Mind Lab Pro Review: Benefits, Drawbacks, and Is It Worth It?
Mind Lab Pro is a nootropic that is claimed to help six major pathways of mental performance. This supplement stands out from the rest by supplying quality ingredients in a comprehensive formula that is backed by research.
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Mind Lab Pro is a reported Universal Nootropic designed to support short-term cognitive function and long-term brain health.
Nootropics are brain-enhancing drugs or supplements that are reported to help improve brain health and cognition.
Mind Lab Pro contains 11 active ingredients that are claimed to target six pathways of mental performance.
These include brain energy, brain chemistry, brain circulation, brain protection, brain waves, and brain regeneration.
The serving size of Mind Lab Pro is 2 capsules per day, taken in the early morning or early afternoon.
Individuals may start feeling effects from Mind Lab Pro after taking it consistently for two weeks, but it is recommended to take it for at least 30 days to see full effects.
Mind Lab Pro contains 11 active ingredients that come from either standardized or patented proprietary forms. These ingredients are:
- Vitamin B6, 2,5 mg
- Vitamin B9, 100 mcg
- Vitamin B12, 7.5 mcg
- L-theanine, 100 mg
- Citicoline, 250 mg
- Bacopa monnieri, 150 mg
- Organic lion’s mane mushroom, 500 mg
- Phosphatidylserine, 100 mg
- N-acetyl L-tyrosine, 175 mg
- Rhodiola rosea, 50 mg
- Maritime pine bark extract, 75 mg
Vitamin B6 (as NutriGenesis)
Vitamin B6 (pyridoxine) is a water-soluble vitamin commonly found in meat and fish, fortified cereals, legumes, bananas, and starchy vegetables.
Vitamin B6 is needed for the synthesis of neurotransmitters. It also protects neurons and allows for faster communication between nerve cells.
It protects the brain by regulating the activity of glutamate, which is important for reducing excitotoxicity.
Excitotoxicity is described as the toxic actions of certain neurotransmitters that can lead to decreases in brain function and cell death if not controlled.
Deficiency of vitamin B6 is associated with impaired brain function, seizures, depression, nerve damage, and premature aging of the brain.
Despite the known effects of vitamin B6 deficiency, a 2020 review of recent literature did not find studies demonstrating vitamin B6 as an effective supplement to prevent cognitive decline in individuals with cognitive impairment.
Vitamin B6 is essential for the many important functions in keeping the brain healthy. Though current research does not support vitamin B6 for preventing cognitive decline, preventing vitamin deficiency is important for brain health.
Vitamin B9 (as NutriGenesis)
Vitamin B9, also known as folate, is a water-soluble vitamin present in a wide variety of food sources.
This vitamin plays an important role in the synthesis and breakdown of neurotransmitters, DNA synthesis, and regulation of nerve cells.
Symptoms of folate deficiency are similar to those seen in vitamin B12 deficiency and include cognitive impairment, depression, dementia, nerve damage, and spinal cord problems.
In a 2016 meta-analysis, folic acid supplementation with vitamin B6 or B12 was not beneficial in preventing further cognitive decline in older adults with Alzheimer’s disease or dementia.
Long-term supplementation is needed to reduce symptoms of folate deficiency due to folate having to pass through the blood-brain barrier.
Folate is necessary to preserve brain health. Folic acid supplementation may not prevent cognitive decline, but it can reduce brain-related symptoms of folate deficiency in the body.
Vitamin B12 (as NutriGenesis)
Vitamin B12 is a water-soluble vitamin found in meat, seafood, milk products, fortified cereals, and fortified nutritional yeast.
Vitamin B12 contributes to nerve health by helping protect nerves from damage.
The deficiency of vitamin B12 can result in pernicious anemia, which can have severe effects on the brain, including impaired cognitive function, impaired neurotransmitter production, damage to nerves, and spinal cord injury.
Vitamin B12 greatly affects proper nerve function. Current research suggests that vitamin B12 supplementation can help with improving nerve-related symptoms caused by vitamin B12 deficiency.
L-Theanine (as Suntheanine)
L-theanine is an amino acid found in tea and mushrooms. It is structurally similar to glutamate, the major neurotransmitter in the body.
L-theanine can increase alpha-wave activity in the brain and relaxation without causing drowsiness.
In a 2016 study, healthy adults aged 18–40 years drinking a nutrient drink containing 200 mg of L-theanine and small doses of phosphatidylserine and alpha-GPC reported a decreased subjective stress response and cortisol response to a multitasking cognitive stressor compared to a placebo.
Resting alpha waves were significantly greater in individuals with anxiety who had the beverage.
A 2019 randomized trial found that L-theanine supplementation of 200 mg for four weeks improved verbal fluency and executive function compared to a placebo in healthy adults.
A small 2018 study found that a beverage containing 200 mg of L-theanine or a combination of L-theanine and caffeine improved attention during a color stimulus task compared to a placebo.
L-theanine increases alpha brain waves, can improve cognitive function, and decrease stress in amounts of 200 mg. Mind Lab Pro does not contain a clinically active dose in its normal serving size, but a full dose of L-theanine can be achieved if taking a double dose.
Citicoline (as Cognizin)
Citicoline is the generic name of a compound called CDP-choline, which happens to be a precursor to phosphatidylcholine.
Phosphatidylcholine is a phospholipid and precursor to the neurotransmitter acetylcholine.
This neurotransmitter is associated with improved cognitive function, working memory, and attention.
Citicoline supplementation can be effective for brain health by increasing the synthesis of phospholipids, helping nerve cell regeneration, and may help restore activity after brain injury.
A 2020 review found that supplementation with citicoline can improve cognitive functioning in healthy adults and improve prognosis after stroke.
Cognizin, the standardized extract of citicoline, was found in a 2021 clinical trial to improve memory performance amongst older adults with age-associated memory impairment after having 500 mg daily doses of Cognizin for 12 weeks.
Citicoline supports brain health in several ways. Studies find that supplementation with citicoline can improve cognitive function and protect against neurodegenerative conditions.
Bacopa monnieri Aerial Parts (as Full-Spectrum Extract, 24% Bacosides with 9 Bioactives)
Bacopa monnieri is an herb used in Ayurvedic and Traditional Chinese Medicine to enhance cognitive function.
The major active component of Bacopa monnieri includes a type of phytochemicals called bacosides, which have neuroprotective and antioxidant activities.
A 2019 review found that supplementation with Bacopa monierri improves cognitive performance, memory, and stress.
Bacopa monierri was found in one 2017 study to have a synergistic effect with other nootropics in improving cognitive status, stress, and depression in elderly adults.
Bacopa monnieri has neuroprotective activities and can improve cognitive function and performance. These effects can be increased in combination with other nootropics.
Organic Lion’s Mane Mushroom (Full-Spectrum)
Lion’s mane mushroom is an edible mushroom often found on hardwood trees.
This may assist with neural development the alleviation of brain-related symptoms from certain conditions.
Animal studies find that extracts of lion’s mane mushrooms may have anti-anxiety and anti-depressant-like activities.
Lion’s mane mushroom fruit extracts may also improve nerve growth factor and protect against dementia.
Lion’s mane mushroom has active compounds that could protect against nerve damage and inflammation and support nerve growth. However, most of the research available on lion’s mane for cognitive health is animal and cell studies, so results are difficult to translate to humans.
Phosphatidylserine (as Sharp-PS Green from Sunflower Lecithin)
Phosphatidylserine is an abundant phospholipid in the brain that is needed for the activation of several signaling pathways to support neuronal growth, survival, and communication.
A 2010 study found that older adults aged 60 or older with subjective memory complaints taking 100 mg or 300 mg of a soy-based phosphatidylserine supplement for 6 months had improvements in memory and delayed verbal recall compared to a placebo.
Phosphatidylserine supports the survival of neurons, nerve growth, and nerve development. Supplementation appears to be effective in improving memory, decreasing stress, and improving attention.
L-tyrosine is an amino acid found in foods including dairy, meat and seafood, avocadoes, nuts and seeds, and bananas.
It is a precursor to dopamine and norepinephrine, which are both neurotransmitters.
L-tyrosine supplementation can reduce neurotransmitter depletion, a process in which increased brain activity will decrease concentrations of dopamine and norepinephrine.
Depleted dopamine and norepinephrine can have a negative impact on behavioral performance and working memory.
Supplementation with L-tyrosine can improve cognitive performance during short-time stress or cognitively demanding tasks if there is neurotransmitter depletion.
L-tyrosine is a precursor to dopamine and norepinephrine, and supplementation can help cognitive performance in individuals experiencing neurotransmitter depletion.
Rhodiola rosea Root (3% Rosavins, 1% Salidrosides)
Rhodiola rosea, also known as rosenroot, is a perennial flowering plant that acts as an adaptogen.
R. rosea supports brain health through several mechanisms, including antioxidant activity, improving mood, and inhibiting the breakdown of certain neurotransmitters.
R. rosea is also seen in research to be effective in Alzheimer’s disease treatment.
R. rosea can help reduce some of the effects of stress and protect brain health.
Maritime Pine Bark Extract (95% Proanthocyanidins)
Maritime pine bark extract, or pycnogenol, comes from trees that are native to coastal Mediterranean countries.
Pycnogenol extracts contain several phenolic compounds, including catechins, flavonoids, and phenolic acids.
Maritime pine bark extract supports brain health by reducing oxidative stress, suppressing inflammation in the brain, increasing antioxidants, and helping after traumatic brain injury.
Nitrites from the metabolism of pine bark extract can also stimulate nitric oxide production, which can improve cerebral blood flow.
Pycnogenol supplementation may improve cognitive function.
In a 2019 review, pycnogenol supplementation between 100 to 150 mg per day may improve attention, memory, executive functioning, mood, cognitive performance, and oxidative stress markers.
Maritime bark extract appears to be an effective supplement with antioxidant activity to improve cognitive function. Mind Lab Pro does not contain this ingredient in clinical doses in its standard serving, but levels can be reached if taking a double dose.
Below is our summary of the available evidence for the claimed benefits of Mind Lab Pro based on the available research:
|Brain energy||Gold Star Evidence|
|Brain chemistry||Strong Evidence|
|Brain circulation||Moderate Evidence|
|Brain regeneration||Gold Star Evidence|
|Brain protection||Gold Star Evidence|
|Brain waves||Gold Star Evidence|
There is strong evidence to support several claims of this product.
The B-vitamins support brain energy, phosphatidylserine helps promote brain regeneration, and several ingredients help protect the brain from oxidative stress.
Several ingredients have human trials on the benefits for memory, mood, and attention, but lion’s mane is lacking human trials.
Finally, the evidence on brain circulation is limited to animal and cell studies only.
There are some side effects to note with Mind Lab Pro.
Bacopa monnieri may cause gastrointestinal effects, including increased bowel movements, abdominal cramps, and nausea.
Phosphatidylserine side effects may include belching, acid reflux, high blood pressure, and uneasiness.
Pycnogenol may increase heart rate in some people.
This supplement is only meant for adults ages 18 years or older and should not be taken if pregnant or nursing.
Speak with your doctor before taking Mind Lab Pro to see if this supplement is safe for you to use.
The standard dosing of Mind Lab Pro is 2 capsules a day and should be taken in the morning or early afternoon.
You can take up to 4 capsules in a 24-hour period in times of intense cognitive demands, but you should not exceed this amount.
Mind Lab Pro acknowledges that in the standard 2-capsule serving size, not all of the nootropic ingredients are in clinically supported doses.
However, if taking a 4-capsule dose, all 11 ingredients of this supplement will be in clinical doses.
If you are taking Mind Lab Pro, it is recommended that you cycle, or take a break from this supplement occasionally.
The makers of Mind Lab Pro recommend either cycling Mind Lab Pro for a “4 weeks on, 1 week off” cycle or a weekly “5 days on, 2 days off” cycle.
Mind Lab Pro is 100% vegan-friendly, free of major allergens, gluten-free, formulated with non-GMO ingredients, and is free of caffeine, synthetic additives, artificial colors, and preservatives.
The only additive used in Mind Lab Pro is NuFlow Rice Concentrate to avoid caking of ingredients.
Opti-Nutra, the manufacturers of Mind Lab Pro, claims to have higher quality standards beyond current Good Manufacturing Practices (cGMP).
Their manufacturing facilities meet certification standards for a number of entities and are NSF International GMP compliant and US Pharmacopeia (USP) certified.
Mind Lab Pro is only available to purchase through their website. A one-month supply of this supplement is $69 per box.
You can also purchase a 2-month supply or 3-month supply from the website. If you choose the 3-month supply, you can get a free box, which lowers the price per box to $51.75.
Mind Lab Pro has a straightforward return policy. They allow you to use the product for 30-days (up to 1 bottle, assuming that you are taking the standard dose) and give 60 days from delivery for a full product refund.
Mind Lab Pro has a unique and comprehensive formula of nootropics to support various functions of brain health.
I think it is also unique in that the manufacturers of Mind Lab Pro are genuine about their commitment to quality ingredients and testing through meeting guidelines for a number of independent testing bodies.
Mind Lab Pro is formulated with standardized and patented ingredients to confirm quality across batches of their product and ensure that their ingredients have sufficient bioactivity.
Compared to other nootropic tablets or capsules, you only need to take between 2–4 capsules to get your desired results.
Some nootropics on the market have serving sizes between 4 to 7 capsules per day, which can be burdensome to take.
Other nootropics are also cheaper than this product but often contain fewer ingredients and have varying quality of ingredients.
Mind Lab Pro has an advantage over other nootropics by including well-researched ingredients, high quality, and serving sizes that are not a burden to take.
It may be pricier than other nootropics, but it appears to be worth trying.
Mind Lab Pro is a nootropic supplement that is thorough in its approach to supporting brain health.
It has a unique formulation of nootropic ingredients and is made of quality ingredients to get you a consistent product.
For this reason, the price of Mind Lab Pro is understandable when you consider the number of ingredients and quality testing that goes into making this product.
My main disappointment with this supplement is that a standard dose of Mind Lab Pro does not supply clinical concentrations of ingredients and may require you to take more pills.
Because of this, the outcomes you may desire from this supplement may not be as prominent as expected.
Still, I think that it has the edge over other multi-ingredient nootropics and could be worth trying.
Before you start Mind Lab Pro or any other supplement, speak with your doctor to see if a nootropic supplement can safely fit into your routine.
If you have other questions about cognitive health, your doctor can address any concerns you may have about your health.
If you’re unable to take nootropics or want to support your brain health regardless of what supplements you take, there are some things you can do daily.
Fruits, vegetables, and whole grains provide antioxidants that reduce inflammation and protect against free radicals damage in your body.
Eating protein foods can help you get the B vitamins you need for neurotransmitter synthesis and brain health.
At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.
- B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin:
- Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases:
- Vitamin B-Can it prevent cognitive decline? A systematic review and meta-analysis:
- Emerging roles for folate and related B-vitamins in brain health across the lifecycle:
- The neurology of folic acid deficiency:
- Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases:
- B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review:
- Vitamin B12 Deficiency: Recognition and Management:
- L-theanine, a natural constituent in tea, and its effect on mental state:
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial:
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial:
- l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study:
- Cholinergic modulation of cognitive processing: insights drawn from computational models:
- Citicoline - a neuroprotector with proven effects on glaucomatous disease:
- Application of Citicoline in Neurological Disorders: A Systematic Review:
- Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial:
- Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I:
- Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies:
- Short-Term Impact of a Combined Nutraceutical on Cognitive Function, Perceived Stress and Depression in Young Elderly with Cognitive Impairment: A Pilot, Double-Blind, Randomized Clinical Trial:
- Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds:
- Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation:
- Therapeutic Potential of Hericium erinaceus for Depressive Disorder:
- Phosphatidylserine in the brain: metabolism and function:
- Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints:
- Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress:
- The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study:
- Behavioral and cognitive effects of tyrosine intake in healthy human adults:
- Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans:
- Rosenroot ( Rhodiola): Potential Applications in Aging-related Diseases:
- Rhodiola rosea for physical and mental fatigue: a systematic review:
- Rhodiola rosea L. as a putative botanical antidepressant:
- Stress management and the role of Rhodiola rosea: a review:
- Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy:
- Neuroprotective effect of Pycnogenol® following traumatic brain injury:
- Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol):
- Assessing the Efficacy and Mechanisms of Pycnogenol ® on Cognitive Aging From In Vitro Animal and Human Studies:
- Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial:
- Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men:
- Pycnogenol supplementation as an adjunct treatment for antidepressant-induced sexual dysfunction: