SeroVital Review (Original and Advanced): Is It Safe and Effective? A Detailed Look
SeroVital is an anti-aging supplement and metabolism booster, which appears to be promoted primarily for women over age 45. There is limited evidence to support the ingredients in this product for its intended purpose.
SeroVital is an anti-aging and metabolism booster intended to delay the aging process by increasing levels of HGH, a growth hormone that tends to decline as we age. HGH helps our cells to regenerate.
The thought is that since HGH levels decrease as we age, if they can be increased to more “youthful” levels, this may slow the aging process.
This product contains a “renewal complex” of 6 different ingredients claimed to do this.
The ingredients are meant to increase HGH levels naturally without containing any hormones.
The intended goal is to increase energy, reduce body fat, decrease wrinkles, improve mental and physical capacity, and support a deeper, more restorative sleep.
The product appears to be marketed primarily to women, but they state it has also worked for men ages 18–70 in the manufacturer’s clinical trial.
There are two types of SeroVital products – Original and Advanced. SeroVital Original contains 6 main ingredients.
SeroVital Advanced contains these same 6 ingredients plus an additional 2 pills with multiple vitamins, minerals, and herbal extracts.
As a registered dietitian, I am skeptical of this product. I would not recommend this product given its overall lack of evidence for its effectiveness and safety, as well as its steep price.
Also, I do not see an about page on who created the product and their expertise.
There are claims on the website that their product is proven to have raised HGH levels significantly in their clinical trial.
However, the references to research studies shared on the website are not complete and are outdated.
There is no actual proof that raising HGH levels actually leads to any of the reported benefits, based on the one clinical trial that was conducted.
Overall, there was only one small randomized clinical trial that tested the effectiveness of SeroVital directly. This study showed that it increased HGH levels by over 600%.
However, HGH levels were only increased for a few hours. It is, therefore, unknown if these increased levels would be sustained long enough to produce any health benefits.
Additionally, the study results did not measure if any metabolic changes were actually seen from increasing HGH levels.
SeroVital Original contains 6 main ingredients – most of which are not typical for an anti-aging product.
SeroVital Advanced contains an additional 2 pills, which are stated to be metabolism-boosters by reducing appetite, cravings, and supporting weight loss.
Below is my review of the 6 core ingredients, which are part of the SeroVital Proprietary Blend (2.9 g per serving, individual dosages are not listed):
1. L-lysine Hydrochloride
L-lysine is an amino acid – a protein-building block. It is required for the formation of collagen, a protein that helps to protect and support the skin.
While there is some research into l-lysine and its wound healing properties, the research is limited on its role in delaying the aging process.
2. L-arginine Hydrochloride
L-arginine is another amino acid that builds protein in the body. There is some research on the role of l-arginine in reducing blood pressure, chest pain, and erectile dysfunction.
However, it may come with side effects and can interact with prescription medications.
Oxoproline is an amino acid byproduct that is not well studied. It is added to some skin and hair products but is reported to be expensive.
Because of the lack of research behind it, I would not suggest taking it in supplement form.
4. N-acetyl L-cysteine
N-acetyl cysteine (NAC) is an amino acid with many functions, including making the antioxidant glutathione.
Glutathione may help reduce cellular damage as we age and promote longevity.
L-glutamine is an amino acid that is involved in supporting the immune and digestive systems.
There is some research into the benefits of taking l-glutamine when the body is deprived of it.
This can occur when the body is under stress and is immunocompromised, such as in the case of an infection. Although if a person is not immunocompromised, it is unclear if L-glutamine further boosts the immune system.
Some research has explored if glutamine can increase muscle mass and performance. However, the results have not yet demonstrated this.
6. Schizonepeta Powder
Schizonepeta is a Chinese herbal remedy thought to have anti-inflammatory and antioxidant properties.
One animal study showed that schizonepeta might reduce inflammation in mice, but the dose is higher than what is likely present in this supplement blend.
It's also unclear if these effects would also be seen in humans.
While cases are rare, certain Chinese herbals such as schizonepeta may cause liver injury, especially in those that already have liver problems.
Below is our summary of the available evidence for the claimed benefits of SeroVital based on the available research:
- Reduced fine lines and wrinklesLimited Evidence
- Decreased body fatLimited Evidence
- Increased energyLimited Evidence
- Deeper, more restorative sleepLimited Evidence
- Immune system supportLimited Evidence
I am concerned that raising HGH levels as much as this product claims may pose health risks.
Reported side effects of excess HGH levels include leg and arm swelling, increased cholesterol levels, mood changes, an enlarged heart, insulin resistance, high blood sugar, and liver damage.
Furthermore, the common side effects of taking the amino acids present include nausea, vomiting, stomach pain, low blood pressure, and heartburn.
Also, schizonepeta powder can cause liver problems.
The recommended dose is 4 capsules per day at least 2 hours after dinner. If taking the Advanced formula, the morning blend capsules should be taken daily with breakfast.
Before starting this supplement, always speak to your doctor to weigh out the risks versus benefits, especially if you have a history of liver disease.
SeroVital is sold directly on the manufacturer’s website or Amazon from third-party sellers.
The cost is $119 for a 30-day supply or $238 for a 90-day supply. You can also get a discount for signing up for the company’s subscribe-and-save program.
If you choose to purchase this product, I’d recommend purchasing directly from the SeroVital website to assure the money-back guarantee.
There are many anti-aging products on the market. Many of these products contain completely different ingredients than the ingredients present in SeroVital.
Typical anti-aging ingredients that have been more extensively researched include curcumin, CoQ10, EGCG, and collagen.
Many other anti-aging supplements are also significantly less expensive than SeroVital, and typically run around $15–$25 for a 30-day supply.
Even so, I would still not suggest any type of anti-aging supplement before first practicing healthy daily lifestyle habits and checking with your doctor.
Most of the ingredients in SeroVital Original and SeroVital Advanced do not have enough evidence for me to support their use.
Additionally, it is an immediate red flag to me that it is not clear who even created this product and what their level of expertise is.
If you are concerned about aging, I would instead recommend establishing daily lifestyle habits that support a healthy weight, metabolism, and promote longevity.
Lastly, always consult with your healthcare provider before starting a new supplement.
I have seen firsthand how effective creating healthy lifestyle habits can be for my clients. These habits can produce the same results as this expensive product claims to do.
Habits such as eating a nutritious diet, engaging in regular exercise, and reducing stress will create the biggest benefits for your health. This is what I’d recommend to my clients.
If you want to remain as healthy as possible as you age, I suggest working with your doctor and consulting with a registered dietitian to learn how to improve your diet and lifestyle habits.
At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.
- Lysine post-translational modifications of collagen:
- S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans:
- Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine:
- Enhancement of lysine acetylation accelerates wound repair:
- Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation:
- Traditional Chinese Medicine Induced Liver Injury:
- Off-label use of hormones as an antiaging strategy: a review: