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Multi-GI 5 Review: An Analysis of Its Effectiveness and Safety

By Markita Lewis, MS, RD

Medically Reviewed by Anthony Dugarte, MD

Last Updated on February 10, 2022

Dietitian Rating:

3.7

About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:4.8
  • Ingredient Safety:3.0
  • Value for the Price:3.0
  • Brand Transparency:4.0

Multi-GI 5 is a dietary supplement from Unify Health Labs designed to improve digestive health, combat food cravings, and boost feelings of energy. This high-quality probiotic may improve digestive health, but it is quite expensive compared to similar products.

Written by
Markita Lewis, MS, RD
Registered Dietitian Nutritionist
Markita Lewis is a registered dietitian with over 5 years of experience in the field of nutrition and health. Prior to her professional career, Markita completed a combined masters and dietetic internship program at the University of Georgia. She obtained her undergraduate degree at Louisiana State University in Nutrition and Foods Sciences, concentrating in dietetics with a minor in Psychology.
Medically Reviewed by
Anthony Dugarte, MD
Medical Reviewer
Anthony Dugarte, M.D., C.S.C.S. is a health and wellness writer and medical content reviewer. In addition to dedicating the last 7 years to medical research, Dr. Dugarte also has more than a decade of experience in strength and conditioning, nutrition, and rehabilitative exercise, as well as authoring and reviewing health and wellness-related content.

WellnessVerge is reader-supported. When you make a purchase through links on this page, we may earn a commission. Learn More

Multi-GI 5 Review: An Analysis of Its Effectiveness and Safety
Photo by WellnessVerge

Pros

  • Contains both prebiotics and probiotics
  • Ingredients are evidence-based for supporting gut health
  • Product has 90-day money-back guarantee

Cons

  • The product is expensive
  • Some ingredients are not in sufficient doses for claims made

What Is Multi-GI 5?

Multi-GI 5 is a comprehensive gut health supplement that combines a unique “GI Health” blend, prebiotics, and probiotics.

Overall, it is designed to help with soothing the digestive tract and supporting its integrity, as well as help with other GI issues, including “leaky gut.”

The proprietary GI Health Blend is claimed to help with nutrient bioavailability, reduce GI discomfort, and support the lining of your gut.

The included prebiotic blend supports nutrient absorption and aids digestion.

The probiotic strains in this supplement are reported to help with digestion optimization, weight management, and gas and bloating reduction.

Altogether, this supplement has 16 main ingredients to support gut health, which in turn, the creators at Unify Health Labs believe will help with overall body health.

To take Multi-GI 5, mix 1 scoop of powder (6.4 g) with water or tea. For best results, you should take this supplement daily.

Multi-GI 5 is an easy-dissolve powder that creates a strawberry-lemonade flavored drink that can be taken at any time of the day.

About Unify Health Labs

When you think about supplements to promote gut health, it’s not too often that you also think about the music industry. However, these two things have more in common than you would think.

Unify Health Labs was founded by Randy Jackson, who is largely known for his eclectic music career. Some of his roles include singer, record producer, bassist for the rock band Journey, and judge on American Idol.

Randy Jackson was inspired to start Unify Health Labs after a trip to the ER, where he learned of his diagnosis of Type 2 diabetes.

After a long and arduous journey to improve his physical health, Randy Jackson found a passion for creating a simpler way to help others meet their health goals.

He founded Unify Health Labs, which consists of a diverse team of health experts and has advisors, including Dr. Melina Jampolis, a board-certified physician nutrition specialist, to guide the process of creating their supplements.

Evaluation of Ingredients

Multi-GI 5 Supplement Facts
Photo by WellnessVerge

Multi-GI 5 contains three proprietary blends – GI Health Blend (333 mg), Prebiotic Blend (4 g), and Probiotic Blend (37.64 mg) to support gut health.

Here’s what the research has to say about the ingredients in this supplement and how they support gut health.

GI Health Blend, 333 mg

Fermented L-Glutamine, 200 mg

L-glutamine is an amino acid that is important in metabolism and immune function.

A randomized trial found that supplementation with 5 g of L-glutamine three times a day for 8 weeks was effective in reducing intestinal permeability and IBS symptoms in patients who developed IBS-D following enteric infection. (1)

Magnesium Beta-Hydroxybutyrate (BHB), 70 mg

Magnesium BHB is a ketone body that is produced by the body in its fasting state, which, when taken exogenously, may be beneficial in enhancing healthspan in humans. (2)

One study investigating the impact of BHB infusion on cognitive performance in individuals with type-2 diabetes found that the ketone solution improved working memory but did not affect any other cognitive measure. (3)

Magnesium BHB also acts as an energy substrate during ketosis, meaning that it can be used in the body as a source of ATP (an energy molecule) by different body tissues. (2)

Deglycyrrhizinated Licorice Root Extract, 50 mg

Licorice root extract is used for its anti-inflammatory and anti-ulcer effects and may have additional benefits due to its flavonoids. (4)

Many of the studies on licorice for gastric ulcer treatment are from the 60s and 70s, so it’s difficult to determine if they were using the best research methods in their studies.

The current body of research on deglycyrrhizinated licorice root would benefit from having updated studies.

BioPerine Piper Nigrum Extract, 10 mg

This extract from the black pepper plant has anti-diarrheal properties and can aid with digestion and absorption of nutrients from foods. (5)

In a 2019 study analyzing the effects of black pepper and other spices, black pepper was found to act as a prebiotic and positively impact the growth of certain types of bacteria in the gut. (6)

Berberine Hydrochloride, 3 mg

Berberine hydrochloride is a plant-based compound that can be found in several plants.

In an animal study, rats with induced ulcerative colitis had decreases in inflammatory cytokines after supplementation with berberine hydrochloride. (7)

More human clinical trials need to be done on the effectiveness of this compound on gut health.

Zinc (from Zinc Carnosine Complex), 1 mg

Zinc carnosine has a role in immune function and wound healing through its anti-inflammatory and antioxidant functions.

A review of studies finds that zinc carnosine helps with gastric ulcer healing, prevents gut permeability, and helps with other gut mucosal repairs. (8)

Summary

The ingredients in the GI Health Blend may help reduce gut inflammation and gastric ulcers, support the strength of the gut wall, and reduce diarrhea symptoms. Magnesium BHB can be used by the body for energy production.

Prebiotic Blend, 4 g

Fructooligosaccharides (Inulin) from Chicory Root, 4 g

Inulin is a fermentable fiber found in many plants but often comes from chicory root when used in supplements.

A 2019 review of the benefits of inulin finds that inulin improves gut microbiota, stimulates immune function, reduces the risk of irritable bowel diseases, lowers the risk of colorectal cancer, decreases constipation, and increases mineral absorption. (9)

While fructooligosaccharides like inulin can help increase satiety, the current research suggests that you need an intake of over 16 g/day of this dietary fiber for at least 12–16 weeks to make a difference in appetite and energy. (10)

Studies find that taking less than 10 g of fructooligosaccharides generally does not affect appetite.

Summary

Inulin is a prebiotic fiber that is beneficial for gut health and immune function. While inulin can support appetite control, the amount of inulin in Multi-GI 5 is not enough to affect appetite.

Close-up of Multi-GI 5 powdered supplement
Photo by WellnessVerge

Probiotic Blend, 37.64 g

Lactobacillus gasseri, 100 billion cfu/g, 7.13 mg

L. gasseri is a probiotic isolated from human breast milk.

One study found that 12 weeks of L. gasseri supplementation in overweight individuals resulted in increased weight loss, reduced waist circumference, and reduced fat accumulation. (11)

Another small trial found that L. gasseri supplementation in adults with irritable bowel symptoms had improvements in the severity of symptoms after four weeks compared to a placebo. (12)

Bacillus coagulans (as ProDura), 150 billion cfu/g, 7.26 mg

A review of clinical trials finds that B. coagulans has a number of benefits for gastrointestinal health. (13)

This probiotic is found to help restore microbiota balance, decrease inflammation, reduce clinical symptoms in IBS and other gastrointestinal diseases, and improve diarrhea caused by various factors.

Lactobacillus rhamnosus, 350 billion cfu/g, 7.13 mg

L. rhamnosus is an effective probiotic in aiding the integrity of the intestinal walls and can effectively prevent and treat several digestive ailments. (14)

A meta-analysis of studies finds that L. rhamnosus effectively treats diarrhea in children and adults, but the quality of studies is moderate to low. (15)

Lactobacillus casei, 300 billion cfu/g, 7.13 mg

This bacterium is found naturally within the human microbiome and fermented dairy products.

L. casei shows promise in disease prevention, weight loss and obesity management, brain function, immunity support, and more. (16)

The L. casei Shirota strain has been found in multiple studies to reduce constipation. (17)

Lactobacillus plantarum, 400 billion cfu/g, 3 mg

Lpb. plantarum is a probiotic often found in fermented and functional foods such as kimchi and pickled products.

A review of studies finds that Lpb. plantarum is effective for inhibiting pathogenic bacteria, reducing inflammation, immune health, and reducing symptoms of gastrointestinal infections. (18)

Animal studies suggest this bacteria may also be important in brain development and function through the gut-brain axis. (19)

Summary

The strains of bacteria found in Multi-GI 5 are shown to be effective for supporting gut health, reducing symptoms of gastrointestinal conditions, and supporting a healthy gut microbiota. Some included strains have the potential to support weight loss.

Verdict on Claimed Benefits

Below is our summary of the available evidence for the claimed benefits of Multi-GI 5 based on the available research:

Healthy digestionGold Star Evidence
Balanced gut floraGold Star Evidence
Healthy GI liningGold Star Evidence
Improved weight managementStrong Evidence
Increased energyGold Star Evidence

Many of the ingredients included in Multi-GI 5 have good research to support their benefits for gut health.

A few clinical studies show that some of the included probiotics may support weight loss, but the research is limited.

The included ketones in Multi-GI 5 can increase ketone-based energy production in the body.

Dosing, Safety, and Side Effects

To take Multi-GI 5, mix 1 scoop of powder (6.4 g) with water or tea. Multi-GI 5 can be taken at any time of the day.

Probiotics are generally considered safe in healthy adults, but there may be a risk for individuals who are immune-compromised or have existing gastrointestinal issues. (20)

When starting a new probiotic, you may experience temporary increases in bloating or gas as the balance of bacteria shifts.

Some ingredients in Multi-GI 5 may cause side effects if taken at high doses, including inulin and licorice root.

Inulin, and similar fibers, may cause abdominal discomfort, gas, and diarrhea at high doses. (21)

Side effects from high doses of licorice root include high blood pressure, hypokalemia (low potassium), and fluid retention. (22)

Among the inactive ingredients, Multi-GI 5 contains some natural sweeteners, including erythritol, stevia, and monk fruit extract.

The research is inconclusive on the potential effects of natural and nonnutritive sweeteners on the gastrointestinal tract. (23)

Ask your doctor before taking any dietary supplements to prevent possible negative health effects.

Related: How and When to Take Probiotic Supplements

One scoop of Multi-GI 5 mixed in a glass of water
Multi-GI 5 powder mixes easily with water and has a very sweet lemonade taste. Photo by WellnessVerge

Cost and Where to Buy

Multi-GI 5 can be purchased directly from the Unify Health Labs website. 

  • 1-month supply: $69.95
  • 3-month supply: $188.85 ($21 savings)
  • 6-month supply: $353.70 ($66 savings)

Small discounts are available if purchasing Multi-GI 5 in bulk.

Unity Health Labs offers a 90-day money-back guarantee on their website if you are unsatisfied with your purchase and use of Multi-GI 5.

This product is also available on Amazon at a lower price, but buyers should take caution. While the product is shipped from Amazon, it is sold by a third party, making it difficult to guarantee its quality.

How Multi-GI 5 Compares to Alternatives

Unify Health Labs claims that Multi-GI 5 is unique from other digestive health supplements due to its particular blend of 16 ingredients.

Multi-GI 5 has the advantage of having a GI support blend for gut health and energy production in addition to their prebiotic and probiotic mix.

I think this adds value for anyone looking for additional anti-inflammatory support and benefits from their probiotic of choice.

Seed Daily Synbiotic is a good alternative to Multi-GI 5.

This brand has greater transparency about the exact concentration of probiotics in its formula, has 24 strains that target not only gut health but whole-body health, and has a prebiotic that is low FODMAP-friendly.

Multi-GI 5 notes the cfu/g of their probiotics on the website, but the product only contains milligrams of each probiotic in their proprietary blend (so without some extra math, you don’t know how much you’re receiving).

If you’re looking for a more cost-effective probiotic for gut health, Envive Daily Probiotic is a good option.

It has a clinical study showing that it can improve function GI symptoms within 30 days while also being significantly cheaper than Multi-GI 5. (24)

Though Multi-GI 5 has well-studied ingredients, there are no clinical trials examining the efficacy of the Multi-GI 5 formula.

The cost of Multi-GI 5 is higher than many other probiotic/prebiotic blends available. A quick search online offers alternatives largely ranging between $25–$55 for a month’s supply.

Related: How to Choose the Best Probiotic Supplement

The Bottom Line

The Multi-GI 5 supplement appears to be formulated based on credible science and may be beneficial for gut and body health based on its ingredients.

However, this supplement is quite pricey, and you may be able to find other prebiotic/probiotic blends at a better price.

Multi-GI 5 is for people looking for a comprehensive gut health supplement that has probiotics, prebiotics, and gut-supporting ingredients all in one.

In combination with a healthy diet and exercise, this supplement could potentially be a good complement for weight loss.

This supplement may not be for people looking for a budget probiotic/synbiotic, or people who have serious gastrointestinal health conditions who may need particular probiotics and prebiotics.

Before starting a new supplement, speak with your doctor first to see if it is appropriate and safe for you.

Next Steps

Using synbiotics like Multi-GI 5 can be a great way to kickstart your journey to having better gut health.

In addition, simple lifestyle changes can help maximize the benefits of your supplement.

First, support the growth of healthy bacteria by having prebiotics and high-fiber foods. On average, people need 30 grams of fiber per day.

To help you reach this goal, eat high-fiber foods like fruits, vegetables, beans and lentils, nuts and seeds, and whole grains.

If you’re eating more fiber-containing foods, be sure to increase your water intake to prevent constipation.

Second, incorporate foods that naturally have probiotics in them. Great examples of probiotic foods include kefir, miso, sauerkraut, yogurt, and pickles.

Lifestyle factors that also support a healthy gut include getting enough sleep at night for a healthy circadian rhythm, reducing stress (to regulate hormones and digestion), and getting regular exercise.

Try to limit alcohol intake and excessive use of sugar alternatives to optimize your gut health.

If you have more complex digestive concerns and needs, speak with a health professional like a registered dietitian or doctor specializing in GI health to assist with an individualized approach to your health needs.

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At WellnessVerge, we only use primary references for our articles, including peer reviewed medical journals or well-respected academic institutions.

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    https://pubmed.ncbi.nlm.nih.gov/30108163/
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  19. Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis:
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