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Bio Complete 3 Review: A Promising Probiotic Blend for Gut Health

By Erika Thiede, MS, RDN, CSSD

Medically Reviewed by Natalie Olsen, MS, RDN, LD, ACSM-EP

Last Updated on August 13, 2022

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:3.8
  • Ingredient Safety:4.5
  • Customer Service:4.0
  • Value for the Price:4.5

Bio Complete 3 is a gut health supplement designed to promote digestive health, support weight loss, and improve energy. This high-quality formula includes a blend of probiotics, prebiotics, and postbiotics to support gut health.

Written by
Erika Thiede, MS, RDN, CSSD
Registered Dietitian Nutritionist, Integrative and Functional Nutritionist
Erika Thiede is a Registered Dietitian Nutritionist with 10 years of experience in the field of nutrition. While at USC, Erika worked alongside the head sports dietitian, allowing her to realize her true passion was in the field of nutrition and dietetics. Erika completed her master’s degree at Loma Linda University and became a registered dietitian in 2015.
Medically Reviewed by
Natalie Olsen, MS, RDN, LD, ACSM-EP
Registered Dietitian, Certified Exercise Physiologist
Natalie is a registered dietitian, functional medicine practitioner and certified exercise physiologist with over 15 years experience in the health and wellness industry and holds a Master's degree in Human Nutrition and Functional Medicine through a collaborative program provided by the University of Western States and the Institute of Functional Medicine.

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Bio Complete 3 Review: A Promising Probiotic Blend for Gut Health
Photo by WellnessVerge


  • Contains prebiotics, probiotics and postbiotics to improve gut health.
  • May deliver on claimed benefits.
  • Includes clinically studied ingredients.
  • Has 90-day money-back guarantee.


  • May be expensive to some.
  • Not clear on how many probiotic CFUs per serving.

One of the keys to solid and sustainable health lives in our gut.

Research shows that the intestines’ microbes interact significantly with our mind, heart, and overall wellness.

Healthy and balanced gut bacteria have been linked to decreased depression, anxiety, mood, immune conditions, and metabolic conditions such as type 2 diabetes and obesity. (1, 2, 3)

Ensuring optimal gut health is essential for anyone wanting to take steps towards improving their overall health.

That’s why some people turn to supplements to help support just that.

This article will review Bio Complete 3 — a gut health supplement — and help you understand how it works, its potential benefits, safety consideration, cost, and whether it’s the right choice.

What Is Bio Complete 3?

Bio Complete 3 is a gut health supplement founded by Dr. Gundry — a cardiac surgeon with over 30 years of experience.

The product supports gut health by providing a blend of probiotics, prebiotics, and postbiotics.

  • Probiotics: Essential bacteria in the digestive tract that are known to improve digestive health and support a healthy immune function. (4)
  • Prebiotics: Act as fuel for probiotics, helping the essential bacteria grow — often in the form of fiber.
  • Postbiotics: Produced by the fermentation process carried out by beneficial bacteria. (5)

As a result of the above-mentioned fermentation, short-chain fatty acids such as Butyrate are produced. (6)

Research shows that Butyrate — found in the form of Tributyrin in Bio Complete 3 — is the primary energy source for the cells that line the colon. (5)

With the inclusion of prebiotics, probiotics, and postbiotics, Bio Complete 3 offers a comprehensive product to support your gut’s integrity and total body wellness.

Does Bio Complete 3 Work? Evaluation of Claimed Benefits

Bio Complete 3 includes prebiotics, probiotics, and postbiotics to improve gut health and overall wellness.

When taken daily, Bio Complete 3 claims to:

  • Improve gut health
  • Support weight management
  • Increase energy levels
  • Decrease food cravings

The formula contains the probiotic Bacillus coagulans. However, the amount listed is 16 mg, which does not provide information on how many CFUs are available per serving.

This information would be helpful for better determining how much live bacteria you are ingesting. However, when combined with a healthy lifestyle and the combination of prebiotics and postbiotics, Bio Complete 3 may still offer benefits.

Below we will review each of the claimed benefits, their respective ingredients, and scientific research.

Improve Gut Health

Bio Complete 3 contains a probiotic, prebiotic, and postbiotic blend that may improve digestive health.

Probiotics are living microorganisms that are believed to produce health benefits when ingested.

The gut microbiota’s functions include digestion, vitamin production, and metabolism. Probiotics aid in these functions. (4)

Probiotic supplementation in healthy adults may improve the concentration of beneficial gut bacteria, leading to improved digestion, better bowel movements, and less gas and bloating. (7)

Research has found that the probiotic Bacillus coagulans — present in Bio Complete 3 — can withstand the stomach’s acidic environment to reach the intestine where it grows. (8)

Once B. coagulans is active in the small intestine, it has been shown to improve the groups of beneficial bacteria, resulting in better digestion, less abdominal pain, and less bloat. (8)

Research has found B. coagulans to protect the intestinal tract against pathogens, creating a healthier and more efficient gut. (8)

Bio Complete 3 also includes SunFiber — a prebiotic shown to play a positive role in digestive health and promotes better stool frequency and consistency. (9)

However, one small study confirmed 5 grams per day of SunFiber had positive effects. Bio Complete 3 contains much less at 200 mg per serving. (9)

Finally, postbiotics such as Butyrate have been recognized for their beneficial effects on intestinal health.

With anti-inflammatory properties, Butyrate enhances intestinal barrier function and immunity. (10)

With a healthy diet and lifestyle, Bio Complete 3 contains a combination of probiotics, prebiotics, and postbiotics that may benefit gut health.


Probiotics, prebiotics, and postbiotics are essential in ensuring a healthy digestive system. While eating a healthy diet is critical in ensuring a healthy gut, Bio Complete 3 may be a practical option for extra support to improve your gut health.

Support Weight Management

Bio Complete 3 includes a blend of ingredients that may improve weight loss and support weight management.

The probiotic in Bio Complete 3 is. B coagulans — research has shown B. coagulans to play a role in the digestion of carbohydrates and protein and may maximize the benefits of protein supplementation. (11)

Optimal protein intake and absorption are necessary for weight loss. (12)

Additionally, prebiotics — such as SunFiber — are critical in increasing the good bacteria in our gut. (13, 14)

Clinical studies have determined that microbial diversity has a preventive effect on long-term weight gain in healthy individuals. (4)

While Bio Complete 3’s SunFiber content is lower than most clinical studies, combined with a fiber-rich diet, it may provide benefits associated with weight loss.

Finally, Butyrate — present in Bio Complete 3 as Tributyrin — may play a promising role in improving fat metabolism and decreasing obesity-induced fat accumulation. (15)


The combination of the prebiotic, probiotic, and postbiotic present in Bio Complete 3 may be helpful in supporting weight management.

Related: Can Probiotics Help You Lose Weight?

Increase Energy Levels

Having a healthy gut is one important factor in improving energy levels. Bio Complete 3 is made with ingredients that support a healthy gut in a variety of ways.

Around 45% of the US population reports feeling fatigue. Recent studies have shown the health of the gut microbiome is correlated with this feeling. (16)

One study confirmed bacteria in the gut influence both mental and physical energy and fatigue. It was shown that certain bacteria influence inflammation — which contributes to fatigue — while other good bacteria influence feelings of energy. (16)

The ingredients in Bio Complete 3 may support optimal energy levels by improving the diversity of bacteria in the gut.

Research has found that more diverse bacteria may lead to better absorption and availability of nutrients, decreased inflammation, and increased energy production from food. (4)

The probiotic B. coagulans in Bio Complete 3 has been shown to aid in the digestion of carbohydrates and protein, allowing the body to utilize nutrients better. (11)

Supporting optimal gut health and optimal digestion of nutrients may lead to improved energy and quality of sleep. (17)


Healthy bacteria in the gut are correlated with improved energy. Bio Complete 3 may contribute to improving energy levels by increasing the diversity of good bacteria and enhancing the absorption of nutrients.

Decrease Food Cravings

Bio Complete 3 may reduce food cravings by supporting a healthy balance of gut bacteria with its prebiotic content.

Clinical research has shown that different microbes in our gut may have an effect on the foods we are craving. (18)

Prebiotic supplementation — such as SunFiber present in Bio Complete 3 — may improve the good bacteria in the gut. (13, 14)

Studies have shown that having a positive balance of gut bacteria may lead to less cravings and food addictions. (19)


If taken alongside a healthy lifestyle, Bio Complete 3 may decrease food cravings by supporting overall gut health and a balance of good bacteria.

The Evidence Score

Here is our score, based on scientific evidence, of how likely Bio Complete 3 will be effective for its claimed benefits:

Improve digestion4.25/5
Support weight management4.25/5
Increase energy levels3.25/5
Decrease food cravings3.25/5

Supplement Facts

Bio Complete 3’s nutrition information per serving (4 capsules) includes:

  • Calories: 10
  • Total Fat: 1 gram
  • Saturated: 1 gram
  • CoreBiome (Standardized to 30% Tributyrin): 1000 mg
  • SunFiber: 200 mg
  • ProDURA (Baccillus Coagulans): 16 mg

Other ingredients include Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Sunflower Oil, Fatty Acids Esterfied with Glycerol, Magnesium Stearate, Silica, Maltodextrin.

How to Take Bio Complete 3

The recommended dosing for Bio Complete 3 is four capsules a day, taken morning or night.

For optimal benefits, it is recommended to take this product daily.

Bio Complete 3 capsules
Photo by WellnessVerge

Safety and Side Effects

Probiotics such as Bio Complete 3 are generally safe for healthy adults.

However, caution should be used with taking probiotics if:

  • You have a weakened immune system, a critical illness, or have recently had surgery. This is due to a possible risk of infection in certain people. (20, 21)
  • You suffer from GI conditions. You must review with your physician before beginning supplementation, as some probiotics may worsen your condition.
  • You are pregnant or nursing. Bio Complete 3 is not intended for pregnant or nursing individuals without doctor supervision.

Bio Complete 3 is gluten-free, vegetarian, and free of added sugars. It has also been third-party tested to ensure purity and potency.

While side effects are not widely reported, some people may deal with mild side effects from probiotic supplements in general — such as diarrhea and bloat.

Cost and Where to Buy

Bio Complete 3 is not sold in stores and must be purchased directly from the online store at gundrymd.com.

Each bottle provides a 30-day supply.

Purchase options include:

  • One Bottle: $69.95, or $49.95 with a subscription
  • Three Bottles: $188.85, or $134.85 with a subscription
  • Six Bottles: $353.70, or $254.85 with a subscription

While the product is pricier than other probiotic supplements, it can help you save money if purchased in bulk.

Bio Complete 3 offers a 90-day money-back guarantee — if you are not fully satisfied with your purchase, you will be issued a refund, minus the cost of shipping.

How Bio Complete 3 Compares to Other Brands

Bio Complete 3 is unique with its prebiotic, probiotic, and postbiotic combination.

Comparable products include Seed Daily Synbiotic and Ritual Synbiotic+.

Seed Daily Synbiotic

Seed is comparable to Bio Complete 3, with a blend of 24 clinically-studied probiotic strains and a prebiotic.

Seed has been clinically shown to support:

  • Digestive health
  • Skin health
  • Nutrient synthesis
  • Heart health

Seed Daily Synbiotic is a highly tested supplement that undergoes third-party testing to determine the availability of the probiotics through the digestive tract.

Compared to Bio Complete 3, Seed has undergone more thorough testing and includes a broader range of probiotics. A variety of probiotics may be helpful because different probiotics have different functions and health benefits.

Seed costs $49.99 for a month’s supply, including shipping and a free travel vial.


If you are looking for a comprehensive probiotic supplement, Seed Daily Synbiotic is a great choice and comes at a lower price point than Bio Complete 3.

Buy Seed Daily Synbiotic

Ritual Synbiotic+

Ritual Synbiotic+ provides a 3-in-1 blend of probiotics, prebiotics, and postbiotics to support gut health.

The probiotic blend includes Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis in 11 billion CFUs.

The blend may relieve mild and occasional digestive discomforts such as bloating, gas, and diarrhea. (22)

The prebiotic — PreforPro — is designed to target undesirable gut bacteria and support healthy gut bacteria growth.

Finally, Ritual contains Tributyrin — a form of Butyrate to act as a postbiotic.

Ritual is the most comparable to Bio Complete 3, with third-party testing and clinical trials to support its claims.

Ritual Synbiotic+ is $50 for a 30-day supply.


Ritual Synbiotic+ is a comprehensive option to support gut health and comes at a lower price point than Bio Complete 3.

TRY Ritual Synbiotic+

Comparison Chart

Bio Complete 3 Seed Daily Synbiotic Ritual Synbiotic+
Regular Price $69.95 for 1-month supply $49.99 for 1-month supply $50 for 1-month supply
Discounted or Subscription Price $49.95 for 1-month supply $49.99 for 1-month supply No subscription available
Shipping $4.95 or free on orders over $50 Free shipping Free shipping for most locations
Returns 90-day money back 30-day money back 30-day money back
Key Ingredients

Bifidobacterium coagulans



Bifidobacterium longum Bifidobacterium breve

Organic rice fiber

Lactobacillus rhamnosus Bifidobacterium animalis


PreforPro Probiotic blend

Third-Party Tested
Clinical Studies
Form Pill Pill Pill

The Bottom Line

Bio Complete 3 may be an excellent option for your daily regimen if you find yourself struggling to eat a balanced diet and need support managing a healthy gut.

This supplement is ideal for individuals looking for a comprehensive gut health formula with probiotics, prebiotics, and postbiotic ingredients.

To see optimal results, it is best to take the product consistently.

When using the subscription service, the cost of the product is similar to alternative products. For peace of mind, if you do not see results, you can return it for a refund with their 90-day risk-free trial.

Additionally, it is best to combine Bio Complete 3 with a well-balanced diet and healthy lifestyle.

An excellent first step is ensuring a diet that includes fiber-rich foods such as whole grains, fruits, and vegetables.

Furthermore, a healthy intake of probiotic-containing foods such as kefir, Greek yogurt, and fermented vegetables helps maintain optimal gut health.

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At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.

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