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Equelle Review: A Promising Solution from a Trusted Brand

By Erika Thiede, MS, RDN, CSSD

Published on July 4, 2023

Dietitian Rating:


About This Rating
The average rating of this product is calculated based on the evaluation of the following factors:
  • Support for Claims:5.0
  • Ingredient Safety:4.0
  • Value for the Price:4.0
  • Customer Service:4.5

Equelle is a non-hormonal menopause supplement that has been clinically shown to offer relief from common symptoms. It is a promising natural option for women who can’t (or don’t want to) undergo HRT. Here’s what you should know before buying.

Written by
Erika Thiede, MS, RDN, CSSD
Registered Dietitian Nutritionist, Integrative and Functional Nutritionist
Erika Thiede is a Registered Dietitian Nutritionist with 10 years of experience in the field of nutrition. While at USC, Erika worked alongside the head sports dietitian, allowing her to realize her true passion was in the field of nutrition and dietetics. Erika completed her master’s degree at Loma Linda University and became a registered dietitian in 2015.
Equelle Review: A Promising Solution from a Trusted Brand
Photo credit: Equelle

Key Insights (TL;DR)

  • Equelle is a non-hormonal natural supplement with a single active ingredient, S-equol. It is derived from soy and mimics estrogen in your body to help decrease menopause symptoms.
  • Equelle has been clinically shown to relieve common symptoms of menopause, including hot flashes, mood swings, and vaginal discomfort, and improve sleep quality.
  • In clinical studies, Equelle provided some relief in as little as one month, with optimal results in 2–3 months.
  • On the brand’s website, consumer reviews are overwhelmingly positive. Many stated it was “life-saving” and helped with hot flashes and night sweats, often completely eliminating or significantly reducing them. Many patients also report that it helped with sleep and mood swings.
  • As with any menopause supplement, the product will not work for everyone. A small percentage of reviewers did not experience relief. Others experienced relief from some menopause symptoms but not all, while some reported that Equelle provided initial relief, but the symptoms returned over time.
  • Equelle is considered generally safe. In clinical studies, no safety issues were reported. However, some reviewers reported side effects (more on that in the safety section).

What Equelle Gets Right

  • It uses S-equal, an ingredient clinically validated to treat common symptoms of menopause.
  • It offers a non-hormonal alternative to women who can’t (or don’t want to) undergo hormone replacement therapy.
  • The product is hormone-free, gluten-free, dairy-free, and vegetarian.
  • The company offers a 90-day money-back guarantee, reducing the financial risk of trying the product.
  • Many consumers praised the helpfulness of customer service and also stated that this product was recommended to them by their physicians.
  • The company has a transparent website with helpful, consumer-centered information about the product.

Important Considerations

  • If you are allergic to soy, you should not use Equelle.
  • More expensive than some alternatives — extra costs could add up over time.
  • Not third-party tested for ingredient purity.
  • More extended studies would help understand long-term safety.
  • You will need to take the product consistently for at least 2–3 months before experiencing relief.
  • Some consumers report being charged after canceling the subscription. Although the issue was resolved by customer service, it still created a nuisance.

Equelle at a Glance

Menopause is a natural decline in women's reproductive hormones.

Menopausal transition affects each woman differently, but common symptoms include stubborn weight loss, fatigue, mood shifts, and hot flashes. While menopause is a normal part of life, it does not mean you need to suffer through the symptoms. (1)

Equelle is a menopause relief supplement produced by NatureMade, a reputable vitamin and supplement brand.

Equelle is the only menopause supplement made with S-equol, a plant-based, soy-derived ingredient that naturally mimics estrogen in the body.

Research has found that some women naturally produce S-equol in the gut after consuming soy-rich food. As a result, women with a high intake of soy food products experience milder symptoms of menopause. (2, 3)

However, clinical trials have documented that the body cannot produce enough S-equol to alleviate menopause symptoms from diet alone. (4)

S-equol has a similar molecular structure to estrogen. However, while estrogen replacement therapies bind to alpha and beta receptors, often leading to breast and uterine cancer risk, S-equol primarily binds to estrogen beta receptors, mimicking estrogen's effects in the body without the harmful side effects of estrogen. (5)

To use Equelle, you will need to take two capsules per day, 1 in the morning and 1 in the evening, both preferably with meals.

Overall, Equelle is a promising product worth considering if you are at any stage of menopause and experiencing symptoms, don’t want to or can’t undergo HRT, and are not allergic to soy.

Research Behind S-Equol, Equelle’s Main Ingredient

Equelle’s active ingredient, S-equol, is a plant-based compound derived from soy that has been proven safe and effective in clinical trials. The studies we reviewed showed that taking 10 mg of S-equol daily for 12 weeks improved menopause symptoms. That is the same daily dose as Equelle. Here is a breakdown of the benefits experienced in the clinical trials:

Reduction in Hot Flashes

Daily intake of Equelle may decrease the occurrence and severity of hot flashes in menopausal women. Specifically, in one study of 77 women receiving 10 mg of S-equol a day for 12 weeks, women experienced a significant decrease in menopausal symptoms, including a reduced frequency of hot flashes. (4)

Important Note: While 10 mg S-equol daily was shown to reduce the frequency of hot flashes for those experiencing eight or fewer daily, this product may not be the best fit if you are experiencing more daily hot flashes than that.

Improved Sleep

Poor sleep is often associated with menopause symptoms too. While Equelle does not increase lowering estrogen levels, its hormone-mimicking effects may improve sleep quality and serotonin levels. (6)

Specifically, clinical studies have found that supplementation of 10 mg of S-equol for 12 weeks improved night sweats and sleeping disturbances for over 90% of women. (7)

Improved Mood

With a lower estrogen production, women may experience poorer moods, including depression and anxiety. In a clinical study, women supplemented with S-equol for 12 weeks showed a significant decrease in depression and anxiety symptoms. (8)

Muscle and Joint Pain Relieve

In addition to reducing hot flashes, studies show that taking 10 grams daily of S-equol may help relieve muscle and joint pain in postmenopausal women. (9)

Is Equelle Safe to Take?

According to clinical research, S-equol, the active ingredient in Equelle, is safe and has no significant side effects. However, it is derived from soy, so people with soy allergies should not use it.

Some individuals have reported mild side effects from Equelle, such as bloating, rash, constipation, diarrhea, and gas. These side effects typically subside after a few days. If you have a sensitive stomach, it may be helpful to take Equelle with meals.

Taking Equelle with other supplements and over-the-counter or prescription medications should be safe. However, speaking with your physician before starting any new supplement, including Equelle, is always best.

Price & Buying Options

Equelle is only available for purchase on the main company website at the following prices:

  • One-Time Purchase: $50 per bottle
  • With Subscription: $40 per bottle (renews every four weeks)

The company provides free shipping and a 90-day money-back guarantee.

Try Equelle

How Equelle Compares to Alternatives

Menopause symptoms could last for a long time and could severely impact your quality of life. Many natural supplements on the market offer relief, but each comes with its own benefits and drawbacks.

When looking for an effective menopause supplement, it is important to consider the following:

  • Which menopause symptoms does the supplement address?
  • How does the supplement produce relief for menopause symptoms (aka its mechanism of action)?
  • Is there evidence for safety (preferably long-term) and effectiveness?
  • How long will it take to see initial relief?
  • What would be the ongoing cost of using the product?

Here’s a summary of how Equelle compares to well-known brands:






Relief of menopausal hot flashes, night sweats, mood swings, and vaginal symptoms

Relief of common menopause symptoms

Relief of common menopause symptoms, including weight gain

Relief of menopausal hot flashes and night sweats

Active Ingredients


Rhapontic Rhubarb Root Extract

Vitamin E, Ammonium Succinate, Calcium Disuccinate, Monosodium L-Glutamate, Glycine, Magnesium Disuccinate, Zinc Difumarate

Pollen + Pistil Extract PI-82, Pollen Extract GC-FEM

Mechanism of Action

Mimics the effects and actions of estrogen

Promotes beneficial estrogen-like activities

Regulates hormone production

It’s non-hormonal, but the mechanism is unclear; it may regulate serotonin levels

Hormone and Drug Free?










Scientific Evidence

Smaller, well-designed studies have shown that Equelle helped reduce hot flashes, night sweats, vaginal symptoms, and mood swings

Large, well-designed studies have shown that Estroven helped significantly reduce common menopause symptoms

Smaller, well-designed studies have shown that Amberen helped significantly reduce common menopause symptoms

Small, open-label studies have shown that Relizen reduces hot flashes and night sweats associated with menopause

Clinical Studies for Long-Term Safety

Studies (up to 12 weeks) have shown Equelle to be generally safe, longer studies are needed

Studies (up to two years) have shown Estroven to be generally safe for long-term use

Studies (up to 90 days) have shown Amberen to be generally safe, longer studies are needed

Studies (up to 90 days) have shown Relizen to be generally safe; longer studies are needed

How Long to Take to See Relief

Studies have shown initial relief in 2–3 months

Studies have shown initial relief in 4 weeks

Studies have shown initial relief in 30 days

Studies have shown initial relief by month 3

Form and Daily Dosage

2 tablets

1 caplet

2 capsules

2 tablets

Regular Price

$50 (30 servings)

$19.99 (28 servings)

$29.99 (30 servings)

$57 (30 servings)

Cost Per Serving





Estimated Annual Cost






Subscriptions can lower the cost by 20%

Subscriptions can lower the cost by 10%

Subscriptions can lower the cost by 10%

Subscriptions can lower the cost by 35%

Return Policy

90 days

60 days

60 days

30 days


Buy on Equelle Buy on Estroven Buy on Amazon Buy on Bonafide

How Do I Choose?

All of the above products could be a potential solution for women looking for hormone-free, natural relief from menopause symptoms. They all have varying degrees of clinical support for safety and effectiveness, contain unique combinations of ingredients, and all work in different ways. They all come from reputable brands and have a lot of positive consumer reviews.

Here are some tips on choosing the best one for you

  • Equelle is a great choice if you are not allergic to soy and are specifically looking to address hot flashes, night sweats, sleep quality, vaginal symptoms, and mood swings using a natural ingredient that mimics estrogen in your body.
  • If you have other symptoms that you need to address, Estroven or Amberen may be a better option, as they address a wider range of menopausal symptoms. (Note: Amberen is not plant-based.)
  • If you are looking for a more budget-friendly solution and something free of soy, Estroven would be the best option. It is half the cost of Equelle and works similarly by promoting estrogen-like activities.
  • If Equelle did not work for you, or you want to avoid hormone-mimicking ingredients, and hot flashes and night sweats are your main concerns, Relizen is worth considering as it has a different mechanism of action.

Tip: It is best to use any menopause supplement alongside a healthy lifestyle that includes consuming less caffeine, exercising, practicing stress management and relaxation techniques, and following an anti-inflammatory diet.

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At WellnessVerge, we only use reputable sources, including peer-reviewed medical journals and well-respected academic institutions.

  1. What Is Menopause? | National Institute on Aging:
  2. Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones - PubMed:
  3. Equol improves menopausal symptoms in Japanese women - PubMed:
  4. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women - PubMed:
  5. Estrogen Receptors Alpha (ERα) and Beta (ERβ): Subtype-Selective Ligands and Clinical Potential - PMC:
  6. Evaluation and Management of Sleep Disturbance During the Menopause Transition - PMC:
  7. Sampling Trial Showed S-equol Supplementation Helped Relieve Menopausal Symptoms (P06-111-19) - PMC:
  8. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women - PubMed:
  9. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency - PubMed: