energy, fewer cravings, clearer thinking, and an overall slimmer waistline.

This supplement was developed by LCR Health, a nutraceutical company based in Los Angeles, California.

Dr. Rand Mcclain is the founder, a regenerative and sports medicine doctor.

As a health professional, I do appreciate that this product has been created by a doctor and the fact that several research studies are cited on the website.

Evaluation of Ingredients

Active-PK contains 3 core ingredients:

1. Gynostemma Pentaphyllum Leaf Extract

Gynostemma pentaphyllum is an herb sometimes referred to as “Southern Ginseng.” It may play a role in activating the enzyme AMPK.

This can activate many metabolic functions such as those involved in fat breakdown.

This herb may be involved in improving insulin sensitivity in those who have diabetes. It also may support weight loss by activating AMPK.

This helps promote the body’s ability to use fat for energy, rather than for storage.

There are a few recent studies that have shown that this herb may be effective for weight loss without any significant side effects.

2. Quercetin Dihydrate

Quercetin dihydrate is one of many health-promoting plant compounds called flavonoids.

Quercetin is found naturally in many fruits, vegetables, and red wine.

Because it is abundant in many foods, I would question the need for it in a supplement.

Some research has shown that quercetin has both antioxidant and anti-inflammatory properties.

However, the most effective dose without the risk of side effects is not yet known. If you have a well-balanced diet, I don’t feel a quercetin supplement would be necessary.

Additionally, flavonoids may be more effective when combined with other nutrients present in the food, not in an isolated supplement.

3. Berberine HCL

Berberine HCL is a compound found in several plants that has many potential health benefits.

It appears to also activate AMPK to better regulate metabolism.

In one small study, Berberine was shown to produce weight loss and improve insulin sensitivity.

However, most of the benefits were seen in doses of around 500mg three times per day, much higher than the 100mg present in Active-PK.

Verdict on Claimed Benefits

Here is our summary of the available support for the claimed benefits of Active-PK, based on the available studies:

  • Weight lossSome Support
  • Boost energySome Support
  • Clearer thinkingSome Support

Cost and Where to Buy

Active-PK is sold directly from LCR Health or on Amazon:

  • The cost when purchased directly from LCR is $89.95 for a one-month supply.
  • If you purchase from Amazon, the cost is only $47.95.
  • You can receive a discount if you purchase at least 3 months’ worth of product from the manufacturer.

This product is expensive. There is a more flexible, 90-day money-back guarantee if you purchase from LCR Health compared to only a 30-day guarantee from Amazon.

I would still recommend purchasing from Amazon, as it is a pretty significant cost-savings.

Comparison to Alternatives

There are a few differences between Active-PK and other metabolism boosters on the market.

First, Active-PK does not contain caffeine or any other stimulants.

For a supplement intended to increase energy, this provides a more natural source of energy from herbs.

It is also dairy-free and free of synthetic additives.

LCR Health states that this supplement is third-party tested in an independent lab. However, I could not find Active-PK listed on any reputable third-party sites.

The cost of this supplement is significantly more expensive than products with similar ingredients intended to boost energy, which range around $25–$35/month.

For example, there is the Super Smart AMPK Booster supplement that costs $42/month.

This product also contains Berberine in higher amounts which have shown to be more effective in the research.

Dosage, Side Effects, and Safety

The dosage recommendation is 2 capsules once per day with food or on an empty stomach.

Side effects of the 3 ingredients are possible. Gynostemma pentaphyllum is considered possibly safe when used for up to 4 months.

Side effects such as digestive issues and nausea have been reported.

Additionally, it has been linked to possible birth defects and so is not recommended during pregnancy or lactation.

Possible side effects of quercetin include headache, tingling of the arms and legs, and kidney damage in those who have kidney problems.

Potential side effects of Berberine include stomach pain, nausea, or diarrhea.

If you have diabetes and are already on blood sugar lowering medication, it is advised to speak with your doctor prior to starting Berberine HCL.

The Bottom Line

I feel this product is generally safe for consumption, with a low risk of side effects.

This is partially due to the fact that the dosages of each ingredient are significantly lower than what has been tested in research studies.

However, while that increases its safety profile, this could render it less effective.

As a registered dietitian, I would suggest speaking to your doctor first before starting anything new, in order to assess the benefits vs. risks of taking it.

As always, I would initially recommend establishing a healthy lifestyle routine through a combination of diet, exercise, and stress management to improve health, mental clarity, and longevity.

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