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The 5 Best Anti-Aging Supplements of 2021, According to Dietitians

Written by Sharon Lehman, RDN

Reviewed by Anthony Dugarte, MD 

Published on July 30, 2021

Looking to look younger than your chronological years? An anti-aging supplement may help you achieve that youthful glow.

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The 5 Best Anti-Aging Supplements of 2021, According to Dietitians

You’ve heard the expression “age is but a number.” It’s certainly true that you’re only as old, or young, as you feel.

The human life expectancy is longer than ever before, so it’s important to understand what ages the body and what you can do to keep your body healthy and in good working order for as long as possible.

Aging is natural and unavoidable. While there are no magic pills to keep you looking and feeling forever young, supplements with ingredients that target aging at the source—the cellular level—may help you slow the hands of time and enjoy many healthy years to come.

Summary of Our Picks

What We Look for in an Anti-Aging Supplement

Many vitamins, minerals, and antioxidants offer anti-aging benefits.

You’ll also find herbs, plant compounds, collagen, fish oil, and more in supplements that promise a more youthful appearance, enhanced energy, cellular rejuvenation, and aging in reverse.

While it’s not possible to entirely erase physical signs of aging, like wrinkles, sagging skin, and age spots, it is possible to slow the aging process and preserve health by providing the body with substances that naturally decline as we age.

Before those outward signs and symptoms of age appear, aging is always occurring at the cellular level.

Every part of your body is made of cells, which are in a constant state of turnover. Every time a cell regenerates, it has to copy and replicate the DNA it contains.

DNA encounters damage through oxidative stress. Substances called free radicals and reactive oxygen species (ROS) create lesions in DNA.

These substances also shorten telomeres, which are a protective part of each chromosome.

As you age, the body becomes less efficient at repairing this damage for a number of reasons. Genetics and chronic inflammation play a large role in the aging process.

Some factors that accelerate cellular damage include ultraviolet light, environmental pollutants, poor nutrition, stress, drugs, and alcohol. Some of these factors are within your control, while others are not.

If your body can’t keep up with repairing the amount of cellular damage it incurs, impaired DNA gets copied into new cells, which is believed to be one of the root causes of age-related decline, chronic disease, and shorter lifespans.

Cellular damage also leads to senescence, which is the end of a cell’s life cycle when cells completely stop dividing.

Some substances can help cells defend against oxidative stress and inflammation, two processes that lead to damage and premature wear and tear on our cells.

We looked for anti-aging supplements that are designed to decrease inflammation and provide antioxidant support.

I’ve put together this list of supplements that contain some of the best ingredients to help your body minimize oxidative stress.

This list is not all-inclusive but highlights some of the more researched substances that scientists have found to enhance cellular health, longevity, and physical signs of aging.

How to Choose the Best Anti-Aging Supplement for You

Here are some things to consider as you choose the best anti-aging supplement to add to your routine:

Claimed Benefits: Paying attention to what a product claims it can do for your health can help you understand its formulation if you're unfamiliar with the ingredients. If you’re looking for an anti-aging supplement that boosts energy or reduces fine lines and wrinkles, look for these benefits on the product packaging.

Form and Dosage: Consider the form and dosage of the supplement to make sure it’s realistic for you to take long-term. Anti-aging supplements work best when they’re taken regularly. Because cellular aging is ongoing, any benefits you experience may cease if you stop taking the supplements after a few weeks or months. Make sure the supplement you choose is easy to use.

Price: The supplement’s price is also a key consideration since you’ll likely take anti-aging supplements long-term. Consider the ongoing cost per month to make sure it fits within your budget.

Allergens: Supplements can contain common allergens, like dairy, fish, or soy. Check the ingredient label if you have dietary restrictions.

Third-Party Certification: Most supplements claim to be third-party tested for ingredient safety, purity, and potency. However, without an official seal on the product, you have to trust the manufacturer on this. If ingredient quality is non-negotiable for you, look for a seal on the product label. Common ones include NSF International and Consumer Labs.

Medical Conditions: You should always check in with your primary healthcare provider before starting a new supplement. Some age-related concerns may stem from an underlying medical condition that needs to be managed by a doctor.

Based on all of the above, I pulled together the following product suggestions broken down by three of the biggest aspects of aging: cellular health, longevity, and skin health.

Best Anti-aging Supplements for Cellular Health

NAD+, resveratrol, and CoQ10 are ingredients to look for to support cellular health.

NAD+ is a coenzyme involved in numerous cellular functions, including the production of energy.

A group of proteins, called sirtuins, keep cells healthy and require NAD+ to function. Unfortunately, levels of NAD+ naturally decrease with age.

Supplementing with nicotinamide riboside, which is one of five precursors to NAD+, increases levels of NAD+, supports mitochondrial function, and can prolong the life of cells.

Resveratrol, known as the red wine compound, is found in the skin of grapes and berries. It displays powerful antioxidant, anti-inflammatory, and antitumor properties in clinical trials. Resveratrol also enhances sirtuin function.

CoQ10 (coenzyme Q) is also naturally found in the body. It has antioxidant properties that protect cell membranes from oxidative stress and supports mitochondrial function.

Providing cells with these substances can help them continue to function, repair the damage, and replicate.

ResveraCel by Thorne

Best for Cellular Health
Rating Breakdown
  • Support for Claims:4.0
  • Ingredient Safety:4.0
  • Value for the Price:3.0
  • Brand Transparency:4.0

Overall Rating:



  • Supports NAD+ levels
  • Contains well-studied antioxidants
  • 60-day satisfaction guarantee


  • Expensive
  • No third-party testing seal

ResveraCel is a supplement made by Thorne Research available in capsule form. It contains nicotinamide riboside, resveratrol, quercetin, and betaine.

Quercetin is an antioxidant found in some foods, like grapes, berries, citrus fruit, and tea, with many health benefits, including decreasing cellular senescence in human stem cells.

Betaine is an amino acid found in plant and animal foods that has anti-inflammatory properties and may also play a role in improving body composition by decreasing fat mass.

Nicotinamide riboside has been studied for safety in lab animals. No serious side effects have been noted even at high intakes on lab animals, but some mild side effects, including flushing of the skin, leg cramping, and nausea, have been reported in human studies.

Resveratrol, quercetin, and betaine are considered safe for most healthy people.

Price: $48 for a 30-day supply.

The Bottom Line: ResveraCel is more expensive than other Niagen supplements, but the addition of resveratrol, quercetin, and betaine may result in greater anti-aging benefits.

Doctor’s Best Ubiquinol

Best for Cellular Health
Rating Breakdown
  • Support for Claims:4.0
  • Ingredient Safety:4.0
  • Value for the Price:5.0
  • Brand Transparency:4.0

Overall Rating:



  • Preferred form of CoQ10 for enhanced bioavailability
  • Accessible at major retailers
  • Affordable


  • Return policy varies depending on the retailer that you buy from

Each dose of Doctor’s Best Ubiquinol contains 100 milligrams of coenzyme Q10 as ubiquinol, which is the active form of CoQ10.

CoQ10 supplements containing ubiquinol increase levels of CoQ10 more than supplements containing an equal amount of ubiquinone, the oxidized form of CoQ10.

A 2019 study found CoQ10 dissolved in fat in soft gel form is more bioavailable than hard capsules or powdered form.

Doctor’s Best Ubiquinol soft gels contain extra virgin olive oil and MCTs for enhanced absorption.

Ubiquinol and CoQ10 supplements are generally well tolerated. However, some people may experience mild digestive upset, which may be countered by taking this supplement with food.

Price: About $25 for a 2-month supply.

The Bottom Line: Doctor’s Best Ubiquinol is formulated for enhanced absorption and bioavailability and can help support CoQ10 levels.

Best Anti-Aging Supplements for Longevity

EGCG and turmeric are ingredients to look for to support overall health and longevity.

Both ingredients display powerful antioxidant and anti-inflammatory properties and are dietary staples in Blue Zones around the globe.

EGCG is a catechin compound found in green tea. Although more research in humans is needed, it’s shown promising benefits in the test tube and animal studies, including longer lifespan and skin anti-aging benefits.

Turmeric is the golden spice found in curry powder. The active ingredient in turmeric is curcumin, but it’s present in very low amounts and not very well absorbed.

Turmeric supplements contain concentrated doses of curcumin designed for bioavailability.

The anti-inflammatory mechanisms of EGCG and curcumin are also believed to lessen the risk of developing chronic diseases, like heart disease and type 2 diabetes, that can shorten the lifespan.

Pure Encapsulations Green Tea Extract

Best for Longevity
Rating Breakdown
  • Support for Claims:4.0
  • Ingredient Safety:4.0
  • Value for the Price:4.0
  • Brand Transparency:4.0

Overall Rating:



  • Dose meets safety suggestions
  • Affordable
  • Allergen-free


  • No third-party testing

Pure Encapsulations Green Tea Extract contains 100 milligrams of green tea extract standardized to contain a minimum of 70% EGCG.

The product does not contain any caffeine, which is one benefit to supplementing with green tea extract versus consuming tea.

This supplement can be taken by those who are sensitive to caffeine and stimulant-related side effects. The capsules are vegetarian and do not contain any common allergens.

One cup of brewed green tea is estimated to contain 50–100 milligrams of catechins, so the amount of EGCG in this product is equivalent to drinking 1 to 2 cups of tea.

A 2018 systematic review suggests 338 milligrams of EGCG per day is a safe amount to avoid liver toxicity. Unfortunately, many other green tea extract supplements contain doses of EGCG that are double to triple this amount.

Price: $25 for a 2-month supply.

The Bottom Line: Pure Encapsulations Green Tea Extract is a good choice if you’re sensitive to caffeine and is within the safety suggestions for EGCG dosage.

Swanson Curcumin Complex

Best for Longevity
Rating Breakdown
  • Support for Claims:5.0
  • Ingredient Safety:5.0
  • Value for the Price:4.0
  • Brand Transparency:5.0

Overall Rating:



  • Formulated for enhanced absorption
  • Affordable
  • Allergen-free
  • Third-party tested


  • Return policy varies depending on the retailer that you buy from

The curcumin complex in this supplement is standardized to contain 95% curcuminoinds and delivers 700 milligrams of curcumin per dose.

It also contains BioPerine, also known as black pepper extract, which has been clinically proven to increase the absorption rate of curcumin up to 2000%.

Swanson is a trusted supplement brand and subjects all its products to third-party testing for optimal quality.

Each dose is two capsules, and the formula is free from common allergens.

Curcumin and black pepper extract are generally well tolerated. However, a few mild side effects related to curcumin supplements have been documented, including nausea, diarrhea, headache, and rash.

Price: $19 for a 2-month supply.

The Bottom Line: Swanson Curcumin Complex is formulated for optimal absorption and is third-party approved for quality.

Best Anti-Aging Supplement for Skin

No list of anti-aging supplements is complete without addressing outward signs of aging, which tend to be consumers’ greatest concern.

Outward signs of aging can include wrinkles, dry skin, and loss of skin elasticity that results in sagging.

Collagen, vitamin C, and hyaluronic acid are the best ingredients to prevent signs of skin aging.

These ingredients are generally safe for all healthy adults to take, and adverse reactions are rare.

Collagen is a structural protein found in the skin. A 2019 review concluded collagen supplementation is effective at increasing skin elasticity and hydration, which may result in the reduction of the appearance of wrinkles.

Hyaluronic acid binds with water and can also enhance skin hydration to reduce the appearance of dry, dull skin.

Vitamin C is one of the best-known antioxidants that can counteract cellular damage. It also plays a role in the body’s production of collagen.

Collagen is sourced from animals, so it’s not a good choice for anyone following a vegetarian or vegan lifestyle.

Some collagen products contain common allergens, like fish or eggs. Be sure to check the ingredient label if you have food allergies or sensitivities.

Vital Proteins Collagen Peptides

Best for Skin
Rating Breakdown
  • Support for Claims:3.0
  • Ingredient Safety:4.0
  • Value for the Price:4.0
  • Brand Transparency:4.0

Overall Rating:



  • Collagen sourced from responsibly-raised cattle
  • Powdered form is versatile and easy to use
  • Minimal ingredient list
  • Free from common allergens


  • Lacks third-party testing seal
  • Contains only two types of collagen
  • Return policy varies depending on the retailer that you buy from

Vital Proteins has an extensive collection of collagen supplements, including powders, ready-to-drink beverages, and gummies.

The collagen is sourced from either grass-fed cattle or wild-caught fish and is hydrolyzed (i.e., broken down) for better absorption.

I recommend their original powdered Collagen Peptides product, which contains all the ingredients mentioned above.

It dissolves in cold or hot liquids, so you can use it in smoothies, coffee, broth, or other recipes.

The recommended dosage is two scoops of collagen per day, which provides 18 grams of protein, 20 grams of hydrolyzed collagen, 90 milligrams of vitamin C (100% of the Daily Value), and 80 milligrams of hyaluronic acid.

Collagen supplements are considered safe with no adverse effects to note. Some people report mild digestive upset when taking collagen, but research hasn’t documented this finding.

Price: $42 for a 20-ounce tub.

The Bottom Line: Vital Proteins Collagen Peptides is easy to incorporate into your daily routine and may support skin health. It costs a bit more than other collagen peptide powders, but it provides more grams of collagen per serving. Purchasing the larger, 20-ounce tub is more cost-effective.

Frequently Asked Questions About Anti-Aging Supplements

  • At what age should I start taking anti-aging supplements?

    Most people don’t think about anti-aging supplements until they notice a few wrinkles in the mirror or feel more achy or forgetful than they used to. In reality, supplementing with antioxidants, like resveratrol, curcumin, and CoQ10, can start at any point in adulthood. No anti-aging supplement can make you age in reverse. Still, the sooner you start to minimize inflammation and stress that leads to aging, the better.

  • What is the best supplement for younger-looking skin?

    No supplement guarantees younger skin. Eating a diet rich in vitamins, minerals, and antioxidants helps promote youthful skin. In particular, vitamins C, D, E, and K benefit skin health. If you’re worried about nutritional gaps, ask your healthcare professional if you should be taking a multivitamin. It’s also important to hydrate the skin by drinking plenty of water and protecting the skin from oxidative damage that occurs from exposure to ultraviolet light. Preventative measures include wearing sunscreen and protective clothing.

  • I cook with turmeric. Do I need to supplement with it, too?

    Unfortunately, our bodies aren’t efficient at absorbing curcumin from turmeric. So you’d need to eat large quantities to get enough curcumin to match doses associated with health and anti-aging benefits. Most curcumin supplements contain concentrated doses of curcumin plus other ingredients, like black pepper extract, to help enhance absorption.

  • What other ingredients offer anti-aging benefits?

    Omega-3 fatty acids possess anti-inflammatory properties and are one of the nutrients credited with enhancing longevity in Blue Zones found around the globe. The best sources of omega-3’s are fatty fish, like salmon, or fish oil supplements. You can also find omega-3’s in walnuts, flax seeds, and chia seeds. Garlic, as well as some spices like cinnamon and ginger, have powerful antioxidant and anti-inflammatory properties.

  • Besides supplements, what else can I do to support longevity?

    Choose nutrient-dense foods like fruits, vegetables, beans, and whole grains to ensure you’re getting a variety of vitamins, minerals, and antioxidants. Avoid hydrogenated oils, trans fats, excessive alcohol, and sugary foods. Stay well-hydrated.

    Prioritize getting enough sleep, managing stress levels, and engaging in regular physical activity. Doing activities you enjoy for your mind and body is crucial for happiness, mental wellness, and overall health and longevity.

The Bottom Line

There are many supplements and nutrients that can provide anti-aging benefits.

Before choosing an anti-aging supplement, consider your primary goal and look for a product that claims to address that goal.

You should also speak with your primary healthcare provider to help you choose the right supplement that’s the best and safest for you.

Although aging cannot be prevented, some supplements may give your cells an edge to keep functioning optimally for longer.

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